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Memory traces unbound
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DOI：10.1016/S0166-2236(02)00042-5.png)
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Abstract
En 中文
The idea that new memories are initially 'labile' and sensitive to disruption before becoming permanently stored in the wiring of the brain has been dogma for >100 years. Recently, we have revisited the hypothesis that reactivation of a consolidated memory can return it to a labile, sensitive state - in which it can be modified, strengthened, changed or even erased! The data generated from some of the best-described paradigms in memory research, in conjunction with powerful neurobiological technologies, have provided striking support for a very dynamic neuro-biological basis of memory, which is beginning to overturn the old dogma.
Keywords:
LONG-TERM-MEMORY
RETROGRADE-AMNESIA
PROTEIN-SYNTHESIS
REACTIVATED MEMORY
CONTEXTUAL FEAR
RETRIEVAL
AMYGDALA
CONSOLIDATION
EXTINCTION
RECONSOLIDATION
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