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Interpretable data integration for single-cell and spatial multi-omics
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DOI：10.1016/j.cels.2025.101479.png)
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Abstract
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• FGOT interpretably integrates single-cell or spatial transcriptomic and epigenomic data • FGOT reveals cell or spatial heterogeneity and their transcriptional regulatory links • FGOT identifies cell-state-specific cis-regulatory elements at single-cell or spot level • FGOT extends downstream analyses for existing multi-omics data integration methods
Keywords:
optimal transport
multi-omics integration
transcriptional regulatory
single cell
spatial genomics
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