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Edward L. Huttlin

harvard medical school

44H-index
85Paper Count
1.7WCitation Count
Published Papers 55
Publication Date
An AI-enabled structural atlas decodes kinase specificity across the human proteome
err2026-07-29
err0
PREAI
errDavid R. Vanderwall; Edward L. Huttlin; Julian Mintseris; Tomer M. Yaron-Barir; Jared L. Johnson; Kevin D. Dong; Alex J. Bott; Yuchen He; Christina B. Schroeter; Geordon A. Frere; Mohamed Uduman; Harin Lee; Sean Landry; Sean A. Beausoleil; Joao A. Paulo; Lewis C. Cantley; Steven P. Gygi
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Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics
errNature
IF48.5
err2025-10-02
err0
errOAAI
errLeah V. Schaffer; Mengzhou Hu; Gege Qian; Kyung-Mee Moon; Abantika Pal; Neelesh Soni; Andrew P. Latham; Laura Pontano Vaites; Dorothy Tsai; Nicole M. Mattson; Katherine Licon; Robin Bachelder; Anthony Cesnik; Ishan Gaur; Trang Le; William Leineweber; Aji Palar; Ernst Pulido; Yue Qin; Xiaoyu Zhao; Christopher Churas; Joanna Lenkiewicz; Jing Chen; Keiichiro Ono; Dexter Pratt; Peter Zage; Ignacia Echeverria; Andrej Sali; J. Wade Harper; Steven P. Gygi; Leonard J. Foster; Edward L. Huttlin; Emma Lundberg; Trey Ideker
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Covariation MS uncovers a protein that controls cysteine catabolism
errNature
IF48.5
err2025-09-17
err0
errOAAI
errHaopeng Xiao; Martha Ordonez; Emma C. Fink; Taylor A. Covington; Hilina B. Woldemichael; Junyi Chen; Mika Sarkin Jain; Milan H. Rohatgi; Shelley M. Wei; Nils Burger; Muneeb A. Sharif; Julius Jan; Yaoyu Wang; Jonathan J. Petrocelli; Katherine Blackmore; Amanda L. Smythers; Bingsen Zhang; Matthew Gilbert; Hakyung Cheong; Sumeet A. Khetarpal; Arianne Smith; Dina Bogoslavski; Yu Lei; Laura Pontano Vaites; Fiona E. McAllister; Nick Van Bruggen; Katherine A. Donovan; Edward L. Huttlin; Evanna L. Mills; Eric S. Fischer; Edward T. Chouchani
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Altered Fibroblast Glutamine Metabolism Is Linked to the Severity of Cardiac Dysfunction in DCMA, a Mitochondrial Cardiomyopathy
err2025-03-03
err0
errOAAI
errKing, Melissa A.; Heger, Katherine C.; Drikic, Marija; Mandwal, Ayush; Khan, Aneal; Sinasac, David S.; Pittman, Keir; Huttlin, Edward L.; Greenway, Steven C.
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Profiling Proteins and Phosphorylation Sites During T Cell Activation Using an Integrated Thermal Shift Assay
err2024-07-01
err0
errOAAI
errGassaway, Brandon M.; Huttlin, Edward L.; Huntsman, Emily M.; Yaron-Barir, Tomer M.; Johnson, Jared L.; Kurmi, Kiran; Cantley, Lewis C.; Paulo, Joao A.; Ringel, Alison E.; Gygi, Steven P.; Haigis, Marcia C.
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A global multiscale map of protein assemblies from integration of protein interactions and images
err2024-03-22
err0
PREAI
errSchaffer, Leah V.; Hu, Mengzhou; Huttlin, Edward L.; Qian, Gege; Pal, Abantika; Soni, Neelesh; Latham, Andrew; Vaites, Laura Pontano; Trang Le; Qin, Yue; Churas, Christopher; Pratt, Dexter; Echeverria, Ignacia; Sali, Andrej; Harper, J. Wade; Gygi, Steven P.; Lundberg, Emma; Ideker, Trey
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A map of osteosarcoma cell architecture reveals convergence of pediatric cancer mutations on protein assemblies
err2024-03-22
err0
PREAI
errHu, Mengzhou; Schaffer, Leah V.; Huttlin, Edward L.; Qian, Gege; Latham, Andrew; Pal, Abantika; Vaites, Laura Pontano; Le, Trang; Qin, Yue; Churas, Christopher; Pratt, Dexter; Bachelder, Robin; Zage, Peter; Echeverria, Ignacia; Sali, Andrej; Harper, J. Wade; Gygi, Steven P.; Lundberg, Emma; Ideker, Trey
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Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection
err2023-12-08
err4
errOAAI
errAlbarnaz, Jonas D.; Kite, Joanne; Oliveira, Marisa; Li, Hanqi; Di, Ying; Christensen, Maria H.; Paulo, Joao A.; Antrobus, Robin; Gygi, Steven P.; Schmidt, Florian I.; Huttlin, Edward L.; Smith, Geoffrey L.; Weekes, Michael P.
