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Mechanistic insights into the lipid-lowering effects of phycocyanin through human intestinal and liver organoids
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DOI：10.1016/j.crfs.2026.101502.png)
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Abstract
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• Phycocyanin suppresses chylomicron secretion in intestinal organoids. • Peptidomics revealed a novel phycocyanin peptide profile after simulated digestion. • One of the digested phycocyanin peptides, MKTPL, inhibits chylomicron secretion. • Digested phycocyanin and MKTPL reduce VLDL secretion in liver organoids.
Keywords:
Phycocyanin
Human intestinal organoids
Human liver organoids
Chylomicron
Very-low-density lipoprotein
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