PRPP Allocation-Centered Microbial Biomanufacturing of Nucleosides: Metabolic Engineering, AI-DBTL, and Food-Grade Industrialization Challenges

Tong Ye

doi:10.1016/j.tifs.2026.105978

PRPP Allocation-Centered Microbial Biomanufacturing of Nucleosides: Metabolic Engineering, AI-DBTL, and Food-Grade Industrialization Challenges

2026-08-06

0

PRE

AI

T

Tong Ye

J

Junnan Xu

魏晓博 (Xiaobo Wei)

W

Wei Ding *

刘慧燕 (Huiyan Liu) *

方海田 (Haitian Fang) *

DOI：10.1016/j.tifs.2026.105978

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• PRPP allocation as the central hub for integrating nucleoside synthesis, precursor competition, and growth regulation • Multi-target coordination: enhancing precursor supply while blocking degradation pathways • AI and multi-omics show promise for predictive enzyme design and fermentation control • Rational design with automated platforms may accelerate nucleoside cell factory iteration • Orthogonal systems and biofoundries require further industrial validation

PRPP Allocation-Centered Microbial Biomanufacturing of Nucleosides: Metabolic Engineering, AI-DBTL, and Food-Grade Industrialization Challenges

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