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Fluoride-induced vascular endothelial injury and the protective mechanism of blueberry anthocyanins
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DOI：10.1016/j.fct.2025.115665.png)
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Abstract
En 中文
Long-term fluoride exposure poses significant risks to the cardiovascular system, with vascular endothelial damage being the critical initiating factor in fluoride induced CVDs. Fluoride's oxidative stress mediated toxicity disrupted endothelial function, highlighting the urgent need for protective strategies. Acy, known for its antioxidant properties, offered potential cardiovascular protection against fluoride induced damage. Previous studies by our group had identified the p53/miR-200c-3p pathway as a key molecular mechanism in fluoride-triggered endothelial injury.
Keywords:
fluoride
cardiovascular disease
vascular endothelial damage
oxidative stress
p53/miR-200c-3p pathway
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