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Neuroprotective effect of syringaldehyde in chronic unpredictable mild stress-induced model of depression
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DOI：10.1016/j.lmot.2025.102233.png)
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Abstract
En 中文
Purpose of the research: The impact of traumatic experiences and chronic stress on the onset of depression has been the subject of numerous studies. The major etiology that is thought to eventually lead to depression involves the monoamines, neurotrophic, and neuroinflammation hypothesis. The purpose of this research work was to evaluate the effect of Syringaldehyde (SA) in CUMS-induced animal model of depression. Male Swiss albino mice were used for this study. The CUMS model was used as an inducer and fluoxetine was used as a standard drug for the study purpose. Principal results: The antidepressant activity was assessed by performing the Sucrose preference, Actophotometer, Tail suspension, and Forced swim tests. In addition, the levels of Serotonin, BDNF, and Interleukin-6 were estimated via the ELISA method using the mice whole brain homogenate. SA also showed an improvement against locomotor activity, immobility time, and sucrose preference in mice. For low, intermediate, and high doses of SA, the results were found to be significant (p < 0.05, p < 0.01, and p < 0.001). This study showed that the administration of SA exhibits anti-depressant activity, which is related, at least partly, to its elevated Brain-derived neurotrophic factor levels. The results showed that SA treatment increased neurotransmitters (serotonin) and reduced pro-inflammatory cytokines (IL-6). Major conclusions: Thus, it can be concluded that at such 12.5 mg/kg, SA has notable anti-depressant effects. SA might be targeted to slow or prevent neurodegeneration and neuroinflammation in depression and potentially other neurodegenerative diseases.
Keywords:
Depression
brain-derived neurotropic factor
Syringaldehyde
serotonin
Interleukin-6
Journal
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IF:
1.8
Papers:
66
Citations:
1.4K
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