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Journal of Medicinal Chemistry cover

Journal of Medicinal Chemistry

IF6.8
Papers26523
Citations94469
Journal Papers 26155
Publication Date
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Cisproplatin: A Redox-Activatable Cisplatin-Probenecid Pt(IV) Conjugate with Broad NCI-60 Potency that Decouples Antitumor Efficacy from Dose-Limiting Toxicity and Suppresses CIPN
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-07-14
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deleteKajol; Avinash Choudhury; Arka Banerjee; Prakash Shukla; Subhra Jyoti Panda; Rakesh Kumar Pathak
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Beyond α-GalCer: Medicinal Chemistry Insights Driving Structural Evolution of CD1d Ligands
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IF6.8
delete2026-06-13
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deleteEmiliano Paradiso; Žiga Jakopin
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Design; Synthesis; and Evaluation of Bibenzyl Analogues against Hepatocellular Carcinoma by Targeting Pyruvate Carboxylase
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-12
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deleteZeen Qiao; Lingyu Li; Yuwen Sheng; Jinlian Yang; Jialing Yu; Fan Wu; Minghui Ji; Ruiying Xi; Linhan Yang; Guolin Zhang; Xiaoxia Lu; Xiaofeng Ma; Fei Wang
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Targeting the Energy-Coupling Factor Transporters: A Novel Antibiotic Drug Target in Streptococcus pneumoniae
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-12
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deleteEleonora Diamanti; Amelieke J.H. Cremers; Yue Li; Ioulia Exapicheidou; Carole Baumann; Paddy Gibson; Atanaz Shams; Louise Martin; Rouven Becker; Inda Setyawati; Lucie Zeimetz; Jörg Haupenthal; Matthias Witschel; Dirk J. Slotboom; Jennifer Herrmann; Katharina Rox; Mostafa M. Hamed; Jan-Willem Veening; Anna K. H. Hirsch
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Self-Assembling Amphiphilic PROTACs: A Chemical Strategy for Improved EGFR-Targeted Protein Degradation
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-12
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deleteJunhui Ma; Lei Fang; Yu Wu; Hui Jiao; Guangya Xiang; Xiang Ma
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Confusion Without Measure: Units; Assumptions; and Best Practices in Reporting Preclinical ADME/PK Data
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-11
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deleteMatthew C. Robinson
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Antenna Tuning in Photoredox Nitric Oxide Releasers for Potent Photovasodilation
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-11
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deleteDaisuke Saitoh; Sae Kitamura; Naoya Ieda; Kyoya Oyama; Yuhei Ohta; Yuji Hotta; Masato Kobayashi; Mei Harada; Mikako Ogawa; Mitsuyasu Kawaguchi; Kazunori Kimura; Tetsuya Taketsugu; Hidehiko Nakagawa
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Design; Synthesis; and Evaluation of Antitumor Activity of Novel Phenylahistin Derivatives with Double F-Substitution via Dual Inhibition of Microtubule and P53/BCL-2/BAX Signaling Pathways
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-11
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deleteGang Wang; Shihao Wang; Zhongpeng Ding
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First Structure–Activity-Relationship Study of Potent G2A Antagonists
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-11
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deleteVictor Hernandez-Olmos; Jan Heering; Felix F. Lillich; Beatrice Marinescu; Sheila Nevermann; Johanna H. M. Ehrler; Dmytro S. Radchenko; Yurii S. Moroz; Astrid Kaiser; Andreas Krämer; Stefan Knapp; Manfred Schubert-Zsilavecz; Mohamad Wessam Alnouri; Stefan Offermanns; Dieter Steinhilber; Marco Sisignano; Ewgenij Proschak
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Mixed Lineage Kinase Suppression in Triple-Negative Breast Cancer: Identification of a Dual Inhibitor Targeting MLK3 and NAMPT
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-10
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deleteGanga Reddy Velma; Sandeep Kumar; Piush Srivastava; Sweta Misra; Rakesh Sathish Nair; Soumya Reddy Musku; Martha Ackerman-Berrier; Sunil Kumar Singh; Harsh Vyas; Erick T. M. Alves; Basabi Rana; Rui Xiong; Laura Bloem; Ajay Rana; Gregory R. J. Thatcher
