.png){kind=icon}
.png){kind=icon}
Return
Hypothalamic-hindbrain circuit for consumption-induced fear regulation
.png){kind=icon}
OA
AI
DOI：10.1038/s41467-024-51983-6.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
To ensure survival, animals must sometimes suppress fear responses triggered by potential threats during feeding. However, the mechanisms underlying this process remain poorly understood. In the current study, we demonstrated that when fear-conditioned stimuli (CS) were presented during food consumption, a neural projection from lateral hypothalamic (LH) GAD2 neurons to nucleus incertus (NI) relaxin-3 (RLN3)-expressing neurons was activated, leading to a reduction in CS-induced freezing behavior in male mice. LHGAD2 neurons established excitatory connections with the NI. The activity of this neural circuit, including NIRLN3 neurons, attenuated CS-induced freezing responses during food consumption. Additionally, the lateral mammillary nucleus (LM), which received NIRLN3 projections, along with RLN3 signaling in the LM, mediated the decrease in freezing behavior. Collectively, this study identified an LHGAD2-NIRLN3-LM circuit involved in modulating fear responses during feeding, thereby enhancing our understanding of how animals coordinate nutrient intake with threat avoidance. Nutrient intake and threat avoidance interact adaptively. Here, authors show a molecularly defined hypothalamus-to-hindbrain circuit responsible for the regulation of fear by feeding in male mice, representing a novel coordination mechanism.
Keywords:
CORTICOTROPIN-RELEASING-FACTOR
NUCLEUS-INCERTUS
LATERAL HYPOTHALAMUS
NEURAL CIRCUITS
MICE DISPLAY
NEURONS
RECEPTOR
BEHAVIORS
HUNGER
BRAIN
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.