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Vamsi K. Mootha

harvard university medical affiliates

109H-index
367Paper Count
12.5WCitation Count
Published Papers 153
Publication Date
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Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
errNature
IF48.5
err2025-12-10
err0
errOAAI
errJoshua D. Meisel; Pallavi R. Joshi; Amy N. Spelbring; Hong Wang; Sandra M. Wellner; Presli P. Wiesenthal; Maria Miranda; Jason G. McCoy; David P. Barondeau; Gary Ruvkun; Vamsi K. Mootha
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errSave
Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-11-17
err1
errOAAI
errGuo, Rui; Sun, Yizhe; Lim, Matthew Y.; Shah, Hardik; Paulo, Joao A.; Ahmed, Rahaman A.; Li, Weixing; Zhang, Yuchen; Yang, Haopeng; Wang, Liang Wei; Strebinger, Daniel; Smith, Nicholas A.; Li, Meng; Leong, Merrin Man Long; Lutchenkov, Michael; Liang, Jin Hua; Li, Zhixuan; Wang, Yin; Puri, Rishi; Melnick, Ari; Green, Michael R.; Asara, John M.; Papathanassiu, Adonia E.; Wesemann, Duane R.; Gygi, Steven P.; Mootha, Vamsi K.; Gewurz, Benjamin E.
errShare
errSave
Hydrogen sulfide-dependent Activation of Human Sulfide Quinone Oxidoreductase
errJournal of Biological Chemistry
IF3.9
err2025-09-03
err0
errOAAI
errJoseph V. Roman; Yashvi Shukla; David A. Hanna; Mackenzie Mackson; Tsz-Leung To; Vamsi Mootha; Ruma Banerjee
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errSave
Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease
errNature Neuroscience
IF20
err2025-08-06
err0
errOAAI
errEizo Marutani; Maria Miranda; Timothy J. Durham; Sharon H. Kim; Dreson L. Russell; Presli P. Wiesenthal; Paul Lichtenegger; Marissa A. Menard; Charlotte F. Brzozowski; Haobo Li; Gary Ruvkun; Joshua D. Meisel; Laura Volpicelli-Daley; Vamsi K. Mootha; Fumito Ichinose
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errSave
Hypoxia as a medicine
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2025-01-22
err4
PREAI
errRogers, Robert S.; Mootha, Vamsi K.
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errSave
Cytosolic N6AMT1-dependent translation supports mitochondrial RNA processing
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-11-06
err0
errOAAI
errFoged, Mads M.; Recazens, Emeline; Chollet, Sylvain; Lisci, Miriam; Allen, George E.; Zinshteyn, Boris; Boutguetait, Doha; Muench, Christian; Mootha, Vamsi K.; Jourdain, Alexis A.
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errSave
Differential utilization of vitamin B12-dependent and independent pathways for propionate metabolism across human cells
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-09-01
err2
errOAAI
errGouda, Harsha; Ji, Yuanyuan; Rath, Sneha; Watkins, David; Rosenblatt, David; Mootha, Vamsi; Jones, Jace W.; Banerjee, Ruma
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errSave
Ironing out protein synthesis: METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
errBIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
IF2.7
err2024-09-01
err0
PREAI
errAst, Tslil; Itoh, Yuzuru; Sadre, Shayan; McCoy, Jason G.; Namkoong, Gil; Wengrod, Jordan C.; Chicherin, Ivan; Joshi, Pallavi R.; Kamenski, Piotr; Suess, Daniel L. M.; Amunts, Alexey; Mootha, Vamsi K.
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errSave
Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle
errJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
IF5.1
err2024-08-07
err0
errOAAI
errTamaroff, Jaclyn; Nguyen, Sara; Wilson, Neil E.; Stefanovski, Darko; Xiao, Rui; Scattergood, Theresa; Capiola, Christopher; Schur, Gayatri Maria; Dunn, Julia; Dedio, Anna; Wade, Kristin; Shah, Hardik; Sharma, Rohit; Mootha, Vamsi K.; Kelly, Andrea; Lin, Kimberly Y.; Lynch, David R.; Reddy, Ravinder; Rickels, Michael R.; McCormack, Shana E.
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errSave
