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Multiple protein structure alignment at scale with FoldMason
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DOI：10.1126/science.ads6733.png)
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Abstract
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Protein structures can preserve information about evolutionary relationships that are no longer possible to detect by sequence alone. However, aligning by structure is computationally intensive, and with the advent of large-scale structure prediction, there is a need for tools that can efficiently align vast numbers of structures. Gilchrist et al. present FoldMason, a tool designed for this purpose that is based on parallelized progressive alignment. This approach permits large-scale phylogenetic analyses for protein families that have conserved structure but limited sequence conservation. —Michael A. Funk