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Novel 1-Phenyl-2; 3-dihydroquinazolin-4(1H)-one Derivatives as Nav 1.8 Voltage-Gated Sodium Channels Inhibitors
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DOI：10.1021/acsmedchemlett.6c00189.png)
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Abstract
En 中文
This highlight outlines the development of novel substituted 1-phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives as potential inhibitor candidates for Nav 1.8 voltage-gated sodium channels (Nav 1.8), which is upregulated or activated to transmit nociceptive signaling in a range of pain-related disorders. The invention includes details on preparation methods, biological activity assays, and pharmaceutical compositions.
Keywords:
1-Phenyl-2,3-dihydroquinazolin-4(1H)-one
Nav 1.8
voltage-gated sodium channels
pain-related disorders
inhibitor candidates