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Mechanistic insights into acid-induced viable but non-culturable state formation regulated by asr in Escherichia coli O157:H7: roles of intracellular protein aggregation

delete2026-06-11
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PRE
AI
X
Xinyu Ma
Y
Yanan Wu
J
Jiajing Zhang
J
Jun Li
Q
Qing Ren
H
Hanxu Pan *
Z
Zhanbin Sun *
DOI：10.1016/j.fm.2026.105200delete
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Abstract

Abstract

En 中文
• Asr caused pHin imbalance in VBNC formation of E. coli O157:H7 under acid/HPCD. • Reduced pHin triggered protein aggregation to decrease cellular ATP levels. • asr deletion inhibited protein aggregation and thereby accelerated bacterial death. • asr-mediated proteostasis disruption facilitated acid/HPCD-induced VBNC formation.

Journal

Food Microbiology cover
Food Microbiology
IF:
4.6
Papers:
421
Citations:
1.5W

Organization

B
Beijing Technology and Business University
Scholars:
3.6K
Papers: 1.6K
Citations: 1.6W
C
China National Center for Food Safety Risk Assessment
Scholars:
207
Papers: 114
Citations: 1.9K
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