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Hypoxia as a medicine

delete2025-01-22
delete4
PRE
AI
R
Robert S. Rogers
V
Vamsi K. Mootha *
DOI：10.1126/scitranslmed.adr4049delete
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Abstract

Abstract

En 中文
Oxygen is essential for human life, yet a growing body of preclinical research is demonstrating that chronic continuous hypoxia can be beneficial in models of mitochondrial disease, autoimmunity, ischemia, and aging. This research is revealing exciting new and unexpected facets of oxygen biology, but translating these findings to patients poses major challenges, because hypoxia can be dangerous. Overcoming these barriers will require integrating insights from basic science, high-altitude physiology, clinical medicine, and sports technology. Here, we explore the foundations of this nascent field and outline a path to determine how chronic continuous hypoxia can be safely, effectively, and practically delivered to patients.
Keywords:
ACUTE INTERMITTENT HYPOXIA
HYPERBARIC-OXYGEN THERAPY
MOUSE MODEL
CEREBRAL OXYGENATION
HIGHER ALTITUDES
ANIMAL-MODELS
NITRIC-OXIDE
MITOCHONDRIAL
EXERCISE
DISEASE

Journal

Science Translational Medicine cover
Science Translational Medicine
IF:
14.6
Papers:
4.9K
Citations:
5.3W

Organization

No organization information available