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PharmVar GeneFocus: CYP2D6
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DOI：10.1002/cpt.1643.png)
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Abstract
En 中文
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).
Keywords:
PHARMACOGENETICS IMPLEMENTATION CONSORTIUM
DRUG-METABOLIZING-ENZYMES
HUMAN CYTOCHROME-P450 2D6
CLINICAL-SIGNIFICANCE
CPIC GUIDELINE
PHENOTYPE ASSIGNMENT
GENETIC-VARIATION
NO-CALL
ALLELE
DEBRISOQUINE
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