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An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation
err2023-07-01
err17
errOAAI
errYiu, Stephanie Pei Tung; Zerbe, Cassie; Vanderwall, David; Huttlin, Edward L.; Weekes, Michael P.; Gewurz, Benjamin E.
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Article Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity
err2023-06-01
err10
errOAAI
errPotts, Martin; Fletcher-Etherington, Alice; Nightingale, Katie; Mescia, Federica; Bergamaschi, Laura; Calero-Nieto, Fernando J.; Antrobus, Robin; Williamson, James; Parsons, Harriet; Huttlin, Edward L.; Kingston, Nathalie; Gottgens, Berthold; Bradley, John R.; Lehner, Paul J.; Matheson, Nicholas J.; Smith, Kenneth G. C.; Wills, Mark R.; Lyons, Paul A.; Weekes, Michael P.
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Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility
err2023-03-21
err34
errOAAI
errZhang, Xiaocui; Lavoie, Genevieve; Fort, Loic; Huttlin, Edward L.; Tcherkezian, Joseph; Galan, Jacob A.; Gu, Haihua; Gygi, Steven P.; Carreno, Sebastien; Roux, Philippe P.
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Phosphorylation of the Eukaryotic Translation Initiation Factor 4E-Transporter (4E-T) by c-Jun N-Terminal Kinase Promotes Stress-Dependent P-Body Assembly
err2023-03-20
err38
errOAAI
errCargnello, Marie; Tcherkezian, Joseph; Dorn, Jonas F.; Huttlin, Edward L.; Maddox, Paul S.; Gygi, Steven P.; Roux, Philippe P.
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TIMMDC1/C3orf1 Functions as a Membrane-Embedded Mitochondrial Complex I Assembly Factor through Association with the MCIA Complex
err2023-03-20
err88
errOAAI
errGuarani, Virginia; Paulo, Joao; Zhai, Bo; Huttlin, Edward L.; Gygi, Steven P.; Harper, J. Wade
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Human Polo-like Kinase Inhibitors as Antiplasmodials
err2023-03-15
err3
errOAAI
errBohmer, Monica J.; Wang, Jinhua; Istvan, Eva S.; Luth, Madeline R.; Collins, Jennifer E.; Huttlin, Edward L.; Wang, Lushun; Mittal, Nimisha; Hao, Mingfeng; Kwiatkowski, Nicholas P.; Gygi, Steven P.; Chakrabarti, Ratna; Deng, Xianming; Goldberg, Daniel E.; Winzeler, Elizabeth A.; Gray, Nathanael S.; Chakrabarti, Debopam
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Sample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression
err2023-02-02
err15
errOAAI
errYu, Qing; Liu, Xinyue; Keller, Mark P.; Navarrete-Perea, Jose; Zhang, Tian; Fu, Sipei; Vaites, Laura P.; Shuken, Steven R.; Schmid, Ernst; Keele, Gregory R.; Li, Jiaming; Huttlin, Edward L.; Rashan, Edrees H.; Simcox, Judith; Churchill, Gary A.; Schweppe, Devin K.; Attie, Alan D.; Paulo, Joao A.; Gygi, Steven P.
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A proteome-wide atlas of drug mechanism of action
err2023-01-02
err45
PREAI
errMitchell, Dylan C. C.; Kuljanin, Miljan; Li, Jiaming; Van Vranken, Jonathan G. G.; Bulloch, Nathan; Schweppe, Devin K. K.; Huttlin, Edward L. L.; Gygi, Steven P. P.
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A multi-purpose, regenerable, proteome-scale, human phosphoserine resource for phosphoproteomics
err2022-10-24
err21
errOAAI
errGassaway, Brandon M.; Li, Jiaming; Rad, Ramin; Mintseris, Julian; Mohler, Kyle; Levy, Tyler; Aguiar, Mike; Beausoleil, Sean A.; Paulo, Joao A.; Rinehart, Jesse; Huttlin, Edward L.; Gygi, Steven P.
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Proteome-wide mapping of short-lived proteins in human cells
err2021-11-01
err61
errOAAI
errLi, Jiaming; Cai, Zhenying; Vaites, Laura Pontano; Shen, Ning; Mitchell, Dylan C.; Huttlin, Edward L.; Paulo, Joao A.; Harry, Brian L.; Gygi, Steven P.
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Selection of Heating Temperatures Improves the Sensitivity of the Proteome Integral Solubility Alteration Assay
err2020-04-03
err46
errOAAI
errLi, Jiaming; Van Vranken, Jonathan G.; Paulo, Joao A.; Huttlin, Edward L.; Gygi, Steven P.
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