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Medical Hypotheses

IF0.8
Papers185
Citations8791
Journal Papers 185
Publication Date
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IL-17 signaling accelerates osteoarthritis progression in metabolic syndrome: A hypothesis
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delete2026-06-01
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deleteZhang, Dongyang; Tang, Yong; Dong, Fengqin; Shi, Guohua; Wei, Qiangqiang
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Altered hypothalamic temperature regulation as an upstream vulnerability mechanism in autism spectrum disorder
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deleteGabbay, Uri; Carmi, Doron
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Could targeting the gut-liver-bone axis prevent both MASLD and osteoporosis? A translational scientific hypothesis
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deleteRen, Shi-Hong; Wang, Xiang-Hu; He, Lian-Ping
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Lipid raft hypothesis on minzasolmin altering α-synucleinopathy in Parkinson's disease
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deleteRoy, Abhideep; Borah, Anupom; Bhattacharya, Pallab
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The neuroendocrine-brain immune axis in non-small cell lung cancer: a hypothesis on endocrine autoimmunity and CNS immune surveillance
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deleteTanriverdi, Ozgur
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Speed as a compensatory stabilizer: the momentum-dependent hypothesis of pediatric gait maturation and its implications for hidden motor deficits
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deleteTapanya, Weerasak; Sangkarit, Noppharath
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Heel fat pad may be with tendon repair functions and play an important role in the pathogenesis of plantar fasciitis
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deleteLiu, Yu-Ping; Duan, Xiu-Fang; Li, Miao-Miao; Li, Wei; Chen, Ze; Li, Lin; Li, Hua
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Growth differentiation factor 15 activation of AMPK modulates choline/ TMAO-driven calcific aortic valve disease: a novel therapeutic strategy for aortic stenosis
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deleteLi, Shao-Jung; Cheng, Tzu-Yu; Trang, Nguyen Ngoc; Chen, Yi-Jen
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Insulin resistance as a decision of the cellular living system: From the evolutionary abundance reflex to modern addiction and functional inversion of the human brain hierarchy
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deleteGuerrero, Gaston Lenin Nole
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Histaminergic modulation as a hidden determinant of psychopharmacological clinical response
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deleteAl Alaili, Mohammed Khaled
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The iNOS paradox: how high NO flux suppresses inflammation through S-nitrosylation and cGMP signaling under redox-buffered conditions
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delete2026-05-01
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deleteLee, Sang-Seop
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Somatic hypermutation-Driven IgM diversity as a transient determinant of the follicular antigen landscape
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deleteKhalleefah, Ahmed
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Immunonitrosative role in nimesulide hepatotoxicity: The S100A8/A9/ RAGE/NF-κB/iNOS axis as a unifying hypothesis
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deletePrudencio, Rafael da Silva; de Sousa, Antonio Kleiton; da Costa, Ana Clara Coelho; Holanda, Danyela Maria Leal; Rodrigues, Vanderlene Oliveira; Oliveira, Adao Santiago de Sousa; Santos, Gabriel da Cruz; Muniz, Lara da Cunha; Magalhaes, Diva de Aguiar; Sousa, Joao Janilson da Silva; Barbosa, Andre Luiz dos Reis
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A conceptual framework for stress-assisted degradation in facial skin aging with environmental modulation
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deleteKim, Min Tae
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A neurophysiological model of patellofemoral pain: The role of cortical and spinal mechanisms - A theoretical model
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deleteYoo, Takhyun; Burland, Julie P.; Koirala, Nabin; Lepley, Adam S.; Glaviano, Neal R.
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The application of red laser associated with methylene blue promotes better healing outcomes in nipple fissures: a hypothesis study
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deletede Sousa e Sousa, Antonia Clarice; Saraiva, Ana Carolinny Cruz; de Araujo, Maria Aparecida Jacome; Gallo, Rubneide Barreto Silva; Lenzi, Juliana; Gouveia, Guilherme Pertinni de Morais
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Differential biological actions of polydeoxyribonucleotide and hyperosmolar dextrose in temporomandibular joint osteoarthritis: a synovitis-driven, stage-specific injection hypothesis
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deleteChoi, Wan-Su; Shin, Jung-Woog; Ok, Soo-Min
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Premaxilla and incisive papilla as a nasopalatine sensory gateway: A developmental hypothesis linking trigeminal V2 afference to brainstem state calibration, oral posture, breathing mode, and childhood neurobehavior
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deleteWinter, Bjorn U.
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Radio-cofactor hypothesis based on Magnesium-28: An atomic switch for enzymatic metabolic control in cancer and RNA virus diseases
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deleteLuyen, Tran Van
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Hypothesis: An immuno-biomechanical model of anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis
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deleteOakley, Stephen Philip
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