Hen egg white lysozyme as a functional building block: structural features, assembly behavior, and emerging food applications

2025-12-29

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Lijuan Hou

Xiaozheng Liu *

Zhenyu Wang

Ruili Pan

Guangrong Huang

Xianjun Dai *

DOI：10.1016/j.tifs.2025.105521

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• HEWL is a natural antimicrobial protein whose defined structure and amphiphilic character confer remarkable structural adaptability. • Physicochemical mechanisms governing HEWL self-assembly are systematically summarized. • Diverse HEWL-based architectures-amyloid fibrils/nanotubes, microbubbles, hydrogels, micro/nanoparticles, emulsions, and films-are reviewed. • HEWL serves as a sustainable building block for multifunctional innovation in food formulation, active compound delivery, preservation, and biosensing. • Key challenges include structural heterogeneity, allergenicity, and biocompatibility.

Hen egg white lysozyme as a functional building block: structural features, assembly behavior, and emerging food applications

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