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Michael Regnier

university of washington seattle

52H-index
385Paper Count
1.2WCitation Count
Published Papers 169
Publication Date
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The hypertrophic cardiomyopathy myosin variant G256E prolongs cardiac muscle relaxation via altered nucleotide handling
errCommunications Chemistry
IF6.2
err2026-05-05
err0
errOAAI
errKerry Y. Kao; Matthew Carter Childers; Divya Pathak; Rama Reddy Goluguri; Timothy S. McMillen; Joseph D. Powers; Kathleen M. Ruppel; James A. Spudich; Michael Regnier
errShare
errSave
Functional interrogation of contextually correct MYH7 variants using CRaTER-flox gene editing and contractility profiling
errJournal of Clinical Investigation
IF13.6
err2026-01-16
err1
errOAAI
errLoiben, Alexander M.; Chien, Wei-Ming; Mckinstry, Ashley; Ahmed, Dania; Childers, Matthew C.; Regnier, Michael; Murry, Charles E.; Yang, Kai-Chun
errShare
errSave
Myosin Modulator Aficamten Inhibits Force by Altering Myosin's Biochemical Activity Without Changing Thick Filament Structure
errJACC-BASIC TO TRANSLATIONAL SCIENCE
IF7.2
err2026-01-01
err0
errOAAI
errMohran, Saffie; Kooiker, Kristina B.; Naim, Ateeqa; Pilagov, Matvey; Asencio, Anthony; Turner, Kyrah L.; Ma, Weikang; Flint, Galina; Jiang, Siyao; Zhao, Jing; Mcmillen, Timothy S.; Mandrycky, Christian; Mahoney-Schaefer, Max; Irving, Thomas C.; Tanner, Bertrand C. W.; Kad, Neil M.; Regnier, Michael; Moussavi-Harami, Farid
errShare
errSave
Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically
errNature Communications
IF15.7
err2025-10-01
err0
errOAAI
errNeha Nandwani; Debanjan Bhowmik; Camille Glaser; Matthew Carter Childers; Rama Reddy Goluguri; Aminah Dawood; Michael Regnier; Anne Houdusse; James A. Spudich; Kathleen M. Ruppel
errShare
errSave
Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy
errScience
IF45.8
err2025-09-11
err0
PREAI
errRoss C. Bretherton; Isabella M. Reichardt; Kristin A. Zabrecky; Abigail Nagle; Logan R. J. Bailey; Darrian Bugg; Sasha Smolgovsky; Amy L. Gifford; Timothy S. McMillen; Alex J. Goldstein; Kristina B. Kooiker; Galina V. Flint; Amy Martinson; Jagdambika Gunaje; Franziska Koser; Elizabeth Plaster; Wolfgang A. Linke; Michael Regnier; Farid Moussavi-Harami; Nathan J. Sniadecki; Cole A. DeForest; Jennifer Davis
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errSave
Monitoring in real time and far-red imaging of H2O2 dynamics with subcellular resolution
errNATURE CHEMICAL BIOLOGY
IF13.7
err2025-04-28
err0
PREAI
errLee, Justin Daho; Nguyen, Amanda; Gibbs, Chelsea E.; Jin, Zheyu Ruby; Wang, Yuxuan; Moghadasi, Aida; Wait, Sarah J.; Choi, Hojun; Evitts, Kira M.; Asencio, Anthony; Bremner, Samantha B.; Zuniga, Shani; Chavan, Vedant; Pranoto, Inez K. A.; Williams, C. Andrew; Smith, Annette; Moussavi-Harami, Farid; Regnier, Michael; Baker, David; Young, Jessica E.; Mack, David L.; Nance, Elizabeth; Boyle, Patrick M.; Berndt, Andre
errShare
errSave
Dual role of Tropomyosin-R160 in thin filament regulation: Insights into phosphorylation-dependent cardiac relaxation and cardiomyopathy mechanisms
errARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
IF3
err2025-03-01
err0
PREAI
errBarry, Meaghan E.; Rynkiewicz, Michael J.; Wen, Jian; Tu, An-Yue; Regnier, Michael; Lehman, William; Moore, Jeffrey R.
errShare
errSave
RETRACTION: dATP elevation induces myocardial metabolic remodeling to support improved cardiac function
errJOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
IF4.7
err2024-12-01
err0
PREAI
errMhatre, Ketaki N.; Murray, Jason D.; Flint, Galina; Mcmillen, Timothy S.; Weber, Gerhard; Shakeri, Majid; Tu, An-Yue; Steczina, Sonette; Weiss, Robert; Marcinek, David J.; Murry, Charles E.; Raftery, Daniel; Tian, Rong; Moussavi-Harami, Farid; Regnier, Michael
errShare
errSave
Interacting myosin head dynamics and their modification by 2'-deoxy-ADP
errBIOPHYSICAL JOURNAL
IF3.1
err2024-11-01
err1
PREAI
errChilders, Matthew Carter; Geeves, Michael A.; Regnier, Michael
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errSave
Noncontractile Stem Cell-Cardiomyocytes Preserve Post-Infarction Heart Function
errCIRCULATION RESEARCH
IF16.2
err2024-10-11
err0
PREAI
errKarbassi, Elaheh; Yoo, Dasom; Martinson, Amy M.; Yang, Xiulan; Reinecke, Hans; Regnier, Michael; Murry, Charles E.
