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M

Mark Skehel

The Francis Crick Institute

64H-index
238Paper Count
1.5WCitation Count
Published Papers 89
Publication Date
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Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery
errAngewandte Chemie International Edition
IF16.9
err2026-07-10
err0
errOAAI
errJessica E. Waters; Harry Wilders; George S. Biggs; Mika Kintzel; Emma E. Cawood; Jonathan Bailey; Sarah Maslen; Yew Mun Yip; Mason Wakley; Ioannis G. Riziotis; Thomas W. Rees; Joanna Redmond; J. Mark Skehel; David House; Jacob Bush; Jeannine Hess
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errSave
The genetic and biochemical basis of human leading strand synthesis
errNature Communications
IF15.7
err2025-12-04
err0
errOAAI
errAlessandro Agnarelli; Lauryn Buckley-Benbow; Meryem Ozgencil; Melanie Lad; Khamal Kwesi Ampah; Alex Kalinka; Ondrej Belan; Sarah Maslen; Mark J. Skehel; David Walter; Matthew Day; Roberto Bellelli
errShare
errSave
GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome
errNature Communications
IF15.7
err2025-11-13
err0
errOAAI
errAlžběta Roeselová; Sarah L. Maslen; Jessica Zhiyun He; Gabija Jurkeviciute; Aleksandra Pajak; J. Mark Skehel; Radoslav I. Enchev; David Balchin
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errSave
Light-Activated Metal-Dependent Protein Degradation: A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2025-11-01
err0
PREAI
errStevens-Cullinane, Lars; Rees, Thomas W.; Evans, Calum; Ho, Po-Yu; Kintzel, Mika; Yip, Yew Mun; Jia, Ruoning; Bailey, Jonathan; Clifford, Eleanor; Alam, Ruqaiya; Maslen, Sarah; Mouilleron, Stephane; Pasquier, Adrien; Song, Ok-Ryul; Warchal, Scott; Redmond, Joanna; Howell, Michael; Kjaer, Svend; Skehel, Mark; Muller, Manuel M.; Johnson, Eachan O.; Roessler, Maxie M.; Hess, Jeannine
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errSave
Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2
errRSC Chem. Biol.
IF3.1
err2025-10-29
err0
errOAAI
errCassandra R Kennedy; Katherine McPhie; Aini Vuorinen; Jane Dudley-Fraser; Diego Esposito; Sarah L Maslen; William McCarthy; Jonathan Pettinger; J. Mark Skehel; Jacob T. Bush; David House; Katrin Rittinger
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errSave
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
errNature Structural & Molecular Biology
IF10.1
err2025-09-19
err0
errOAAI
errGrant A. Pellowe; Tomas B. Voisin; Laura Karpauskaite; Sarah L. Maslen; Alžběta Roeselová; J. Mark Skehel; Chloe Roustan; Roger George; Andrea Nans; Svend Kjær; Ian A. Taylor; David Balchin
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errSave
Multi-Omic Analysis Reveals Astrocytic Annexin-A2 as Critical for Network-Level Circadian Timekeeping in the Suprachiasmatic Nucleus
errGLIA
IF5.1
err2025-04-02
err0
errOAAI
errPatton, Andrew P.; Krogager, Toke P.; Maywood, Elizabeth S.; Smyllie, Nicola J.; Morris, Emma L.; Skehel, Mark; Hastings, Michael H.
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errSave
Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation
errCOMMUNICATIONS CHEMISTRY
IF6.2
err2025-01-15
err0
errOAAI
errVuorinen, Aini; Kennedy, Cassandra R.; Mcphie, Katherine A.; Mccarthy, William; Pettinger, Jonathan; Skehel, J. Mark; House, David; Bush, Jacob T.; Rittinger, Katrin
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errSave
Expedited SARS-CoV-2 Main Protease Inhibitor Discovery through Modular 'Direct-to-Biology' Screening
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-12-10
err0
PREAI
errWilders, Harry; Biggs, George; Rowe, Sam M.; Cawood, Emma E.; Riziotis, Ioannis G.; Rendina, Alan R.; Grant, Emma K.; Pettinger, Jonathan; Fallon, David J.; Skehel, Mark; House, David; Tomkinson, Nicholas C. O.; Bush, Jacob T.
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errSave
Plasmodium falciparum protein phosphatase PP7 is required for early ring-stage development
errMBIO
IF4.7
err2024-11-13
err0
errOAAI
errPatel, Avnish; Freville, Aline; Rey, Joshua A.; Flynn, Helen R.; Koussis, Konstantinos; Skehel, Mark J.; Blackman, Michael J.; Baker, David A.
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errSave