Mitochondrial genome copy number variation across tissues in mice and humans
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-08-06
err0
errOAAI
errRath, Sneha P.; Gupta, Rahul; Todres, Ellen; Wang, Hong; Jourdain, Alexis A.; Ardlie, Kristin G.; Calvo, Sarah E.; Mootha, Vamsi K.
errShare
errSave
Nuclear genetic control of mtDNA copy number and heteroplasmy in humans (vol 620, pg 839, 2023)
errNATURE
IF48.5
err2024-06-03
err0
errOAAI
errGupta, Rahul; Kanai, Masahiro; Durham, Timothy J.; Tsuo, Kristin; McCoy, Jason G.; Kotrys, Anna V.; Zhou, Wei; Chinnery, Patrick F.; Karczewski, Konrad J.; Calvo, Sarah E.; Neale, Benjamin M.; Mootha, Vamsi K.
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errSave
CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene
errCURRENT BIOLOGY
IF7.5
err2024-06-01
err2
errOAAI
errMeisel, Joshua D.; Wiesenthal, Presli P.; Mootha, Vamsi K.; Ruvkun, Gary
errShare
errSave
Mechanism of Action and Translational Potential of (S)-Meclizine in Preemptive Prophylaxis Against Stroke
errSTROKE
IF8.9
err2024-05-01
err0
PREAI
errLee, Jeong Hyun; Gohil, Vishal M.; Heidari, Pedram; Seidel, Jessica L.; Zulkifli, Mohammad; Wei, Ying; Ji, Yuhua; Daneshmand, Ali; Mahmood, Umar; Clish, Clary B.; Mootha, Vamsi K.; Ayata, Cenk
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errSave
Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock
errMETABOLOMICS
IF3.3
err2024-03-06
err8
errOAAI
errRogers, Robert S.; Sharma, Rohit; Shah, Hardik B.; Skinner, Owen S.; Guo, Xiaoyan A.; Panda, Apekshya; Gupta, Rahul; Durham, Timothy J.; Shaughnessy, Kelsey B.; Mayers, Jared R.; Hibbert, Kathryn A.; Baron, Rebecca M.; Thompson, B. Taylor; Mootha, Vamsi K.
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errSave
Adaptations in mitochondrial metabolism render lipoate dispensable for human cell proliferation in hypoxia
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-03-01
err0
errOAAI
errJoshi, Pallavi; Skinner, Owen; Sadre, Shayan; Guo, Xiaoyan; Mootha, Vamsi
errShare
errSave
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics
errNATURE METABOLISM
IF20.8
err2024-02-27
err2
errOAAI
errTo, Tsz-Leung; Mccoy, Jason G.; Ostriker, Naomi K.; Sandler, Lev S.; Mannella, Carmen A.; Mootha, Vamsi K.
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errSave
ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits
errCELL METABOLISM
IF30.9
err2024-01-01
err5
PREAI
errSingh, Charandeep; Jin, Byungchang; Shrestha, Nirajan; Markhard, Andrew L.; Panda, Apekshya; Calvo, Sarah E.; Deik, Amy; Pan, Xingxiu; Zuckerman, Austin L.; Ben Saad, Amel; Corey, Kathleen E.; Sjoquist, Julia; Osganian, Stephanie; AminiTabrizi, Roya; Rhee, Eugene P.; Shah, Hardik; Goldberger, Olga; Mullen, Alan C.; Cracan, Valentin; Clish, Clary B.; Mootha, Vamsi K.; Goodman, Russell P.
errShare
errSave
METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
errMOLECULAR CELL
IF16.6
err2024-01-01
err9
errOAAI
errAst, Tslil; Itoh, Yuzuru; Sadre, Shayan; Mccoy, Jason G.; Namkoong, Gil; Wengrod, Jordan C.; Chicherin, Ivan; Joshi, Pallavi R.; Kamenski, Piotr; Suess, Daniel L. M.; Amunts, Alexey; Mootha, Vamsi K.
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errSave
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-09-01
err13
errOAAI
errJoshi, Pallavi R.; Sadre, Shayan; Guo, Xiaoyan A.; Mccoy, Jason G.; Mootha, Vamsi K.
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errSave
Continuous, but not intermittent, regimens of hypoxia prevent and reverse ataxia in a murine model of Friedreich's ataxia
errHUMAN MOLECULAR GENETICS
IF3.2
err2023-06-01
err6
errOAAI
errAst, Tslil; Wang, Hong; Marutani, Eizo; Nagashima, Fumiaki; Malhotra, Rajeev; Ichinose, Fumito; Mootha, Vamsi K.
errShare
errSave

Research Directions

No research directions
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