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Optimizing Clinical Study Designs for CAR-T Cell Therapy: Development of an Efficient Sampling Strategy Through Optimal Experimental Design
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delete2026-07-07
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deleteFenja Klima; Anna M. Mc Laughlin; Robin Michelet; Wilhelm Huisinga; Katy Haussmann; Annette Künkele; Andrew C. Hooker; Charlotte Kloft
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Integrated Population Pharmacokinetic Analysis of Intravitreal Aflibercept Drug Products
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delete2026-06-30
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deleteSébastien Bihorel; Joannellyn Chiu; Jason Chittenden; Thomas Eissing; Kenneth C. Turner; Joachim Höchel; Torsten Zimmermann; Zhongqing Will He; John D. Davis; A. Thomas DiCioccio; Lutz O. Harnisch
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Development and Use of a Population Pharmacokinetic Model for Characterizing the Pharmacokinetics of Vonoprazan in Pediatric Patients
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delete2026-06-30
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deleteDarcy J. Mulford; Axel Facius; Galen Witt; Colin W. Howden; Thomas Wagner; Eckhard Leifke; Carmelo Scarpignato
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Butorphanol Pharmacokinetics Across Species: Meta-Analysis Integrating Allometric Scaling and Minimal Physiologically Based Pharmacokinetic Modeling
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delete2026-06-27
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deleteAhmed M. Saeed; William J. Jusko
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Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework
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delete2026-06-25
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deleteMoriah Pellowe; Ilse Dubbelboer; Erik Sjögren
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Population Pharmacokinetics and Pharmacodynamics of Paracetamol in Malaysian Patients With Plasmodium knowlesi Malaria
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-22
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deleteThanaporn Wattanakul; Daniel J. Cooper; Katherine Plewes; Matthew J. Grigg; Giri S. Rajahram; Timothy William; Arjen M. Dondorp; Michael D. Edstein; Geoffrey W. Birrell; Nicholas M. Anstey; Richard M. Hoglund; Bridget E. Barber; Joel Tarning
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Development of an Agent-Based Model to Investigate Durability of Factor IX Activity in Hemophilia B Patients Treated With Etranacogene Dezaparvovec
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-20
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deleteYuezhe Li; Partha Nandy; Eric Jordie; Timothy Knab; Karsten Peppel; Daniel C. Kirouac; A. Katharina Wilkins; Silpa Nuthalapati
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Polymyxin B Intravenous Administration Strategy Guided by Minimum Inhibitory Concentration in Critically Ill Patients With Pulmonary Infection: Insights From PBPK Modeling
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-19
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deleteShengnan Zhang; Nan Yang; Ruwei Yang; Yuanfang Qin; Tingting Wu; Cuifang Wu; Yueliang Xie; Jingjing Liu; Chun Liu; Qi Pei
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The Empirical Bayes Variational Autoencoder—A Neural ODE Approach for Population Modeling in Pharmacology
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-17
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deleteMarcus Baaz; Anders Sjöberg; Mats Jirstrand
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PK and PK/PD Modeling of Bcl2 Inhibitor S65487 in Patients With AML and Investigation of Nonlinearity With Microdosing
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-17
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deleteChloé Burlot; François Riglet; Mathilde Romagnoli; Ariane Leconte; Audrey Delmas; Antonin Schmitt; Sylvain Fouliard
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PMX-CovEval: A Framework Including a Simulated Pharmacokinetic Database for Covariate Model Building Methods Benchmarking
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-17
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deleteMélanie Karlsen; Jérôme Azé; Sandra Bringay; Pascal Poncelet; David Fabre; David Marchionni; Elisa A. M. Calvier
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Cellular Heterogeneity in Drug Uptake Amplifies Pharmacodynamic Variability: A Stochastic PK-PD Analysis
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-15
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deleteNhung Hong-Thi Duong; Tuan Ngoc Do; Tien Tran-Nam Nguyen; Khanh Quoc Phan; Lap Thi Nguyen
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AI-Powered Lesion-Level Tumor Growth Inhibition Modeling Improves Model Stability and Prognostic Association With PFS
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-13
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deleteAlan Liu; Chong Duan; Kevin Maresca; Yazdi K. Pithavala; Jen-Tang Lu; Cathy Cen Guo; Jennifer E. Hibma
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Physiologically Based Pharmacokinetic Model to Predict Drug–Drug Interactions With the Antibody–Drug Conjugate Trastuzumab Deruxtecan
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-09
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deleteAkiko Watanabe; Katherine L. Gill; Kuan-Fu Chen; Hannah M. Jones; Mailys De Sousa Mendes; Iain Gardner; Masakatsu Kotsuma
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Evaluation of the Current ATTR-CM Treatment Landscape via a Mathematical Model of TTR Dissociation and Amyloid Formation
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-08
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deleteStevan Methven Jeknić; Travis A. Ahn-Horst; Alan X. Ji; Jin Hyun Ju; Morgan Paull; Sun-Gou Ji; Uma Sinha
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Modeling Peak Expiratory Flow in Patients With Asthma and Quantifying Treatment Effects Using a Mixed-Effects Hidden Markov Model
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-06
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deleteLudvig Jakobsson; Marcus Baaz; Jacob Leander; Philip Gerlee; Mats Jirstrand
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Simulation Framework to Investigate Efficacy and Ocular Safety of Belantamab Mafodotin Combinations in Relapsed/Refractory Multiple Myeloma
deletecpt: pharmacometrics & systems pharmacology
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delete2026-06-04
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deleteFernando Carreño; Martijn van Noort; Adekemi Taylor; Stefan Zeiser; Theodoros Papathanasiou; Teun M. Post; Yi Ting (Kayla) Lien; Yu Liu Ho; Geraldine Ferron-Brady
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Pharmacokinetic Model Based Sensitivity Analysis to Lower Recruitment Burden for Young Children Requiring Intravenous Immunoglobulin G Replacement
deletecpt: pharmacometrics & systems pharmacology
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delete2026-05-31
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deleteTodd Dumas; Shahram Mehr; Rebecca Avila; Amy Doman; Kaitlin Kestenberg; Isaac Melamed
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External Evaluation of Population Pharmacokinetic Models of Cabotegravir, During Its Oral and Intramuscular Administration in HIV-Infected Patients
deletecpt: pharmacometrics & systems pharmacology
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delete2026-05-22
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deleteQuentin Renou; Nadège Néant; Alexandre Destere; Jennifer Lagoutte-Renosi; Matthieu Grégoire; François Parant; Sébastien Lalanne; Florian Lemaitre; Peggy Gandia; Nicolas Venisse; Stéphane Bouchet; Minh P. Lê; Patrice Muret; Gilles Peytavin; Caroline Solas; Sihem Benaboud; the CARLA Study Group
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Physiologically Based Pharmacokinetic Modeling of Elexacaftor/Tezacaftor/Ivacaftor in Infants With Cystic Fibrosis
deletecpt: pharmacometrics & systems pharmacology
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delete2026-05-22
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deleteNgoc Hoa Truong; Sihem Benaboud; Naïm Bouazza; Eric Deneuville; Anne Mornand; Philippe Reix; Mélanie Ribault; Pierre-Régis Burgel; Léo Froelicher-Bournaud; Steeve Rouillon; Mohammed Rohi Sanoufi; Gabrielle Lui; Saïk Urien; Jean-Marc Tréluyer; Isabelle Sermet-Gaudelus; Frantz Foissac; Modul-CF study group
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