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Gold(I)-Loaded Nanomedicine for Liver Cancer: A Closed-Loop Strategy Integrating Ferritinophagy-Driven Ferroptosis and Immunotherapy
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-10
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deleteYejin Zhu; Yifei Li; Yuming Jiang; Zhiyue Fan; Wukun Liu
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Design; Synthesis; and Pharmacological Evaluation of cGAS/HDAC Dual Inhibitors for Treatment of Autoimmune Diseases
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-10
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deleteZihua Zhou; Mingjie Chen; Shuyue Lei; Meng Wang; Chunyong Ding; Zilan Song; Wei Tang; Ao Zhang
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Structure-Based Design and Optimization of Novel PHGDH Inhibitors for Overcoming Erlotinib-Resistant Lung Cancer
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-09
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deleteXingmei Wu; Shuai Tang; Yiyang Yan; Xinyu Cao; Yixin Cen; Xiaojing Lan; Yingjie Zhu; Da-Yu Shi; Guo-Qiang Lin; Ping Tian; Min Huang; Dingding Gao
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Dual SYK-HDAC Inhibitor Elicits Striking Efficacy against Acute Myeloid Leukemia: Rational Design; Synthesis; and Biological Evaluation
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-09
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deleteAnshul Mishra; Wen-Bin Yang; Tsu-Shao Liu; Amandeep Thakur; Ajmer Singh Grewal; Jacek Marczyk; Giovanni Stelitano; Ram Sharma; Mandeep Rana; Gurpreet Singh; Santosh Kumar Guru; Goutam Rath; Saurabh Chawla; Jing Ping Liou; Chun Hsu Pan; Kunal Nepali
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Development and Preclinical Evaluation of 68Ga-Labeled B7-H3-Specific Bicyclic Peptides as Immuno-PET Tracers for Oncology
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-09
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deleteFengsheng Zhang; Jindian Li; Dongliang Wang; Xuwei Liu; Xiaoyu Pan; Simin He; Jianping Zhang; Hao Shen; Shaoli Song
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Drug Delivery Strategy Exploiting Amino Acid Prodrugs: Improving Oral Bioavailability and Overcoming Nonlinear Pharmacokinetic Challenges Following Dose Escalation of a CK2 Inhibitor with Poor Solubility
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-08
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deleteMurugaiah A. M. Subbaiah; Thangeswaran Ramar; Mathiazhagan Annadurai; Arunachalam Arumugam; Ramesh Samikannu; Kurt Zimmermann; Megha A. Thakur; Vinay K. Holenarsipur; Tarun Sharma; Sheelendra Singh; Shahe Mahammad; Mary T. Obermeier; Srinivas Kasibhatla; Natesan Murugesan; Sridhar Desikan; Sandhya Mandlekar; Gerry Everlof; Aberra Fura; Ashok V. Purandare
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PROTAC-Mediated DPP-4 Degradation: A New Solution for Type 2 Diabetes
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-08
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deleteWei Zeng; Liangzhu Feng
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Thiazole-Linked N-Hydroxypropanamide Derivatives: Selective HDAC6 Inhibitors with Therapeutic Potential for Neurodegenerative Diseases
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-04
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deleteGibeom Nam; Jun Min Jung; Seyun Yang; Da Eun Kim; Pulla Reddy Boggu; Cheolhee Kim; Eunae Kim; Chanhee Jo; Hyun-Mo Yang; Jihun Kim; Choon-Gon Jang; Sang J. Chung; Jae Hoon Sul; Dong-Gyu Jo; Young Hoon Jung; Hyun-Ju Park
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An Activator of Tailless’ Repressor Function Stimulates Anti-Neurodegenerative Gene Expression
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-03
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deleteEmily C. Hank; Romy Busch; Úrsula López-García; Till Kasch; Loris Knümann; Vasily Morozov; Georg Höfner; Julian A. Marschner; Daniel Merk
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Lead Optimization of TgCDPK1 Inhibitors for the Treatment of Toxoplasmosis
deleteJournal of Medicinal Chemistry
IF6.8
delete2026-06-03
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deleteMichael P. Mannino; Anusha Gokanapalle; Shrushti Patil; Anoopjit Singh Kooner; Chhuttan Lal Meena; Matthew Medcalf; Igi Vilza; Jennifer Barks; Yong Fu; Jing Xia; Jay C. Nix; Chris Nelson; Daved Fremont; Arun Dhillon; L. David Sibley; James W. Janetka
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