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Genome-scale compositional comparisons in eukaryotes

delete2001-04-01
delete151
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Andrew J. Gentles
S
Samuel Karlin
DOI：10.1101/gr.163101delete
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Abstract

Abstract

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We examined dinucleotide relative abundances and their biases in recent sequences of eukaryotic genomes and chromosomes, including human chromosomes 21 and 22, Saccharomyces cerevisiae, Arabidopsis thaliana, and Drosophila melanogaster. We found that dinucleotide relative abundances are remarkably constant across human chromosomes and within the DNA of a particular species. The dinucleotide biases differ between species, providing a genome signature that is characteristic of the bulk properties of an organism's DNA. We detail the relations between species genome signatures and suggest possible mechanisms for their origin and maintenance.
Keywords:
PLANT ARABIDOPSIS-THALIANA
DNA-REPLICATION
SEQUENCE
DINUCLEOTIDES
SIGNATURE
FIDELITY
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Journal

Genome Research cover
Genome Research
IF:
5.5
Papers:
5.6K
Citations:
4.3W

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