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High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation Luteijn, Maartje J.; Bhaskar, Varun; Trojer, Dominic; Schuerz, Melanie; Mahboubi, Hicham; Handl, Cornelia; Pizzato, Nicolas; Pfeifer, Martin; Dafinca, Ruxandra; Voshol, Hans; Giorgetti, Elisa; Manneville, Carole; Garnier, Isabelle P. M.; Mueller, Matthias; Zeng, Fanning; Buntin, Kathrin; Markwalder, Roger; Schroeder, Harald; Weiler, Jan; Khar, Dora; Schuhmann, Tim; Groot-Kormelink, Paul J.; Keller, Caroline Gubser; Farmer, Pierre; MacKay, Angela; Beibel, Martin; Roma, Guglielmo; D'Ario, Giovanni; Merkl, Claudia; Schebesta, Michael; Hild, Marc; Elwood, Fiona; Vahsen, Bjoern F.; Ripin, Nina; Clery, Antoine; Allain, Frederic; Labow, Mark; Gabriel, Daniela; Chao, Jeffrey A.; Talbot, Kevin; Nash, Mark; Hunziker, Juerg; Meisner-Kober, Nicole C. Share Save
Fast and highly sensitive full-length single-cell RNA sequencing using FLASH-seq Hahaut, Vincent; Pavlinic, Dinko; Carbone, Walter; Schuierer, Sven; Balmer, Pierre; Quinodoz, Mathieu; Renner, Magdalena; Roma, Guglielmo; Cowan, Cameron S.; Picelli, Simone Share Save
Sustained Trem2 stabilization accelerates microglia heterogeneity and Af3 pathology in a mouse model of Alzheimer's disease Dhandapani, Rahul; Neri, Marilisa; Bernhard, Mario; Brzak, Irena; Schweizer, Tatjana; Rudin, Stefan; Joller, Stefanie; Berth, Ramon; Kernen, Jasmin; Neuhaus, Anna; Waldt, Annick; Cuttat, Rachel; Naumann, Ulrike; Keller, Caroline Gubser; Roma, Guglielmo; Feuerbach, Dominik; Shimshek, Derya R.; Neumann, Ulf; Gasparini, Fabrizio; Galimberti, Ivan Share Save
An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion Keller, Caroline Gubser; Shin, Youngah; Monteys, Alex Mas; Renaud, Nicole; Beibel, Martin; Teider, Natalia; Peters, Thomas; Faller, Thomas; St-Cyr, Sophie; Knehr, Judith; Roma, Guglielmo; Reyes, Alejandro; Hild, Marc; Lukashev, Dmitriy; Theil, Diethilde; Dales, Natalie; Cha, Jang-Ho; Borowsky, Beth; Dolmetsch, Ricardo; Davidson, Beverly L.; Sivasankaran, Rajeev Share Save
Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis Ungricht, Rosemarie; Guibbal, Laure; Lasbennes, Marie-Christine; Orsini, Vanessa; Beibel, Martin; Waldt, Annick; Cuttat, Rachel; Carbone, Walter; Basler, Anne; Roma, Guglielmo; Nigsch, Florian; Tchorz, Jan S.; Hoepfner, Dominic; Hoppe, Philipp S. Share Save
CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism Cho, Hyelim; Shen, Qiong; Zhang, Lydia H.; Okumura, Mikiko; Kawakami, Akinori; Ambrose, Jessi; Sigoillot, Frederic; Miller, Howard R.; Gleim, Scott; Cobos-Correa, Amanda; Wang, Ying; Piechon, Philippe; Roma, Guglielmo; Eggimann, Fabian; Moore, Charles; Aspesi, Peter, Jr.; Mapa, Felipa A.; Burks, Heather; Ross, Nathan T.; Krastel, Philipp; Hild, Marc; Maimone, Thomas J.; Fisher, David E.; Nomura, Daniel K.; Tallarico, John A.; Canham, Stephen M.; Jenkins, Jeremy L.; Forrester, William C. Share Save
