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Real-time deformability cytometry: on-the-fly cell mechanical phenotyping
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DOI：10.1038/nmeth.3281.png)
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Abstract
En 中文
We introduce real-time deformability cytometry (RT-DC) for continuous cell mechanical characterization of large populations (> 100,000 cells) with analysis rates greater than 100 cells/s. RT-DC is sensitive to cytoskeletal alterations and can distinguish cell-cycle phases, track stem cell differentiation into distinct lineages and identify cell populations in whole blood by their mechanical fingerprints. This technique adds a new marker-free dimension to flow cytometry with diverse applications in biology, biotechnology and medicine.
Keywords:
RED-BLOOD-CELLS
SINGLE-CELLS
DIFFERENTIATION
SHAPE
METHYLCELLULOSE
DYNAMICS
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