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Scanning system for angle-resolved low-coherence interferometry
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DOI：10.1364/OL.42.004581.png)
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Abstract
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Angle-resolved low-coherence interferometry (a/LCI) detects precancer by enabling depth-resolved measurements of nuclear morphology in vivo. A significant limitation of a/LCI is the point-probe nature of the method, sampling <0.5 mm(2) before probe relocation is necessary. In this work, we demonstrate a scanning method capable of assessing an area > 100 mm(2) without repositioning. By utilizing a reflection-only three-optic rotator prism and a two-axis scanning mirror, we demonstrate radial scans of a sample with a linear range of 12 mm and a full rotational range of 180 degrees. Use of this design will improve the diagnostic utility of a/LCI for wide-area screening of tissue health. (C) 2017 Optical Society of America
Keywords:
NUCLEAR MORPHOLOGY
BARRETTS-ESOPHAGUS
CLINICAL DETECTION
DYSPLASIA
EPITHELIUM
Journal
IF:
3.3
Papers:
4.0W
Citations:
7.6W
Organization
Cited Papers
Cellular organization and substructure measured using angle-resolved low-coherence interferometry.png)
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