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Frederick P. Roth

Dana-Farber Cancer Institute

79H-index
276Paper Count
4.0WCitation Count
Published Papers 112
Publication Date
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Experimental assessment of AI-based interactome mapping
errNature Communications
IF15.7
err2026-04-04
err0
errOAAI
errLuke Lambourne; Anupama Yadav; Yang Wang; Alice Desbuleux; Dae-Kyum Kim; Florent Laval; Kerstin Spirohn-Fitzgerald; Tiziana Cafarelli; Carles Pons; István A. Kovács; Noor Jailkhani; Sadie Schlabach; David De Ridder; Katja Luck; Vladimir V. Botchkarev; Olivia Debnath; Wenting Bian; Yun Shen; Zhipeng Yang; Miles W. Mee; Mohamed Helmy; Yves Jacob; Irma Lemmens; Thomas Rolland; Gregory G. McClain; Atina G. Coté; Marinella Gebbia; Nishka Kishore; Jennifer J. Knapp; Joseph C. Mellor; Gonen Memisoglu; Jüri Reimand; Jan Tavernier; Michael E. Cusick; Quan Zhong; Patrick Aloy; Tong Hao; Benoit Charloteaux; Frederick P. Roth; Javier De Las Rivas; Pascal Falter-Braun; David E. Hill; Michael A. Calderwood; Jean-Claude Twizere; Marc Vidal
errShare
errSave
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR
errScience
IF45.8
err2025-10-30
err0
PREAI
errDaniel R. Tabet; Atina G. Coté; Megan C. Lancaster; Jochen Weile; Ashyad Rayhan; Iosifina Fotiadou; Nishka Kishore; Roujia Li; Da Kuang; Jennifer J. Knapp; Carmela S. Carrero; Olivia Taverniti; Anna Axakova; Jack M. P. Castelli; Mohammad M. Islam; Shahin Sowlati-Hashjin; Aanshi Gandhi; Ranim Maaieh; Michael Garton; Kenneth Matreyek; Douglas M. Fowler; Mafalda Bourbon; Simon G. Pfisterer; Andrew M. Glazer; Brett M. Kroncke; Victoria N. Parikh; Euan A. Ashley; Joshua W. Knowles; Melina Claussnitzer; Elizabeth T. Cirulli; Robert A. Hegele; Dan M. Roden; Calum A. MacRae; Frederick P. Roth
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errSave
Landscapes of missense variant impact for human superoxide dismutase 1
erramerican journal of human genetics
IF0
err2025-09-15
err0
errOAAI
errAnna Axakova; Megan Ding; Atina G. Cote; Radha Subramaniam; Vignesh Senguttuvan; Haotian Zhang; Jochen Weile; Samuel V. Douville; Marinella Gebbia; Ammar Al-Chalabi; Alexander Wahl; Jason Reuter; Jessica Hurt; Adele A. Mitchell; Stephanie Fradette; Peter M. Andersen; Warren van Loggerenberg; Frederick P. Roth
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errSave
Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine
errNature Reviews Cardiology
IF44.2
err2025-09-01
err0
PREAI
errAndrew M. Glazer; Daniel R. Tabet; Victoria N. Parikh; Brett M. Kroncke; Atina G. Cote; Yuta Yamamoto; Qianru Wang; Ayesha Muhammad; Megan C. Lancaster; Matthew J. O’Neill; Jochen Weile; Tao Yang; Calum A. Macrae; Euan A. Ashley; Frederick P. Roth; Dan M. Roden
errShare
errSave
Guidelines for releasing a variant effect predictor
errGENOME BIOLOGY
IF9.4
err2025-04-15
err1
errOAAI
errLivesey, Benjamin J.; Badonyi, Mihaly; Dias, Mafalda; Frazer, Jonathan; Kumar, Sushant; Lindorff-Larsen, Kresten; Mccandlish, David M.; Orenbuch, Rose; Shearer, Courtney A.; Muffley, Lara; Foreman, Julia; Glazer, Andrew M.; Lehner, Ben; Marks, Debora S.; Roth, Frederick P.; Rubin, Alan F.; Starita, Lea M.
