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Transcriptome-wide association studies at cell-state level using single-cell eQTL data
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DOI：10.1016/j.xgen.2025.101060.png)
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Abstract
En 中文
• TWiST captures cell states in single-cell TWAS analysis • Outperforms pseudobulk methods in statistical power • Flexible tests of global, dynamic, and nonlinear effects • Dynamic gene-autoimmune disease association along cell differentiation trajectory
Keywords:
transcriptome-wide association studies
single-cell eQTL
cell state
dynamic effect
autoimmune disease
genetics
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