.png){kind=icon}
.png){kind=icon}
Return
Systematic Chemogenetic Library Assembly
.png){kind=icon}
OA
AI
DOI：10.1016/j.chembiol.2020.07.004.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Chemogenetic libraries, collections of well-defined chemical probes, provide tremendous value to biomedical research but require substantial effort to ensure diversity as well as quality of the contents. We have assembled a chemogenetic library by data mining and crowdsourcing institutional expertise. We are sharing our approach, lessons learned, and disclosing our current collection of 4,185 compounds with their primary annotated gene targets (https://github.com/Novartis/MoaBox). This physical collection is regularly updated and used broadly both within Novartis and in collaboration with external partners.
Keywords:
QUANTITATIVE PRIORITIZATION
TOOL COMPOUNDS
DISCOVERY
CELLS
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.