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Signal Transduction and Targeted Therapy

IF52.7
Papers1174
Citations51218
Journal Papers 1054
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Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study
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IF52.7
delete2026-08-13
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deleteJia Yu; Anwen Xiong; Qiming Wang; Jianhua Chen; Hongrui Niu; Chengzhi Zhou; Panwen Tian; Wu Zhuang; Jie Li; Jing Wang; Junguo Lu; Kangsheng Gu; Jinsheng Shi; Jun Guo; Yonghui Di; Dongqing Lv; Debin Sun; Liming Cao; Zhixiong Yang; Jingxun Wu; Liyun Miao; Yueyin Pan; Chong Li; Xiaohong Wu; Jie Yin; Xiang Wang; Meili Sun; Miao He; Shundong Cang; Haohui Fang; Ping Chen; Min Zhang; Xinmei Yang; Hui Zhao; Jian Feng; Xuezhen Ma; Sheng Hu; Jian Lu; Xin Zhao; Zhixiang Zhuang; Yilan Sun; Xu Sun; Bing Yu; Chaonan Zhu; Jianghua Chen; June Xu; Kai Wang; Caicun Zhou
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Translational insights and clinical challenges of targeting cancer stem cells
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delete2026-08-13
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deleteMehreen Ahmed; Amr Al-Haidari; Shruti Agarwal; Jianmin Sun; Emma U. Hammarlund; Lars Rönnstrand; Kenneth J. Pienta; Özge Tatli; Julhash U. Kazi
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Innate immunity: current understandings and future perspectives
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IF52.7
delete2026-08-12
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deleteChaoyu Zou; Teng Ma; Jing Li; Xikun Zhou
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Alzheimer’s disease: erasing the peptidyl-arginine deiminase 2 (PAD2) stamp to restore microglial defense
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delete2026-08-12
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deleteXiya Shen; Shengya Wang; Weihong Song
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From probe to prodrug: immunoproteasome activity as a trigger for disease-selective therapeutics
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delete2026-08-12
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deleteCody A. Loy; Yijun Gu; Samuel C. Kim; Mariam V. Mohagheghi; Noah B. Trask; Marina Suarez-Pizarro; Lisa E. Wagar; Claudia A. Benavente; Darci J. Trader
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C-MET tyrosine kinase receptor: mechanisms, clinical applications and future perspectives in cancer therapy
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IF52.7
delete2026-08-11
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deleteChenjing Zhu; Yue Li; Hanzi Xu; Li Sun; Yuancheng Wei; Chengxian Ma; Qingjuan Chen; Xia He
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Hypoxia increases the activity of oncolytic adenoviruses through HIF-2α-stimulated E1A expression
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IF52.7
delete2026-08-11
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deleteEgon J. Jacobus; Véronique N. Lafleur; Kerry D. Fisher; David R. Mole; Leonard W. Seymour
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CAR T cell therapy beyond cancer: current status, challenges and future prospects
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deleteSaurabh Upadhyay; Sungwoo Cho; Kirti Upmanyu; Moustafa T. Gabr
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Temperature-sensitive liquid embolic agent transarterial chemoembolization versus drug-eluting bead transarterial chemoembolization for BCLC Stage B/C hepatocellular carcinoma: a multicenter real-world study and spatial transcriptomics profiling (CHANCE 2515)
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IF52.7
delete2026-08-11
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deleteQingyun Xie; Ying Yang; Sinan Xie; Xiaojuan Yang; Fengwei Gao; Weili Qi; Hu Liu; Yuanjun Liu; Jiran Deng; Xianguo Liu; Yi Zhou; Xin Zhao; Kangyi Jiang; Tianyang Mao; Xiuyong Liao; Ruihong Dai; Yinghao Lyu; Yunshi Cai; Kunlin Xie; Hong Wu; Tian Lan; Chang Liu
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Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer
deleteSignal Transduction and Targeted Therapy
IF52.7
delete2026-08-10
