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M

Matthias Geyer

university hospital bonn

71H-index
366Paper Count
1.6WCitation Count
Published Papers 144
Publication Date
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Targeting CDKs in the RNAPII transcription cycle
errNature Reviews Drug Discovery
IF101.8
err2026-08-24
err0
PREAI
errRobert P. Fisher; Matthias Geyer
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AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins
errNature Communications
IF15.7
err2026-08-20
err0
errOAAI
errBianca Broske; Benjamin A. McEnroe; Sophie C. Frechen; Tim N. Kempchen; Caroline I. Fandrey; Elisabeth Tan; Dominic Ferber; Michelle C. R. Yong; Marie Kleinert; Julia M. Messmer; Peter Konopka; Alexander Hoch; Katja Blumenstock; Jan M. P. Tödtmann; Johannes Oldenburg; Heiko Rühl; Alexander Semaan; Marieta I. Toma; Kristina Markova; Sebastian Kobold; Tim Rollenske; Matthias Geyer; Stephan Menzel; Tobias Bald; Jonathan L. Schmid-Burgk; Gregor Hagelueken; Michael Hölzel
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Membrane-Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans-Golgi Network
errAdvanced Science
IF14.1
err2026-07-28
err0
errOAAI
errJonas Engelhardt; Nico Kirsch; Aileen Kerfin; Lars P. Lunding; Dominic Ferber; Hannes Buthmann; Ilka Schreier; Carlotta Bosio; Ann-Kathrin Dobbelstein; Anna Klawonn; Rebecca C. Coll; Lena Bauernhofer; Sandro Keller; Matthias Geyer; Michael Wegmann; Andra B. Schromm; Günther Weindl
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Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation
errNature Communications
IF15.7
err2026-05-30
err0
errOAAI
errMaría Mateo-Tórtola; Inga V. Hochheiser; Gaopeng Li; Lukas Funk; Atousa Hashemi; Xiao Liu; Jane Torp; Lena Erlebach; András Szolek; Jelena Grga; Francesca Bork; Jana S. Müller; Deborah Kronenberg-Versteeg; Matthias Geyer; Alexander N. R. Weber; Ana Tapia-Abellán
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Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor
errNature Communications
IF15.7
err2025-12-04
err0
errOAAI
errJessica Nagel; Vigneshwaran Namasivayam; Stephanie Weinhausen; Juan Sierra-Marquez; Younis Baqi; Hashem Ali M. Al Musawi; Aliaa Abdelrahman; Victoria J. Vaaßen; Jonathan G. Schlegel; Lisa Taplick; Jane Torp; Jan Kubicek; Barbara Maertens; Matthias Geyer; Tobias Claff; Annette Nicke; Gregor Hagelueken; Christa E. Müller
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errSave
Targeted Histone Deacetylase Degradation via Chemical Induced Proximity by Direct Recruitment of the CUL4 Complex Adaptor Protein DDB1
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-09-01
err0
PREAI
errZhai, Shiyang; Willemsen, Nicola; Sun, Tao; Malenica, Mateo; Deng, Shixin; Geyer, Matthias; Hansen, Finn K.
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errSave
A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
errMolecular Cell
IF16.6
err2025-08-25
err0
errOAAI
errJennifer R. Devlin; Ben Martin; Nenad Bartonicek; Keziah Ting; Zheng Fan; Izabela Todorovski; Filip Bjelosevic; Sandra Verschoor; Annette Ciccone; Joseph A. Trapani; Attila Horvath; Emily Tinsley; Peter Fraser; Andrea Newbold; Jarrod J. Sandow; Andrea Muscat; Kaylene J. Simpson; Matthias Geyer; Stephin J. Vervoort; Ricky W. Johnstone
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errSave
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets
errNature Immunology
IF27.6
err2025-08-18
err0
PREAI
errAlexander N. R. Weber; Róisín M. McManus; Veit Hornung; Matthias Geyer; Jasmin B. Kuemmerle-Deschner; Eicke Latz
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errSave
Haploinsufficiency of ABL1 is associated with dominant isolated omphalocele
errFrontiers in Cell and Developmental Biology
IF4.3
err2025-08-06
err0
errOAAI
errCaroline M. Kolvenbach; Öznur Yilmaz; Filipa M. Lopes; Jeshurun C. Kalanithy; Katharina Lemberg; Vineeta Sharma; Amar J. Majmundar; Matthias Geyer; Adrian S. Woolf; Friedhelm Hildebrandt; Benjamin Odermatt; Heiko Reutter
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errSave
The inflammasome sensor NLRP3 interacts with REV7 to maintain genome integrity through homologous recombination
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-07-08
err0
errOAAI
errBurlet, Delphine; Khan, Md Muntaz; Hacot, Sabine; Buthmann, Hannes; Bardoulet, Lea; Huber, Anne-Laure; Gorry, Julie; Foehr, Bastian; Lopez, Bernard S.; Coute, Yohann; Faesen, Alex C.; Geyer, Matthias; Tissier, Agnes; Petrilli, Virginie
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errSave
Discovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K
errRSC CHEMICAL BIOLOGY
IF3.1
err2025-01-01
err0
errOAAI
