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Microscopy with microfluidics in microgravity using FlightScope

delete2025-05-06
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OA
AI
T
Thomas Wareing
A
Alexander Stokes
K
Katrina E Crompton
K
Koren Murphy
J
Jack Dawson
Y
Yusuf Furkan Ugurluoglu
C
Connor Richardson
H
Hongquan Li
M
Manu Prakash
A
Adam J. M. Wollman *
DOI:10.1038/s41526-025-00470-3delete
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Abstract

Abstract

En 中文
With planned missions to the moon and Mars, it has never been more important to study the impact of microgravity on biological organisms. Parabolic flights are one of the most accessible microgravity research platforms but present challenges: short periods of microgravity and aircraft vibration. Live-imaging is necessary to readout any real-time phenotypes so we developed FlightScope, a new microscopy and microfluidics platform to study dynamic cellular processes in microgravity.
Keywords:
DIGITAL HOLOGRAPHIC MICROSCOPY
COMPACT
CELLS
LENS

Journal

NPJ Microgravity cover
NPJ Microgravity
IF:
4.1
Papers:
688
Citations:
1.9K

Organization

N
Newcastle Univ
Scholars:
936
Papers: 523
Citations: 270
Cited Papers

Cited Papers

Real-Time Video-Microscopy of Migrating Immune Cells in Altered Gravity During Parabolic Flights
err2009-04-18
err0
PREAI
errKerstin Lang; Carina Strell; Bernd Niggemann; Kurt S. Zänker; Andre Hilliger; Frank Engelmann; Oliver Ullrich
errShare
errSave
Growth and Form of Planetary Seedlings: Results from a Microgravity Aggregation Experiment
err2000-09-18
err0
errOAAI
errJ. Blum; G. Wurm; S. Kempf; T. Poppe; H. Klahr; T. Kozasa; M. Rott; T. Henning; J. Dorschner; R. Schräpler; H. U. Keller; W. J. Markiewicz; I. Mann; B. A. S. Gustafson; F. Giovane; D. Neuhaus; H. Fechtig; E. Grün; B. Feuerbacher; H. Kochan; L. Ratke; A. El Goresy; G. Morfill; S. J. Weidenschilling; G. Schwehm; K. Metzler; W.-H. Ip
errShare
errSave
Digital holographic microscopy real-time monitoring of cytoarchitectural alterations during simulated microgravity
err2010-03-01
err31
errOAAI
errPache, Christophe; Kuehn, Jonas; Westphal, Kriss; Toy, M. Fatih; Parent, Jerome; Buechi, Oralea; Franco-Obregon, Alfredo; Depeursinge, Christian; Egli, Marcel
errShare
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Yeast AMP-activated Protein Kinase Monitors Glucose Concentration Changes and Absolute Glucose Levels
err2014-05-01
err38
errOAAI
errBendrioua, Loubna; Smedh, Maria; Almquist, Joachim; Cvijovic, Marija; Jirstrand, Mats; Goksor, Mattias; Adiels, Caroline B.; Hohmann, Stefan
errShare
errSave
High-speed volumetric imaging of neuronal activity in freely moving rodents
err2018-05-07
err169
errOAAI
errSkocek, Oliver; Nobauer, Tobias; Weilguny, Lukas; Traub, Francisca Martinez; Xia, Chuying Naomi; Molodtsov, Maxim, I; Grama, Abhinav; Yamagata, Masahito; Aharoni, Daniel; Cox, David D.; Golshani, Peyman; Vaziri, Alipasha
errShare
errSave
Feasibility of a low-cost sounding rockoon platform
err2016-10-01
err10
PREAI
errOkninski, Adam; Sors Raurell, Daniel; Rodriguez Mitre, Alberto
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Module to Support Real-Time Microscopic Imaging of Living Organisms on Ground-Based Microgravity Analogs
err2021-04-01
err0
errOAAI
errSrujana Neelam; Audrey Lee; Michael A. Lane; Ceasar Udave; Howard G. Levine; Ye Zhang
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Microgravity Modulates Effects of Chemotherapeutic Drugs on Cancer Cell Migration
err2020-08-24
err18
errOAAI
errPrasanth, Devika; Suresh, Sindhuja; Prathivadhi-Bhayankaram, Sruti; Mimlitz, Michael; Zetocha, Noah; Lee, Bong; Ekpenyong, Andrew
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