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Temporal and spatial omics technologies for 4D profiling

delete2025-04-22
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PRE
AI
D
David E. Reynolds
Y
Yoon Ho Roh
D
Daniel Oh
P
Phoebe Vallapureddy
R
Rong Fan
DOI：10.1038/s41592-025-02683-6delete
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Abstract

Abstract

En 中文
Cells have distinct molecular repertoires on their surfaces and unique intracellular biomolecular profiles that play pivotal roles in orchestrating a myriad of biological responses in the context of growth, development and disease. A persistent challenge in the deep exploration of these cues has been in our inability to effectively and precisely capture the temporal and spatial characteristics of living cells. In this Perspective, we delve into techniques for temporal and two- and three-dimensional spatial omics analyses and underscore how their harmonious fusion promises to unlock insights into the dynamics and diversity of individual cells within biological systems such as tissues and organoids. We then explore four-dimensional profiling, a nascent but promising frontier that adds a temporal (fourth-dimension) component to three-dimensional omics; highlight the advancements, challenges and gaps in the field; and discuss potential strategies for further technological development.
Keywords:
GENOME-WIDE EXPRESSION
MESSENGER-RNA-SEQ
SINGLE-CELL
GENE-EXPRESSION
VISUALIZATION
CHALLENGES
MODELS
TISSUE
ATLAS

Journal

Nature Methods cover
Nature Methods
IF:
32.1
Papers:
7.2K
Citations:
12.7W

Organization

No organization information available