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Gene regulation through exon junction complex modularity
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DOI：10.1038/s41594-025-01724-0.png)
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Abstract
En 中文
The exon junction complex (EJC) begins to assemble on the spliceosome, which deposits EJCs upstream of most exon–exon junctions during pre-messenger RNA (mRNA) splicing. EJCs acquire additional alternative modules that define heterogeneous EJCs during pre-mRNA processing to mRNA in the nucleus and after mRNA export into the cytoplasm. In this Review, we discuss the mechanisms of EJC formation, the many roles of the EJC in pre-mRNA and mRNA regulation and how these roles are influenced by EJC composition. This Review summarizes the various functions of the exon junction complex in RNA splicing and beyond, to influence gene regulation.
Keywords:
Exon junction complex
Pre-mRNA splicing
mRNA regulation
Gene regulation
Alternative modules
Journal
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IF:
10.1
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4.8K
Citations:
2.8W