.png){kind=icon}
.png){kind=icon}
Return
Novel hybrid 1,4-naphthoquinone-endoperoxide antimalarial hits: synthesis, stereoisomeric separation, and biological evaluation
.png){kind=icon}
OA
AI
A
S
N
O
C
P
T
N
DOI：10.1016/j.ejmech.2026.118926.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• First naphthoquinone-endoperoxide dual-pharmacophore antimalarial hybrids • Mn(III)-mediated peroxycyclization enabled access to stereoisomeric series • Full stereoisomer resolution was achieved by preparative chiral HPLC • Stereochemistry significantly influenced potency (3-fold) and selectivity (9-fold) • Lead exhibited IC50 0.49 μM against MDR P. falciparum W2 with SI >250 on CHO
Keywords:
naphthoquinone
endoperoxide
antimalarial
stereoisomers
hybrid compounds
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
5.9
Papers:
1.7W
Citations:
6.0W
Organization
Cited Papers