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errSave
Calcium has a direct effect on thick filament activation in porcine myocardium
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2024-09-20
err2
errOAAI
errMohran, Saffie; McMillen, Timothy S.; Mandrycky, Christian; Tu, An-Yue; Kooiker, Kristina B.; Qian, Wenjing; Neys, Stephanie; Osegueda, Brayan; Moussavi-Harami, Farid; Irving, Thomas C.; Regnier, Michael; Ma, Weikang
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errSave
Multiscale modeling shows how 2'-deoxy-ATP rescues ventricular function in heart failure
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-08-22
err0
PREAI
errTeitgen, Abigail E.; Hock, Marcus T.; Mccabe, Kimberly J.; Childers, Matthew C.; Huber, Gary A.; Marzban, Bahador; Beard, Daniel A.; McCammon, J. Andrew; Regnier, Michael; McCulloch, Andrew D.
errShare
errSave
Mechanisms of a novel regulatory light chain-dependent cardiac myosin inhibitor
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2024-07-31
err1
PREAI
errKooiker, Kristina; Gan, Qing-Fen; Yu, Ming; Sa, Na; Mohran, Saffie; Cheng, Yuanhua; Flint, Galina; Neys, Stephanie; Gao, Chengqian; Nissen, Devin; McMillen, Tim; Asencio, Anthony; Ma, Weikang; Irving, Thomas C.; Moussavi-Harami, Farid; Regnier, Michael
errShare
errSave
Aficamten reduces cardiac contractility by modifying the actomyosin interaction
errcardiovascular research
IF10.8
err2024-07-23
err0
PREAI
errMoussavi-Harami, Farid; Regnier, Michael
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errSave
Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways
errGEROSCIENCE
IF5.4
err2024-07-08
err2
errOAAI
errDaneshgar, Nastaran; Lan, Renny; Regnier, Michael; Mackintosh, Samuel G.; Venkatasubramanian, Ravinandan; Dai, Dao-Fu
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errSave
Keeping it fresh: ribosomal protein SA sustains sarcomeric function via localized translation
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2024-07-01
err0
errOAAI
errNagle, Abigail; Regnier, Michael; Davis, Jennifer
errShare
errSave
MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States
errCIRCULATION
IF38.6
err2024-06-04
err2
errOAAI
errBailey, Logan R. J.; Bugg, Darrian; Reichardt, Isabella M.; Ortac, C. Dessiree; Nagle, Abigail; Gunaje, Jagadambika; Martinson, Amy; Johnson, Richard; Maccoss, Michael J.; Sakamoto, Tomoya; Kelly, Daniel P.; Regnier, Michael; Davis, Jennifer
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errSave
MYBPC3-c.772G > A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy
errJOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
IF4.7
err2024-06-01
err2
PREAI
errSteczina, Sonette; Mohran, Saffie; Bailey, Logan R. J.; McMillen, Timothy S.; Kooiker, Kristina B.; Wood, Neil B.; Davis, Jennifer; Previs, Michael J.; Olivotto, Iacopo; Pioner, Jose Manuel; Geeves, Michael A.; Poggesi, Corrado; Regnier, Michael
errShare
errSave
Incomplete- penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-04-29
err3
errOAAI
errLee, Soah; Roestd, Alison S. Vander; Blair, Cheavar A.; Kaoh, Kerry; Bremner, Samantha B.; Childers, Matthew C.; Pathak, Divya; Heinrich, Paul; Lee, Daniel; Chirikian, Orlando; Mohran, Saffie E.; Roberts, Brock; Smith, Jacqueline E.; Jahng, James W.; Paik, David T.; Wu, Joseph C.; Gunawardane, Ruwanthi N.; Ruppel, Kathleen M.; Mack, David L.; Pruitt, Beth L.; Regnier, Michael; Wu, Sean M.; Spudich, James A.; Bernstein, Daniel
errShare
errSave
Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2024-04-12
err1
PREAI
errRynkiewicz, Michael J.; Childers, Matthew C.; Karpicheva, Olga E.; Regnier, Michael; Geeves, Michael A.; Lehman, William
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Robert O. Bonow
H-index: 162 · Papers: 1.2K
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Christine E. Seidman
H-index: 151 · Papers: 708
R
Raghu Kalluri
H-index: 142 · Papers: 573
J
Jeffery D. Molkentin
H-index: 141 · Papers: 642
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