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Drug Metabolism and Disposition cover

Drug Metabolism and Disposition

IF4
Papers412
Citations12011
Journal Papers 398
Publication Date
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A Previously Undetected Major Circulating Metabolite of Trazpiroben Revealed by Human Radiolabeled Absorption, Distribution, Metabolism, and Excretion Study
deleteDrug Metabolism and Disposition
IF4
delete2026-09-29
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deleteSean Xiaochun Zhu; Mitsuhiro Nishihara; Diane Ramsden; Shailly Mehrotra; Kouta Matsumiya; Suresh K. Balani
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Monocarboxylate transporter 6 mediates sex-dependent cisplatin ototoxicity via metabolite uptake
deleteDrug Metabolism and Disposition
IF4
delete2026-09-29
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PREAI
deleteArthur Germakovski; Mengxiao Ye; Vivian Xu; Guang-Di Chen; Li Li; Richard Pasternack; Jason Dey; Lara Karzoun; Jeanine Day; Christian Lopez; Emma R. Evereth; Benjamin D. Kaczynski; Wei Sun; Mark Parker; Bo Hua Hu; Jason A. Sprowl
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EVALUATION OF DEUTERIUM ISOTOPE EFFECTS ON THE METABOLISM OF TEN DRUGS ACROSS MULTIPLE HUMAN CYTOCHROME P450 ENZYMES: CONSIDERATIONS FOR DRUG DESIGN
deleteDrug Metabolism and Disposition
IF4
delete2026-09-29
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PREAI
deleteR. Scott Obach; Matthew A. Cerny
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Impact of Nonspecific Binding to Membrane Vesicles on Unbound IC50 Estimation for P-glycoprotein and BCRP Inhibitors and Implications for DDI Risk Assessment
deleteDrug Metabolism and Disposition
IF4
delete2026-09-17
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PREAI
deleteRenjie Zhan; Richard Moulton; Scott Tallman; Shelby Hullett; Sangwoo Ryu; Michael Mohutsky; Maria Posada; Bridget Morse; Chester Costales
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Functional Characterization of Rare DPYD Variants Identified in 8,380 Japanese Individuals: Implications for 5-Fluorouracil Metabolism
deleteDrug Metabolism and Disposition
IF4
delete2026-09-17
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PREAI
deleteKento Terauchi; Eiji Hishinuma; Akiko Ueda; Shota Nishihara; Sakae Saito; Shu Tadaka; Kengo Kinoshita; Masamitsu Maekawa; Nariyasu Mano; Yuu Miyauchi; Masahiro Hiratsuka
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Biotransformation and Disposition of Inavolisib, a Selective PI3Kɑ Inhibitor, in Humans
deleteDrug Metabolism and Disposition
IF4
delete2026-09-17
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PREAI
deleteSungjoon Cho; Sravanthi Cheeti; Ryan Johnson; Jing Wang; Nicky Hwang; Laurent Salphati; S. Cyrus Khojasteh; Shuguang Ma; Donglu Zhang
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When microbial drug metabolism becomes a drug disposition variable
deleteDrug Metabolism and Disposition
IF4
delete2026-09-11
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PREAI
deleteRebecca Lewandowski
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A SYSTEMATIC SURVEY OF COMPUTATIONAL DRUG–DRUG INTERACTION PREDICTION: PROBLEM FORMULATIONS, DATA CHALLENGES, AND SCALABLE ARCHITECTURES
deleteDrug Metabolism and Disposition
IF4
delete2026-09-08
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PREAI
deleteCanan KOÇ; Fatih ÖZYURT
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Repaglinide metabolism by human hepatocytes reveals CYP2C8 dominance and misassignment of CYP3A4 by liver subcellular fractions and recombinant enzymes
deleteDrug Metabolism and Disposition
IF4
delete2026-09-08
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PREAI
deleteTashinga E. Bapiro
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Submicellar aggregates of deoxycholate and glycodeoxycholate suppress in vitro CYP3A oxidation via membrane perturbation
deleteDrug Metabolism and Disposition
IF4
delete2026-09-08
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PREAI
deleteCuitong Wang; Qi Chen; Ke Lan
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Liposomal encapsulation redirects the in vivo disposition of paclitaxel: a comparative pharmacokinetic, tissue distribution, and excretion study in rats