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation Sun, Tianliang; Annunziato, Stefano; Bergling, Sebastian; Sheng, Caibin; Orsini, Vanessa; Forcella, Pascal; Pikiolek, Monika; Kancherla, Venkatesh; Holwerda, Sjoerd; Imanci, Dilek; Wu, Fabian; Meylan, Ludivine Challet; Puehringer, Lea F.; Waldt, Annick; Oertli, Mevion; Schuierer, Sven; Terracciano, Luigi M.; Reinker, Stefan; Ruffner, Heinz; Bouwmeester, Tewis; Sailer, Andreas W.; George, Elizabeth; Roma, Guglielmo; de Weck, Antoine; Piscuoglio, Salvatore; Lohmann, Felix; Naumann, Ulrike; Liberali, Prisca; Cong, Feng; Tchorz, Jan S. Share Save
Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis Wang, Zhong-Yi; Keogh, Adrian; Waldt, Annick; Cuttat, Rachel; Neri, Marilisa; Zhu, Shanshan; Schuierer, Sven; Ruchti, Alexandra; Crochemore, Christophe; Knehr, Judith; Bastien, Julie; Ksiazek, Iwona; Sanchez-Taltavull, Daniel; Ge, Hui; Wu, Jing; Roma, Guglielmo; Helliwell, Stephen B.; Stroka, Deborah; Nigsch, Florian Share Save
Systematic identification of novel cancer genes through analysis of deep shRNA perturbation screens Montazeri, Hesam; Coto-Llerena, Mairene; Bianco, Gaia; Zangene, Ehsan; Taha-Mehlitz, Stephanie; Paradiso, Viola; Srivatsa, Sumana; de Weck, Antoine; Roma, Guglielmo; Lanzafame, Manuela; Bolli, Martin; Beerenwinkel, Niko; von Fluee, Markus; Terracciano, Luigi M.; Piscuoglio, Salvatore; Ng, Charlotte K. Y. Share Save
Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens Lopes, Rui; Sprouffske, Kathleen; Sheng, Caibin; Uijttewaal, Esther C. H.; Wesdorp, Adriana Emma; Dahinden, Jan; Wengert, Simon; Diaz-Miyar, Juan; Yildiz, Umut; Bleu, Melusine; Apfel, Verena; Mermet-Meillon, Fanny; Krese, Rok; Eder, Mathias; Olsen, Andre Vidas; Hoppe, Philipp; Knehr, Judith; Carbone, Walter; Cuttat, Rachel; Waldt, Annick; Altorfer, Marc; Naumann, Ulrike; Weischenfeldt, Joachim; DeWeck, Antoine; Kauffmann, Audrey; Roma, Guglielmo; Schubeler, Dirk; Galli, Giorgio G. Share Save
PAX8 and MECOM are interaction partners driving ovarian cancer Bleu, Melusine; Mermet-Meillon, Fanny; Apfel, Verena; Barys, Louise; Holzer, Laura; Salvy, Marianne Bachmann; Lopes, Rui; Barbosa, Ines Amorim Monteiro; Delmas, Cecile; Hinniger, Alexandra; Chau, Suzanne; Kaufmann, Markus; Haenni, Simon; Berneiser, Karolin; Wahle, Maria; Moravec, Ivana; Vissieres, Alexandra; Poetsch, Tania; Ahrne, Erik; Carte, Nathalie; Voshol, Johannes; Bechter, Elisabeth; Hamon, Jacques; Meyerhofer, Marco; Erdmann, Dirk; Fischer, Matteo; Stachyra, Therese; Freuler, Felix; Gutmann, Sascha; Fernandez, Cesar; Schmelzle, Tobias; Naumann, Ulrike; Roma, Guglielmo; Lawrenson, Kate; Nieto-Oberhuber, Cristina; Cobos-Correa, Amanda; Ferretti, Stephane; Schuebeler, Dirk; Galli, Giorgio Giacomo Share Save
Mass Cytometry of CSF Identifies an MS-Associated B-cell Population Johansson, David; Rauld, Celine; Roux, Julien; Regairaz, Camille; Galli, Edoardo; Callegari, Ilaria; Raad, Layla; Waldt, Annick; Cuttat, Rachel; Roma, Guglielmo; Diebold, Martin; Becher, Burkhard; Kuhle, Jens; Derfuss, Tobias; Carballido, Jose M.; Sanderson, Nicholas S. R. Share Save
