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Somatic IRF4 mutations and thymic tropism in primary mediastinal large B-cell lymphoma

delete2025-06-24
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OA
AI
S
Shinya Rai
G
Gerben Duns
F
Fabian Frontzek
J
Jasper Wong
Y
Yifan Yin
M
Michael Y. Li
M
Makoto Kishida
M
Manabu Fujisawa
S
Shannon Healy
E
Elena Viganò
A
Aixiang Jiang
B
Bruce W. Woolcock
A
Adèle Telenius
S
Susana Ben‐Neriah
B
Barbara Meissner
M
Merrill Boyle
H
Hisae Nakamura
L
Luke O’Brien
C
Claudia Cassidy
A
Andrew Lytle
P
Pedro Farinha
G
Graham W. Slack
L
Laura K. Hilton
R
Ryan D. Morin
L
Leandro Venturutti
T
Tomohiro Aoki
N
Nicole Wretham
J
Jonathan W. Bush
L
Laura Evgin
K
Kerry J. Savage
D
David W. Scott
C
Christian Steidl *
DOI：10.1182/blood.2025028412delete
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Abstract

Abstract

En 中文
• IRF4-C99R mutations are recurrent in PMBCL and lead to a differentiation block, elevated TARC expression, and regulatory T-cell chemotaxis. • IRF4 mutation–associated upregulation of EPHB1 leads to lymphoma organotropism favoring thymic involvement.

Journal

Blood cover
Blood
IF:
23.1
Papers:
5.4K
Citations:
16.6W

Organization

T
The University of British Columbia
Scholars:
964
Papers: 460
Citations: 0
S
Simon Fraser University
Scholars:
1.0W
Papers: 1.0W
Citations: 1.4W
B
british columbia cancer research institute
Scholars:
31
Papers: 15
Citations: 0
B
british columbia cancer
Scholars:
32
Papers: 5
Citations: 0
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