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Network-based drug repurposing for psychiatric disorders using single-cell genomics
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DOI：10.1016/j.xgen.2025.101003.png)
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Abstract
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• Cell-type-specific gene regulators in psychiatric disorders are identified • Graph neural networks identified novel risk genes and drug candidates • Evidence of therapeutic effect for 37 drugs • Discovered 335 cell-type-specific eQTLs linking genetic variation to drug targets
Keywords:
psychiatric disorders
drug repurposing
single-cell network medicine
cell-type-disorder genes
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