deleteDrug Metabolism and Disposition
IF4
delete2026-09-08
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PREAI
deleteGuolei Zhang; Ning Zhang; Yu Miao; Yidan Zhang; Lei Yin; Meiyun Shi
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Soluble epoxide hydrolase research, international collaboration, and translational capacity in Brazil: the scientific legacy of Bruce D. Hammock
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IF4
delete2026-09-08
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PREAI
deleteWellington Francisco Rodrigues; Carlos Antônio Trindade-da-Silva; Camila Botelho Miguel; Aristóteles Góes-Neto; Christophe Morisseau; Carlos Ueira-Vieira
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Systematic Evaluation of Five Classical Mechanistic Methods for Tissue-Plasma Partition Coefficients Across Diverse Tissues and Compound Classes
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IF4
delete2026-09-08
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PREAI
deleteJia Geng; Ammara Ayub; Feifan Xie
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Redefining the Michaelis-Menten Kinetics Mechanistic Basis and Derivation in Drug Metabolism, Pharmacology, Biochemistry, Chemistry, and Pharmacokinetics
deleteDrug Metabolism and Disposition
IF4
delete2026-09-08
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deleteLeslie Z. Benet; Jasleen K. Sodhi
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Interindividual Variability in Hepatic Hydrolytic Enzymes: Effects of Age, Sex and Race on the Abundance of Drug-Metabolizing Hydrolases
deleteDrug Metabolism and Disposition
IF4
delete2026-09-08
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deleteDilip Kumar Singh; Deepak Ahire; Scott Heyward; Robert S. Jones; S. Cyrus Khojasteh; Ryota Kikuchi; Priyanka Kulkarni; Bin Ma; Bernard P. Murray; Bill J. Smith; David M. Stresser; Mitchell E. Taub; Ting Wang; Bhagwat Prasad
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Proteomic profiling of drug and nutrient transporter expression by small intestinal region in neonates, pediatrics, and adults
deleteDrug Metabolism and Disposition
IF4
delete2026-09-04
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deleteVicky L. Sun; Kai Wang; Joanne Wang; Jashvant D. Unadkat; Edward J. Kelly; Samuel L.M. Arnold
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Idelalisib 8-oxidation as an enzyme-selective catalytic marker of human aldehyde oxidase in HepG2 cells: Application to the investigation of enzyme inactivation
deleteDrug Metabolism and Disposition
IF4
delete2026-09-01
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deleteNicholas Kai Ming Ng; Sian Wen Chan; Andres Kai Zhi Lim; Min Hao Eng; Vijaya Saradhi Mettu; Aik Jiang Lau
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Effects of simulated exogenous and endogenous lipid microenvironments on cannabidiol disposition and cytochrome P450 2C19-mediated drug interactions: New mechanistic insights
deleteDrug Metabolism and Disposition
IF4
delete2026-09-01
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PREAI
deleteNguyen, Aiden-Hung P.; Rotich, Fridah C.; Cech, Nadja B.; Paine, Mary F.
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The absorption, distribution, metabolism, excretion, and pharmacokinetic properties of the pan-rapidly accelerated fibrosarcoma (RAF) inhibitor naporafenib in healthy subjects: An absolute bioavailability and mass balance study
deleteDrug Metabolism and Disposition
IF4
delete2026-09-01
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PREAI
deleteLam, Justine L.; Shen, Zhongzhou; Vaz, Alfin; Picard, Roxana; Ching, Ai Ling; Fujimori, Shinji; Chen, Xiaoying; Xuan, Dawei
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Chromobox 4 interacts with pregnane X receptor to repress CYP3A4 expression through polycomb repressive complex 1/2-mediated epigenetic regulation
deleteDrug Metabolism and Disposition
IF4
delete2026-09-01
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PREAI
deleteKamiyoshihara, Ibuki; Nakano, Masataka; Yokoseki, Itsuki; Tomii, Mei; Higuchi, Yuichiro; Uehara, Shotaro; Yoneda, Nao; Suemizu, Hiroshi; Fukami, Tatsuki; Nakajima, Miki
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