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What are tethering elements?
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DOI：10.1016/j.gde.2023.102151.png)
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Abstract
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High-resolution Micro -C maps identified a specialized class of regulatory DNAs termed 'tethering elements' (TEs) in Drosophila. These 300-500-bp elements facilitate specific long -range genomic associations or loops. The POZ-containing transcription factor GAF (GAGA -associated factor) contributes to loop formation. Tether-tether interactions accelerate Hox gene activation by distal enhancers, and coordinate transcription of duplicated genes (paralogs) through promoter-promoter associations. Some TEs engage in ultra -long -range enhancer-promoter and promoter-promoter interactions (meta-loops) in the Drosophila brain. We discuss the basis for tether-tether specificity and speculate on the occurrence of similar elements in vertebrate genomes.
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GENE-REGULATION
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