The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
errMOLECULAR CELL
IF16.6
err2024-08-01
err2
errOAAI
errTimimi, Lewis; Wrobel, Antoni G.; Chiduza, George N.; Maslen, Sarah L.; Torres-Mendez, Antonio; Montaner, Beatriz; Davis, Colin; Minckley, Taylor; Hole, Katriona L.; Serio, Andrea; Devine, Michael J.; Skehel, J. Mark; Rubinstein, John L.; Schreiber, Anne; Beale, Rupert
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errSave
Mechanism of chaperone coordination during cotranslational protein folding in bacteria
errMOLECULAR CELL
IF16.6
err2024-07-01
err1
errOAAI
errRoeselova, Alzbeta; Maslen, Sarah L.; Shivakumaraswamy, Santosh; Pellowe, Grant A.; Howell, Steven; Joshi, Dhira; Redmond, Joanna; Kjaer, Svend; Skehel, J. Mark; Balchin, David
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errSave
Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites
errPLOS PATHOGENS
IF4.9
err2024-06-27
err1
errOAAI
errKoussis, Konstantinos; Haase, Silvia; Withers-Martinez, Chrislaine; Flynn, Helen R.; Kunzelmann, Simone; Christodoulou, Evangelos; Ibrahim, Fairouz; Skehel, Mark; Baker, David A.; Blackman, Michael J.
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errSave
Multi-signal regulation of the GSK-3β homolog Rim11 controls meiosis entry in budding yeast
errEMBO JOURNAL
IF8.3
err2024-06-17
err0
errOAAI
errKociemba, Johanna; Jorgensen, Andreas Christ Solvsten; Tadic, Nika; Harris, Anthony; Sideri, Theodora; Chan, Wei Yee; Ibrahim, Fairouz; Unal, Elcin; Skehel, Mark; Shahrezaei, Vahid; Arguello-Miranda, Orlando; van Werven, Folkert Jacobus
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errSave
Exploring the ATG9A interactome uncovers interaction with VPS13A
errJOURNAL OF CELL SCIENCE
IF3.6
err2024-02-22
err8
errOAAI
errVliet, Alexander R. van; Jefferies, Harold B. J.; Faull, Peter A.; Chadwick, Jessica; Ibrahim, Fairouz; Skehel, Mark J.; Tooze, Sharon A.
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errSave
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition
errNEURON
IF15
err2023-10-01
err7
errOAAI
errZiff, Oliver J.; Harley, Jasmine; Wang, Yiran; Neeves, Jacob; Tyzack, Giulia; Ibrahim, Fairouz; Skehel, Mark; Chakrabarti, Anob M.; Kelly, Gavin; Patani, Rickie
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errSave
A chemoproteomic platform for selective deubiquitinase inhibitor discovery
errCELL REPORTS PHYSICAL SCIENCE
IF7.3
err2023-10-01
err4
errOAAI
errCookson, Rosa; Vuorinen, Aini; Pettinger, Jonathan; Kennedy, Cassandra R.; Kirkpatrick, Joanna M.; Peltier-Heap, Rachel E.; Powell, Andrew; Snijders, Ambrosius P.; Skehel, Mark; House, David; Rittinger, Katrin; Bush, Jacob T.
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errSave
The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles
errELIFE
IF0
err2023-07-25
err5
errOAAI
errEnsinck, Imke; Maman, Alexander; Albihlal, Waleed S.; Lassandro, Michelangelo; Salzano, Giulia; Sideri, Theodora; Howell, Steven A.; Calvani, Enrica; Patel, Harshil; Bushkin, Guy; Ralser, Markus; Snijders, Ambrosius P.; Skehel, Mark; Casanal, Ana; Schwartz, Schraga; van Werven, Folkert J.
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errSave
Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange
errMOLECULAR CELL
IF16.6
err2023-07-01
err9
errOAAI
errShaaban, Mohammed; Clapperton, Julie A.; Ding, Shan; Kunzelmann, Simone; Maeots, Mart-Erik; Maslen, Sarah L.; Skehel, J. Mark; Enchev, Radoslav I.
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errSave
Bacillus subtilis YtpP and Thioredoxin A Are New Players in the Coenzyme-A-Mediated Defense Mechanism against Cellular Stress
errANTIOXIDANTS
IF6.6
err2023-04-15
err4
errOAAI
errTossounian, Maria-Armineh; Baczynska, Maria; Dalton, William; Peak-Chew, Sew Yeu; Undzenas, Kipras; Korza, George; Filonenko, Valeriy; Skehel, Mark; Setlow, Peter; Gout, Ivan
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Ruedi Aebersold
H-index: 198 · Papers: 1.2K
S
Stephen J. Elledge
H-index: 172 · Papers: 542
P
Philip Cohen
H-index: 156 · Papers: 581
M
Michael P. Murphy
H-index: 142 · Papers: 777
C
Charles Swanton
H-index: 137 · Papers: 1.2K
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