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Novel PROTACs with polyhedral alkanes as linkers for enhanced ALK degradation in drug-resistant NSCLC
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DOI：10.1016/j.bmc.2025.118521.png)
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Abstract
En 中文
• Polyhedral alkanes were used as linkers for the first time in PROTACs targeting ALK. • HAPOD trail was firstly used to assess the feasibility of PROTACs targeting ALK designing. • Five new PROTACs targeting ALK were synthesized via established organic synthesis routes. • Cell proliferation inhibition assay and Western blotting assay were used in vitro. • Molecular Dynamic Simulation analysis was used in silico.
Journal
B
IF:
3
Papers:
1.7W
Citations:
2.7W
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Cited Papers