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errSave
Leveraging cancer mutation data to inform the pathogenicity classification of germline missense variants
errPLOS GENETICS
IF3.7
err2025-01-06
err0
errOAAI
errHaque, Bushra; Cheerie, David; Pan, Amy; Curtis, Meredith; Nalpathamkalam, Thomas; Nguyen, Jimmy; Salhab, Celine; Thiruvahindrapuram, Bhooma; Zhang, Jade; Couse, Madeline; Hartley, Taila; Morrow, Michelle M.; Price, E. Magda; Walker, Susan; Malkin, David; Roth, Frederick P.; Costain, Gregory
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errSave
A comprehensive two-hybrid analysis to explore the Legionella pneumophila effector-effector interactome
errMSYSTEMS
IF4.6
err2024-12-17
err1
errOAAI
errMount, Harley O'Connor; Urbanus, Malene L.; Sheykhkarimli, Dayag; Cote, Atina G.; Laval, Florent; Coppin, Georges; Kishore, Nishka; Li, Roujia; Spirohn-Fitzgerald, Kerstin; Petersen, Morgan O.; Knapp, Jennifer J.; Kim, Dae-Kyum; Twizere, Jean-Claude; Calderwood, Michael A.; Vidal, Marc; Roth, Frederick P.; Ensminger, Alexander W.
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errSave
A missense variant effect map for the human tumor-suppressor protein CHK2
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2024-12-01
err0
PREAI
errGebbia, Marinella; Zimmerman, Daniel; Jiang, Rosanna; Nguyen, Maria; Weile, Jochen; Li, Roujia; Gavac, Michelle; Kishore, Nishka; Sun, Song; Boonen, Rick A.; Hamilton, Rayna; Dines, Jennifer N.; Wahl, Alexander; Reuter, Jason; Johnson, Britt; Fowler, Douglas M.; Couch, Fergus J.; van Attikum, Haico; Roth, Frederick P.
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Assessing predictions on fitness effects of missense variants in HMBS in CAGI6
errHUMAN GENETICS
IF3.6
err2024-08-07
err0
PREAI
errZhang, Jing; Kinch, Lisa; Katsonis, Panagiotis; Lichtarge, Olivier; Jagota, Milind; Song, Yun S.; Sun, Yuanfei; Shen, Yang; Kuru, Nurdan; Dereli, Onur; Adebali, Ogun; Alladin, Muttaqi Ahmad; Pal, Debnath; Capriotti, Emidio; Turina, Maria Paola; Savojardo, Castrense; Martelli, Pier Luigi; Babbi, Giulia; Casadio, Rita; Pucci, Fabrizio; Rooman, Marianne; Cia, Gabriel; Tsishyn, Matsvei; Strokach, Alexey; Hu, Zhiqiang; van Loggerenberg, Warren; Roth, Frederick P.; Radivojac, Predrag; Brenner, Steven E.; Cong, Qian; Grishin, Nick V.
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errSave
Benchmarking computational variant effect predictors by their ability to infer human traits
errGENOME BIOLOGY
IF9.4
err2024-07-01
err0
errOAAI
errTabet, Daniel R.; Kuang, Da; Lancaster, Megan C.; Li, Roujia; Liu, Karen; Weile, Jochen; Cote, Atina G.; Wu, Yingzhou; Hegele, Robert A.; Roden, Dan M.; Roth, Frederick P.
