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Drug Metabolism and Disposition cover

Drug Metabolism and Disposition

IF4
Papers367
Citations12011
Journal Papers 353
Publication Date
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Virtual special section: Gut microbiota in drug metabolism
deleteDrug Metabolism and Disposition
IF4
delete2026-07-09
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PREAI
deleteHyunyoung Jeong
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PSMD2 mediates the degradation of CYP1A2 and promotes the progression of metabolic dysfunction-associated steatohepatitis
deleteDrug Metabolism and Disposition
IF4
delete2026-07-09
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PREAI
deleteMin Liu; Tianhao Liu; Dongsheng Liu; Jiaying He; Qin Shao; Jiye Aa; Guangji Wang; Yuan Xie
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Modeling cortisol and cortisone binding to corticosteroid binding globulin and albumin based on clinical protein binding data
deleteDrug Metabolism and Disposition
IF4
delete2026-07-09
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deleteAurora K. Authement; Abhinav Nath; Katya B. Rubinow; John K. Amory; Nina Isoherranen
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A comprehensive investigation into the effect of bisphenol-A on the expression of drug-metabolising enzymes: consequences for endogenous metabolites and xenobiotic pharmacokinetics.
deleteDrug Metabolism and Disposition
IF4
delete2026-07-07
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PREAI
deleteAnanthu MR; Kannan Shajkumar; Subhasree Biswal; Aiswarya Suresh; Shrutika Milind Wankhade; Anandhu Kunnath Shaji; Swapnil Jayant Dengale
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A Three-Step Static Mechanistic Modelling Approach to Predicting Transporter- and Enzyme-Mediated Interaction Signals of Direct Oral Anticoagulants
deleteDrug Metabolism and Disposition
IF4
delete2026-07-06
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deleteMostafa ben Ahmed; Anne M. Filppula; Aleksi Tornio
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Microfluidic liver-chip to predict clinical drug-drug interaction net effects for precipitant drugs with dual CYP3A4 inhibition and induction potential
deleteDrug Metabolism and Disposition
IF4
delete2026-07-03
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PREAI
deleteLina Mettler; Justine Badée; Felix Huth; Christian Lohasz; Johanna Alm; Judith Streckfuss; Hilmar Schiller; Peter Loskill; Birk Poller; Julia Riede
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Spatial Metabolite Profiling Identifies Taurocholic Acid as a Protective Mediator in Hepatic Ischemia-Reperfusion Injury: A Mass Spectrometry Imaging and Pharmacological Study
deleteDrug Metabolism and Disposition
IF4
delete2026-07-03
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PREAI
deleteChuang Du; Chu-Ting Xu; Qi Zhang; Lei Chen; Shan-Shan Zhao; Yi-Zhe Fan; Guang-Bo Ge; Zhan-You Wang; Hui-Xin Liu
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Physiologically based pharmacokinetic framework for predicting CYP3A4-mediated drug–drug interactions of quetiapine with ketoconazole and carbamazepine
deleteDrug Metabolism and Disposition
IF4
delete2026-07-01
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PREAI
deleteJi-Hun Jang; Seung-Hyun Jeong
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Generation and characterization of a serum albumin-humanized mouse model and its utility for detection of albumin adduct formation in vivo
deleteDrug Metabolism and Disposition
IF4
delete2026-06-30
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deleteXiangmeng Wu; Weiguo Han; Lei Yin; Weizhu Yang; Jonathan Sheng; John Han; Robert J. Turesky; Laura S. Van Winkle; Qing-Yu Zhang; Xinxin Ding
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PBPK modeling of the unusual kinetics of ketoconazole due to nonlinear liver binding and metabolism in rats
deleteDrug Metabolism and Disposition
IF4
delete2026-06-30
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PREAI
deleteHee Eun Kang; Keumhan Noh; Jianfeng Huang; Liangliang Xu; Yanfen Teng; Lilly Xu; K. Sandy Pang
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PI3K-AKT-P-gp/Mrp2 signaling pathway drives the accelerated hepatic clearance of encapsulated docetaxel of PEGylated liposomes
