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Multifunctional RNA Nanoparticles

delete2014-09-30
delete193
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OA
AI
K
Kirill A. Afonin
M
Mathias Viard
A
Alexey Y. Koyfman
A
Angélica N. Martins
W
Wojciech K. Kasprzak
M
Martin Panigaj
R
Ravi A. Desai
A
Arti Santhanam
W
Wade W. Grabow
L
Luc Jaeger
E
Eliahu Heldman
J
Jakob Reiser
W
Wah Chiu
E
Eric O. Freed
B
Bruce A. Shapiro *
DOI:10.1021/nl502385kdelete
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Abstract

Abstract

En 中文
Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNADNA hybrids aimed to conditionally activate multiple split functionalities inside cells.
Keywords:
RNA nanotechnology
RNA nanoparticles
RNA interference
aptamers
RNA-DNA hybrid reassociation
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Journal

Nano Letters cover
Nano Letters
IF:
9.1
Papers:
2.7W
Citations:
16.5W

Organization

N
national institutes of health (nih) - usa
Scholars:
10.3W
Papers: 8.2W
Citations: 111
F
Frederick National Laboratory for Cancer Research
Scholars:
2.0K
Papers: 1.2K
Citations: 5.8K
B
Baylor College of Medicine
Scholars:
4.1W
Papers: 3.0W
Citations: 4.2W
N
nih national cancer institute (nci)
Scholars:
2.1W
Papers: 1.6W
Citations: 27
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