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errSave
Minimum information and guidelines for reporting a multiplexed assay of variant effect
errGENOME BIOLOGY
IF9.4
err2024-04-19
err0
errOAAI
errClaussnitzer, Melina; Parikh, Victoria N.; Wagner, Alex H.; Arbesfeld, Jeremy A.; Bult, Carol J.; Firth, Helen V.; Muffley, Lara A.; Ba, Alex N. Nguyen; Riehle, Kevin; Roth, Frederick P.; Tabet, Daniel; Bolognesi, Benedetta; Glazer, Andrew M.; Rubin, Alan F.
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errSave
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay
errGENOME BIOLOGY
IF9.4
err2024-04-16
err0
errOAAI
errGersing, Sarah; Schulze, Thea K.; Cagiada, Matteo; Stein, Amelie; Roth, Frederick P.; Lindorff-Larsen, Kresten; Hartmann-Petersen, Rasmus
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errSave
Workshop report: the clinical application of data from multiplex assays of variant effect (MAVEs), 12 July 2023
errEUROPEAN JOURNAL OF HUMAN GENETICS
IF4.6
err2024-03-04
err1
errOAAI
errAllen, Sophie; Garrett, Alice; Muffley, Lara; Fayer, Shawn; Foreman, Julia; Adams, David J.; Hurles, Matthew; Rubin, Alan F.; Roth, Frederick P.; Starita, Lea M.; Biesecker, Leslie G.; Turnbull, Clare
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errSave
Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2023-10-01
err8
errOAAI
errvan Loggerenberg, Warren; Sowlati-Hashjin, Shahin; Weile, Jochen; Hamilton, Rayna; Chawla, Aditya; Sheykhkarimli, Dayag; Gebbia, Marinella; Kishore, Nishka; Fresard, Laure; Mustajoki, Sami; Pischik, Elena; Di Pierro, Elena; Barbaro, Michela; Floderus, Ylva; Schmitt, Caroline; Gouya, Laurent; Colavin, Alexandre; Nussbaum, Robert; Friesema, Edith C. H.; Kauppinen, Raili; To-Figueras, Jordi; Aarsand, Aasne K.; Desnick, Robert J.; Garton, Michael; Roth, Frederick P.
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errSave
Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
errMOLECULAR CELL
IF16.6
err2023-08-01
err6
errOAAI
errZhao, Yichao; Tabet, Daniel; Contreras, Diana Rubio; Lao, Linjiang; Kousholt, Arne Nedergaard; Weile, Jochen; Melo, Henrique; Hoeg, Lisa; Feng, Sumin; Cote, Atina G.; Lin, Zhen-Yuan; Setiaputra, Dheva; Jonkers, Jos; Gingras, Anne -Claude; Gomez Herreros, Fernando; Roth, Frederick P.; Durocher, Daniel
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errSave
An Atlas of Variant Effects to understand the genome at nucleotide resolution
errGENOME BIOLOGY
IF9.4
err2023-07-03
err29
errOAAI
errFowler, Douglas M.; Adams, David J.; Gloyn, Anna L.; Hahn, William C.; Marks, Debora S.; Muffley, Lara A.; Neal, James T.; Roth, Frederick P.; Rubin, Alan F.; Starita, Lea M.; Hurles, Matthew E.; Ahituv, Nadav; Bahcal, Orli G.; Baldridge, Dustin; Berg, Jonathan S.; Berger, Alice H.; Bianchi, Aisha Haley; Bolognesi, Benedetta; Boutros, Michael; Brenner, Steven; Brush, Matthew H.; Bryant, Vanessa; Bult, Carol J.; Bulyk, Martha; Call, Melissa; Carter, Hannah; Claussnitzer, Melina; Chen, Feng; Cline, Melissa