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deleteBo Lan; Faliang Xu; Tao Sun; Fuming Qiu; Yongsheng Wang; Shouman Wang; Wei Li; Yahua Zhong; Xinhong Wu; Quchang Ouyang; Ke Wang; Xiaolan Mi; Rui Liu; Binghe Xu
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Mechanisms and therapeutic strategies of asthma: from bench to bedside
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IF52.7
delete2026-08-10
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deleteCong Xie; Ying Wei; Chang Su; Maimaititusun Yalikun; Yiwei Chu; Hang Yu; Meiling Jin; Weifang Xu; Jiangtao Lin; Jingcheng Dong
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Calr-mediated calcium buffering: a molecular barrier to in vivo cardiac reprogramming
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IF52.7
delete2026-08-07
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deleteJohnny Kim; Hans R. Schöler; Kee-Pyo Kim
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Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer
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IF52.7
delete2026-08-07
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deleteSi-Jie Chen; Shi-Wei Yue; Yun-Pu Zhang; Hui-Fang Liang; Hai-Xin Wu; Xiao-Ping Chen; Bi-Xiang Zhang; Wei Zhang
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RNA methyltransferase 3 drives pancreatic acinar cell carcinoma growth and is a therapeutic target
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IF52.7
delete2026-08-06
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deleteShotaro Tatekawa; Tomoaki Hara; Sikun Meng; Tetsuya Sato; Takahiro Arai; Keisuke Tamari; Yasuko Arao; Yoshiko Tsuji; Masamitsu Konno; Ken Ofusa; Koji Kitamura; Sarah Rennie; Motoharu Inui; Daisuke Taguchi; Hirofumi Akita; Daisuke Motooka; Yoshiki Murakumo; Hidenori Inohara; Yuichiro Doki; Hidetoshi Eguchi; Kazuhiko Ogawa; Hideshi Ishii
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Novel highly selective ROCK2 inhibitor (TDI01) for the treatment of chronic graft-versus-host disease: a multicenter, open-label phase Ib/II study
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IF52.7
delete2026-08-06
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deleteXiaodong Mo; Xuejun Zhang; Rong Guo; Erlie Jiang; Jiejing Qian; Xiaoyu Zhu; Jia Wei; Shunqing Wang; Zhongming Zhang; Zhuogang Liu; Yuxian Huang; Zhiguo Wang; Xiaoyuan Dong; Hai Yi; Ying Li; Dong Chai; Weilan Wang; Weiting Zhong; Guoping Dong; Xiaojun Huang
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Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets
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IF52.7
delete2026-08-05
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deleteYufeng Lu; Di Shao; Yi Xiao; Yi-Zhou Jiang; Zhi-Ming Shao
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RAF1 extrachromosomal DNA amplification confers acquired erlotinib resistance in a non-small cell lung cancer cell model
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delete2026-08-05
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deleteSujin Kim; Boyoon Kim; Ahjin Lim; Hoon Kim; Jeonghee Cho
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Peptide-targeted cubosome and hexosome nanoassemblies mitigate mitochondrial dysfunction in a MitoPark model
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IF52.7
delete2026-08-04
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deleteThelma Akanchise; Fucen Luo; Borislav Angelov; Yuru Deng; Takehiko Fujino; Angelina Angelova
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β-cell-targeted RNA activation of vascular endothelial growth factor-A improves islet transplantation
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deleteDimitri Van Simaeys; Per-Olof Berggren
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A molecular glue induces aberrant STING oligomerization and inhibits autoinflammatory diseases
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delete2026-08-04
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deleteZi-Wen Feng; Ting Zeng; Qing Shu; Xiao-Zhong Li; Hai-Guo Yu; Wei Dai; Xue-Chun Liu; Xin-Jian Tian; Feng Xu; Hui Li; Ye-Ling Zhou; Shi-Duo Zhang; Lin-Lin Li; Nan-Nan Chen; Xiao-Yan Liu; Zi-Wen Liu; Jie Yin; Hong-Tao Shen; Chun-Chen Che; Mei-Rong Chen; Dan-Dan Wang; Ling-Yun Sun; Yi-Bei Xiao; Qi-Dong You; Xiao-Li Xu
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