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AAPS Journal cover

AAPS Journal

IF3.7
Papers2291
Citations7462
Journal Papers 2369
Publication Date
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Liquid Chromatography/tandem Mass Spectrometry-based Target Engagement of Lysine-specific Demethylase 1 Inhibitor TAK-418 Through Detecting Covalent Adducts in the Brain
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IF3.7
delete2026-10-12
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deleteKota Matsumiya; Shinji Iwasaki; Satoru Matsuda; Yohei Kosugi; Hisao Shimizu; Masaaki Kakehi; Rina Baba; Nobuyuki Amano; Atsushi Nakatani; Haruhide Kimura; Hideki Hirabayashi
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Physiologically based Biopharmaceutics Modeling (PBBM) Reveals a Low Dissolution-related Bioequivalence Risk for Immediate-Release Amlodipine Tablets
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IF3.7
delete2026-10-12
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deletePorfirio de la Cruz Cruz; Larissa Lopes Rodrigues Gomide; Gabriela Moraes do Nascimento; José Trinidad Pérez Urizar; Alberto Martínez Muñoz; Ángel Antonio Vértiz Hernández; Amaury de Jesús Pozos Guillén; Héctor Eduardo Flores Reyes; Ricardo Zamora Ramírez; Luis Manuel Romero Cruz; Marcelino García Sánchez; Mauricio A. García; Michele Georges Issa; Marcelo Dutra Duque
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Nanocarrier-Enabled Delivery of Glucosinolates for Skin Cancer Prevention and Therapy
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IF3.7
delete2026-10-07
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deleteChandrika Chaturvedi; Carman Giacomantonio; H. P. Vasantha Rupasinghe
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Insights into Drug Absorption Impairment Mechanisms in Hepatic Impairment using Physiologically-based Pharmacokinetic Modelling: A Case Study with Nilotinib
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IF3.7
delete2026-10-07
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deleteLaura G. Al-Amiry Santos; Chara Litou; Karen Rowland Yeo
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Statistical Tools for Biosimilarity Assessment: A Perspective Based on WHO-recommended Approaches
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IF3.7
delete2026-10-07
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deleteAnurag S. Rathore; Anuj Shrivastava
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Utilization of Brain Physiologically Based Pharmacokinetic Modeling in Support of CNS Drug Development: Case Example of Fenebrutinib
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IF3.7
delete2026-10-05
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deleteChristine M. Bowman; Fang Ma; Yan Xu; Denison Kuruvilla; Lin Pan; Matthew R. Durk; Yuan Chen
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Population Pharmacokinetics and Exposure–response Analysis of Durvalumab in Patients with Limited-stage Small-cell Lung Cancer in the Phase 3 ADRIATIC Study
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IF3.7
delete2026-09-28
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deleteHong Su; Becky Jiajia Zhao; Yu Fu; Yan-Yan Zhang; Priti Chugh; Ed Casson; KyoungSoo Lim; Song Ren; Diansong Zhou; Peiming Ma; Chunling Fan
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NCA Assistant: An Open-source R/Shiny Interface for Non-compartmental Pharmacokinetic Analysis, Bioequivalence Testing and Study Planning
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IF3.7
delete2026-09-28
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deleteRob ter Heine
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Challenges in the Quantification of Free TFPI in Human Plasma Following Marstacimab Treatment
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IF3.7
delete2026-09-22
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deleteKatherine Wright; Kerry Kelleher; Parya Nouri; Lindsay King; Hendrik Neubert
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Synonymous Gene Recoding Affects the Accuracy of Protein Quantification Measurements
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IF3.7
delete2026-09-21
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deleteNayiri M. Kaissarian; Nigam Padhiar; Nathan Clement; Wells W. Wu; Upendra Katneni; Anton A. Komar; Chava Kimchi-Sarfaty
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Benchmarking Automated Mass Photometry against SEC-MALS and AUC for Quantifying Cross-Linked Monoclonal Antibody Aggregates
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IF3.7
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deleteMingyue Li; Sharon Polleck; Cliff Entrican; Cassandra Larkin; Brenda Watt; Elizabeth McCoy
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Immunogenicity Profile of Lonapegsomatropin During Long-Term Treatment in Children With Growth Hormone Deficiency
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IF3.7
delete2026-09-21
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deletePer Holse Mygind; Amiee Weiser; Camilla Melin Fürst; Allison S. Komirenko; Meng Mao; Aimee D. Shu; Vibeke Miller Breinholt
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Minimum Significant Ratio for Defining Treatment-Boosted ADA Responses Using Signal-to-Noise as an Alternative to Titer
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IF3.7
delete2026-09-21
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deleteLili Guo; Kenneth Goldberg; Yong Jiang; Christopher Ehlinger
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Quantitative Characterization of Innate and Adaptive Pharmacology of Allogeneic anti-CD20 Chimeric Antigen Receptor (CAR) Vδ1 γδ T cells using Multiscale Mechanistic Modeling
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IF3.7
delete2026-09-18
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deleteDevam A. Desai; Omar Elashkar; Rodrigo Cristofoletti; Ganesh Mugundu; Aman P. Singh
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Impact of Extraction Recovery and Matrix Effect on qPCR-based Biodistribution Analysis in Gene Therapy: Strategies for Mitigation
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IF3.7
delete2026-09-18
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deleteTing Jiang; Zhaomeng Feng; Long Yuan
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Investigating the Role of Phenolic Acid Coformers in Enhancing the Physicochemical Properties of Enzalutamide Coamorphous Systems
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IF3.7
delete2026-09-18
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deleteVenkata Krishna Rao Balaga; Argyro Chatziadi; Luděk Ridvan; Miroslav Šoóš
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A Proposal for the Use of an Innovative Two-Stage PK-Clinical Adaptive Trial in Biosimilar Product Development
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IF3.7
delete2026-09-18
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deleteWeijia Mai; Shein-Chung Chow
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Artificial Intelligence in Pharmaceutical Regulatory Science: Opportunities, Challenges, and Emerging Frameworks
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IF3.7
delete2026-09-18
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deleteInês Lucas; João Sousa; Carla Vitorino
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Area Under the Curve-Guided Therapeutic Drug Monitoring of Mycophenolic Acid in Lung Transplant Recipients: Volumetric Absorptive Microsampling and Population Pharmacokinetic-Based Limited Sampling Strategies
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IF3.7
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deleteLiang Juan; Manjunath P. Pai; Chao-Wen Lu; Ching-Hua Kuo; Hsao-Hsun Hsu; Shu-Wen Lin; Yu-Ju Tseng
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A Novel Assay Platform for Targeted Protein Degradation Monitoring: Case Study of Antibody Free Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) for MALT1 Target Quantification
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IF3.7
delete2026-09-15
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deleteFeng Jin; Craig Wallace; William Housley; Marlon Cowart; Lucia Eaton; John P. Savaryn; David B. Duignan; Christopher M. Harris; Mario Richter; Gary J. Jenkins; Qin C. Ji
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