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Learn from microbial intelligence for avermectins overproduction
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DOI：10.1016/j.copbio.2017.08.016.png)
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Abstract
En 中文
Microbial strains are amazingly clever by homeostasis of their own survival and optimization for the overproduction of a desired phenotype, for example drugable secondary metabolites through coordination of key genes overexpression and media optimizations. Besides their pesticide activities, avermectins(AVMs) are identified as potent antibiotic agents for a wide range of drug-resistant pathogens by a high throughput synergy screening strategy. To rewire the genetic circuitry controlling low yields, we summarized the work on balancing the biological chassis with functional parts, and optimized their dynamical process, as well as predicted favorable effective overproduction of AVMs by 5Ms strategy. AVMs are exclusively made in China now and intelligences learned from the success of AVMs will help transform microbes into a true power-house of innovation.
Keywords:
STRAIN STREPTOMYCES-AVERMITILIS
INDUSTRIAL STRAIN
ANTIBIOTIC PRODUCTION
AUTOREGULATOR RECEPTOR
NATURAL-PRODUCTS
REGULATORY GENE
SIGMA-FACTOR
BIOSYNTHESIS
EXPRESSION
CHINA
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