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The Initiation of Eukaryotic DNA Replication
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DOI：10.1146/annurev-biochem-072321-110228.png)
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Abstract
En 中文
DNA replication in eukaryotic cells initiates from large numbers of sites called replication origins. Initiation of replication from these origins must be tightly controlled to ensure the entire genome is precisely duplicated in each cell cycle. This is accomplished through the regulation of the first two steps in replication: loading and activation of the replicative DNA helicase. Here we describe what is known about the mechanism and regulation of these two reactions from a genetic, biochemical, and structural perspective, focusing on recent progress using proteins from budding yeast.
Keywords:
ORIGIN RECOGNITION COMPLEX
CYCLIN-DEPENDENT KINASES
HIGH-FREQUENCY TRANSFORMATION
LEADING-STRAND SYNTHESIS
S-PHASE
CMG HELICASE
SACCHAROMYCES-CEREVISIAE
STRUCTURAL BASIS
MCM2-7 HELICASE
CELL-CYCLE
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