S.; Cuperus, Josh T.; Dawood, Moez; De Jong, Hannah N.; Dias, Mafalda; Dunn, Michael; Engreitz, Jesse; Farh, Kyle; Febbo, Phillip G.; Fields, Stanley; Findlay, Gregory M.; Firth, Helen; Fraser, James S.; Frazer, Jonathan; Frontini, Mattia; Romero, Irene Gallego; Glazer, Andrew M.; Gueler, Murat; Hartmann-Petersen, Rasmus; Houlston, Richard; Huang, Kuan-Lin; Hutter, Carolyn M.; Jagannathan, Sujatha; James, Richard G.; Kampmann, Martin; Karchin, Rachel; Kinney, Justin B.; Komor, Alexis C.; Kosuri, Sriram; Lehner, Ben; Lindorff-Larsen, Kresten; Lombard, Zane; MacArthur, Daniel G.; Martin, Maria; McDermott, Ultan; McNulty, Shannon M.; Ba, Alex N. Nguyen; O'Donnell-Luria, Anne; O'Roak, Brian J.; Parikh, Victoria N.; Parts, Leopold; Pazin, Michael J.; Pesaran, Tina; Petrovski, Slave; Queitsch, Christine; Root, David E.; Shendure, Jay; Spurdle, Amanda B.; Taylor, Kevin L.; Turnbull, Clare; Villen, Judit; Vissers, L. E. L. M.; Wagner, Alex H.; Wakefield, Matthew J.; Weile, Jochen; Xiao, Jenny
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errSave
A comprehensive map of human glucokinase variant activity
errGENOME BIOLOGY
IF9.4
err2023-04-26
err15
errOAAI
errGersing, Sarah; Cagiada, Matteo; Gebbia, Marinella; Gjesing, Anette P.; Cote, Atina G.; Seesankar, Gireesh; Li, Roujia; Tabet, Daniel; Weile, Jochen; Stein, Amelie; Gloyn, Anna L.; Hansen, Torben; Roth, Frederick P.; Lindorff-Larsen, Kresten; Hartmann-Petersen, Rasmus
errShare
errSave
satmut_utils: a simulation and variant calling package for multiplexed assays of variant effect
errGENOME BIOLOGY
IF9.4
err2023-04-20
err1
errOAAI
errHoskins, Ian; Sun, Song; Cote, Atina; Roth, Frederick P.; Cenik, Can
errShare
errSave
Next-generation large-scale binary protein interaction network for Drosophila melanogaster
errNATURE COMMUNICATIONS
IF15.7
err2023-04-15
err10
errOAAI
errTang, Hong-Wen; Spirohn, Kerstin; Hu, Yanhui; Hao, Tong; Kovacs, Istvan A.; Gao, Yue; Binari, Richard; Yang-Zhou, Donghui; Wan, Kenneth H.; Bader, Joel S.; Balcha, Dawit; Bian, Wenting; Booth, Benjamin W.; Cote, Atina G.; de Rouck, Steffi; Desbuleux, Alice; Goh, Kah Yong; Kim, Dae-Kyum; Knapp, Jennifer J.; Lee, Wen Xing; Lemmens, Irma; Li, Cathleen; Li, Mian; Li, Roujia; Lim, Hyobin Julianne; Liu, Yifang; Luck, Katja; Markey, Dylan; Pollis, Carl; Rangarajan, Sudharshan; Rodiger, Jonathan; Schlabach, Sadie; Shen, Yun; Sheykhkarimli, Dayag; TeeKing, Bridget; Roth, Frederick P.; Tavernier, Jan; Calderwood, Michael A.; Hill, David E.; Celniker, Susan E.; Vidal, Marc; Perrimon, Norbert; Mohr, Stephanie E.
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errSave
LARGE-SCALE TESTING OF AGXT MISSENSE VARIANT EFFECTS
errMOLECULAR GENETICS AND METABOLISM
IF3.5
err2023-03-01
err0
PREAI
errde Souza, Adrine; Kishore, Nishka; Li, Roujia; Dai, Ziyi; van Loggerenberg, Warren; Rayhan, Ashyad; Tucker, Chandra L.; Gebbia, Marinella; Cote, Atina G.; Roth, Frederick P.
errShare
errSave

Research Directions

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