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Single-cell transcriptomics reveals heterogeneous stress responses and Mg2+-mediated survival mechanisms in Lactobacillus delbrueckii subsp. bulgaricus during freeze-drying and storage
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DOI：10.1016/j.foodres.2026.120273.png)
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Abstract
En 中文
• scRNA-seq reveals functionally distinct clusters in L. bulgaricus. • Genomic integrity and energy homeostasis appeared to be important determinants of survival during freeze-drying and storage. • Mg2+ increases survival 2-fold after freeze-drying and 5-fold after storage. • Mg2+ supplementation correlated with preservation of translation, DNA repair, and central carbon metabolism during freeze-drying and storage.
Keywords:
Single-cell RNA sequencing
Freeze-drying
Heterogeneous stress responses
Journal
IF:
8
Papers:
1.7W
Citations:
7.9W
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