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Real-time breath metabolomics to assess early response to CFTR modulators in adults with cystic fibrosis: An open-label proof-of-concept study
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DOI：10.1016/j.jcf.2026.06.013.png)
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Abstract
En 中文
• ETI induces rapid, measurable changes in exhaled volatile organic compounds. • Breath VOCs shift towards healthy levels within one week of ETI initiation. • Real-time PTR-MS enables non-invasive, point-of-care breath monitoring in CF. • Multilevel statistics identify monotonous and non-monotonous VOC trajectories. • Ten VOCs correlate with lung function and sweat chloride.tab.
Keywords:
Breathomics
Cystic fibrosis
CFTR modulators
Real-time mass spectrometry
Volatile organic compounds
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