deleteDrug Metabolism and Disposition
IF4
delete2026-06-29
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deleteJianquan Pan; Huiya Deng; Cheng Zhang; Hongwei Zhu; Yunna Chen; Sheng Zhang; Lei Wang; Fengling Wang; Weidong Chen
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NOLC1 enhances the induction of CYP3A4 by promoting nuclear translocation of pregnane X receptor
deleteDrug Metabolism and Disposition
IF4
delete2026-06-29
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PREAI
deleteKyoka Nagaoka; Masataka Nakano; Kiamu Kurosawa; Yuichiro Higuchi; Shotaro Uehara; Nao Yoneda; Hiroshi Suemizu; Tatsuki Fukami; Miki Nakajima
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Role of CYP3A5 and CYP3A4 in the metabolism and toxicity of 10-hydroxyl mesaconitine, a new potential toxicity marker of Radix Aconiti Lateralis Preparata (Fuzi), in vitro and in vivo
deleteDrug Metabolism and Disposition
IF4
delete2026-06-29
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deleteYu Fu; Yu Cai; Fangyuan Li; Tongyang Ma; Caiyan Wang; Rong Zhang; Zhongqiu Liu; Dongyan Bai; Qi Liang; Lijun Zhu
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CYP1A2 and ADH1C contribute to abacavir aldehyde intermediate formation in the human liver
deleteDrug Metabolism and Disposition
IF4
delete2026-06-22
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deleteRei Sato; Masataka Nakano; Yuichiro Higuchi; Shotaro Uehara; Nao Yoneda; Hiroshi Suemizu; Miki Nakajima; Tatsuki Fukami
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Mechanistically resolved prediction of compound hepatotoxicity using primary human liver spheroids – application to recent real-world cases
deleteDrug Metabolism and Disposition
IF4
delete2026-06-22
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deleteYufeng Li; Hongda Sheng; Tingting Zhou; Chen Xing; Miriam Kukasch; Siyuan Shao; Sonia Youhanna; Sabine U. Vorrink; Yingxin Liang; Anne T. Nies; Julia Dressler; Charlotte Kölz; Jinhye Ryu; Nayere Taebnia; Dominik Jacob; Caroline Hauser; Carl Petersson; Kathrin Klein; Oliver Burk; Boxu Shi
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AQUA-ADME: A Protein Standard Addition Framework for Absolute Quantification of Drug Metabolizing Enzymes
deleteDrug Metabolism and Disposition
IF4
delete2026-06-20
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PREAI
deleteXiaofeng Wu; Sam Zhang; R. Scott Obach; Qianying Yuan; Kimberly Lapham; Yuanyuan Shi; Lloyd Wei Tat Tang
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CYP3A-mediated metabolic activation of fibleucin from Tinospora sagittata initiates liver injury in mice
deleteDrug Metabolism and Disposition
IF4
delete2026-06-17
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deleteJie Dai; Yufen Liao; Xueqian Cheng; Qing Zhang; Tingmin Ye; Dandan Yang; Chunlei Zhang; Ying Peng; Weiwei Li; Jiang Zheng
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High-level expression of full-length human CYP2E1 in E. coli: Comparison of full-length human CYP2E1 to truncated counterpart shows enhanced association with redox partners
deleteDrug Metabolism and Disposition
IF4
delete2026-06-15
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PREAI
deleteYudong Sun; Praveen Amunugama; Yoichi Osawa; Haoming Zhang
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Investigation of biomarkers for azole antifungal-induced liver injury using primary human hepatocyte spheroids
deleteDrug Metabolism and Disposition
IF4
delete2026-06-15
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deleteMasaki Kumondai; Ayaka Yagi; Masahiro Watanabe; Yanlin Lyu; Ryosuke Segawa; Mayumi Sato; Ryo Tadakuma; Kenji Inoue; Hideki Watanabe; Masahiro Takeda; Yoshiteru Ohshima; Masamitsu Maekawa; Nariyasu Mano
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Absorption, metabolism, and excretion of single-dose oral [14C]camizestrant in healthy human female participants
deleteDrug Metabolism and Disposition
IF4
delete2026-06-11
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deleteAndy Sykes; Zhoupeng Zhang; Jana Skeete; Pradeep Sharma; Stephen Wilkinson; Ryan Bragg; Sasha McClain; Malin Granfors; Isobel Leddin; Christopher Bailey; Bistra Kirova; Nand Singh; Karthick Vishwanathan; Niresh Hariparsad
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