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Multifunctional RNA Nanoparticles
DOI:10.1021/nl502385k.png)
Abstract
En 中文
Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNADNA hybrids aimed to conditionally activate multiple split functionalities inside cells.
Keywords:
RNA nanotechnology
RNA nanoparticles
RNA interference
aptamers
RNA-DNA hybrid reassociation
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