errGhosh, Pompom; Schmitz, Maximilian; Pandurangan, Thiyagamurthy; Zeleke, Solomon Tadesse; Chan, Sean Chin; Mosior, John; Sun, Luxin; Palve, Vinayak; Grassie, Dylan; Anand, Kanchan; Frydman, Sylvia; Roush, William R.; Schonbrunn, Ernst; Geyer, Matthias; Duckett, Derek; Monastyrskyi, Andrii
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Degrading the key component of the inflammasome: development of an NLRP3 PROTAC
errCHEMICAL COMMUNICATIONS
IF4.2
err2025-01-01
err0
PREAI
errKeuler, Tim; Ferber, Dominic; Engelhardt, Jonas; Steinebach, Christian; Kirsch, Nico; Marleaux, Michael; Weindl, Guenther; Geyer, Matthias; Guetschow, Michael
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errSave
RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I
errEMBO JOURNAL
IF8.3
err2024-12-20
err0
errOAAI
errKirchhoff, Alexander; Herzner, Anna-Maria; Urban, Christian; Piras, Antonio; Duester, Robert; Mahlberg, Julia; Gruenewald, Agathe; Schlee-Guimaraes, Thais M.; Ciupka, Katrin; Leka, Petro; Bootz, Robert J.; Wallerath, Christina; Hunkler, Charlotte; de Regt, Ann Kristin; Kuemmerer, Beate M.; Christensen, Maria Honholt; Schmidt, Florian, I; Lee-Kirsch, Min Ae; Guenther, Claudia; Kato, Hiroki; Bartok, Eva; Hartmann, Gunther; Geyer, Matthias; Pichlmair, Andreas; Schlee, Martin
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Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models
errEUROPEAN JOURNAL OF HUMAN GENETICS
IF4.6
err2024-12-19
err0
errOAAI
errIshorst, Nina; Hoelzel, Selina; Greve, Carola; Yilmaz, Oeznur; Lindenberg, Tobias; Lambertz, Jessica; Drichel, Dmitriy; Zametica, Berina; Mingardo, Enrico; Kalanithy, Jeshurun C.; Channab, Khadija; Kibris, Duygu; Henne, Sabrina; Degenhardt, Franziska; Siewert, Anna; Dixon, Michael; Kruse, Teresa; Ongkosuwito, Edwin; Girisha, Katta M.; Pande, Shruti; Nowak, Stefanie; Hagelueken, Gregor; Geyer, Matthias; Carels, Carine; van Rooij, Iris A. L. M.; Ludwig, Kerstin U.; Odermatt, Benjamin; Mangold, Elisabeth
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Insights into reproduction-regulating NOD-like receptors
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2024-10-08
err0
PREAI
errHochheiser, Inga V.; Geyer, Matthias
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errSave
Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application
errNATURE COMMUNICATIONS
IF15.7
err2024-09-26
err0
errOAAI
errSchiffelers, Lisa D. J.; Tesfamariam, Yonas M.; Jenster, Lea-Marie; Diehl, Stefan; Binder, Sophie C.; Normann, Sabine; Mayr, Jonathan; Pritzl, Steffen; Hagelauer, Elena; Kopp, Anja; Alon, Assaf; Geyer, Matthias; Ploegh, Hidde L.; Schmidt, Florian I.
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The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-08-21
err0
errOAAI
errBinder, Sophie C.; Schneberger, Niels; Schmitz, Maximilian; Engeser, Marianne; Geyer, Matthias; Rouillon, Christophe; Hagelueken, Gregor
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errSave
Structural basis of Cdk7 activation by dual T-loop phosphorylation
errNATURE COMMUNICATIONS
IF15.7
err2024-08-03
err1
errOAAI
errDuester, Robert; Anand, Kanchan; Binder, Sophie C.; Schmitz, Maximilian; Gatterdam, Karl; Fisher, Robert P.; Geyer, Matthias
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errSave
A nonsense variant in KRT31 is associated with autosomal dominant monilethrix
errBRITISH JOURNAL OF DERMATOLOGY
IF9.6
err2024-07-19
err1
PREAI
errXiong, Xing; Cesarato, Nicole; Gossmann, Yasmina; Wehner, Maria; Kumar, Sheetal; Thiele, Holger; Demuth, Stephanie; Oji, Vinzenz; Geyer, Matthias; Hamm, Henning; Basmanav, F. Buket; Betz, Regina C.
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errSave
Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2024-03-26
err6
errOAAI
errCosson, Camille; Riou, Romane; Patoli, Danish; Niu, Tingting; Rey, Amaury; Groslambert, Marine; De Rosny, Charlotte; Chatre, Elodie; Allatif, Omran; Henry, Thomas; Venet, Fabienne; Milhavet, Florian; Boursier, Guilaine; Belot, Alexandre; Jamilloux, Yvan; Merlin, Etienne; Duquesne, Agnes; Grateau, Gilles; Savey, Lea; Maria, Alexandre Thibault Jacques; Pagnier, Anne; Poutrel, Solene; Lambotte, Olivier; Mallebranche, Coralie; Ardois, Samuel; Richer, Olivier; Lemelle, Irene; Rieux-Laucat, Frederic; Bader-Meunier, Brigitte; Amoura, Zahir; Melki, Isabelle; Cuisset, Laurence; Touitou, Isabelle; Geyer, Matthias; Georgin-Lavialle, Sophie; Py, Benedicte F.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Aviv Regev
H-index: 208 · Papers: 965
M
Mark J. Smyth
H-index: 172 · Papers: 1.4K
G
Georgina V. Long
H-index: 169 · Papers: 1.8K
M
Markus M. Nöthen
H-index: 161 · Papers: 2.0K
G
Georg Schett
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