Persistence of large P. aeruginosa aggregates despite reduced airway burden in people with cystic fibrosis on CFTR modulator therapy

Amanda J. Morris

doi:10.1016/j.jcf.2026.06.012

Real-world experience with a generic formulation of elexacaftor/tezacaftor/ivacaftor in children with cystic fibrosis

2026-07-19

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M

María Macarena Oneglia *

H

H. Giugno

A

A. Agustinho

P

Paula Plubatsch

C

Claudio Castaños

DOI：10.1016/j.jcf.2026.07.004

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Abstract

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• Generic triple modulator therapy was evaluated in children with cystic fibrosis. • Lung function and nutritional status improved; sweat chloride decreased. • Pulmonary exacerbations and Pseudomonas aeruginosa in sputum decreased. • Few adverse effects were reported. • Argentine generic formulation showed similar results to the branded treatment.

Real-world experience with a generic formulation of elexacaftor/tezacaftor/ivacaftor in children with cystic fibrosis

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