BET bromodomain inhibitors regulate keratinocyte plasticity Schutzius, Gabi; Kolter, Christian; Bergling, Sebastian; Tortelli, Federico; Fuchs, Florian; Renner, Steffen; Guagnano, Vito; Cotesta, Simona; Rueeger, Heinrich; Faller, Michael; Bouchez, Laure; Salathe, Adrian; Nigsch, Florian; Richards, Shola M.; Louis, Malvina; Gruber, Viktoria; Aebi, Alexandra; Turner, Jonathan; Grandjean, Frederic; Li, Jun; Dimitri, Chris; Thomas, Jason R.; Schirle, Markus; Blank, Jutta; Drueckes, Peter; Vaupel, Andrea; Tiedt, Ralph; Manley, Paul W.; Klopp, Julia; Hemmig, Rene; Zink, Florence; Leroy, Nelly; Carbone, Walter; Roma, Guglielmo; Keller, Caroline Gubser; Dales, Natalie; Beyerbach, Armin; Zimmerlin, Alfred; Bonenfant, Debora; Terranova, Remi; Berwick, Amy; Sahambi, Sukhdeep; Reynolds, Aimee; Jennings, Lori L.; Ruffner, Heinz; Tarsa, Peter; Bouwmeester, Tewis; Driver, Vickie; Frederiksen, Mathias; Lohmann, Felix; Kirkland, Susan Share Save
The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice Tuominen, Iina; Fuqua, Brie K.; Pan, Calvin; Renaud, Nicole; Wroblewski, Kevin; Civelek, Mete; Clerkin, Kara; Asaryan, Ashot; Haroutunian, Sara G.; Loureiro, Joseph; Borawski, Jason; Roma, Guglielmo; Knehr, Judith; Carbone, Walter; French, Samuel; Parks, Brian W.; Hui, Simon T.; Mehrabian, Margarete; Magyar, Clara; Cantor, Rita M.; Ukomadu, Chinweike; Lusis, Aldons J.; Beaven, Simon W. Share Save
A Simple and Efficient CRISPR Technique for Protein Tagging Zeng, Fanning; Beck, Valerie; Schuierer, Sven; Garnier, Isabelle; Manneville, Carole; Agarinis, Claudia; Morelli, Lapo; Quinn, Lisa; Knehr, Judith; Roma, Guglielmo; Bassilana, Frederic; Nash, Mark Share Save
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma (vol 13, pg 465, 2019) Ross, Nathan T.; Lohmann, Felix; Carbonneau, Seth; Fazal, Aleem; Weihofen, Wilhelm A.; Gleim, Scott; Salcius, Michael; Sigoillot, Frederic; Henault, Martin; Carl, Sarah H.; Rodriguez-Molina, Juan B.; Miller, Howard R.; Brittain, Scott M.; Murphy, Jason; Zambrowski, Mark; Boynton, Geoffrey; Wang, Yuan; Chen, Aye; Molind, Gregory J.; Wilbertz, Johannes H.; Artus-Revel, Caroline G.; Jia, Min; Akinjiyan, Favour A.; Turner, Jonathan; Knehr, Judith; Carbone, Walter; Schuierer, Sven; Reece-Hoyes, John S.; Xie, Kevin; Saran, Chitra; Williams, Eric T.; Roma, Guglielmo; Spencer, Matt; Jenkins, Jeremy; George, Elizabeth L.; Thomas, Jason R.; Michaud, Gregory; Schirle, Markus; Tallarico, John; Passmore, Lori A.; Chao, Jeffrey A.; Beckwith, Rohan E. J. Share Save
Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis Duraes, Fernanda do Valle; Lafont, Armelle; Beibel, Martin; Martin, Kea; Darribat, Katy; Cuttat, Rachel; Waldt, Annick; Naumann, Ulrike; Wieczorek, Grazyna; Gaulis, Swann; Pfister, Sabina; Mertz, Kirsten D.; Li, Jianping; Roma, Guglielmo; Warncke, Max Share Save
AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration Sun, Tianliang; Pikiolek, Monika; Orsini, Vanessa; Bergling, Sebastian; Holwerda, Sjoerd; Morelli, Lapo; Hoppe, Philipp S.; Planas-Paz, Lara; Yang, Yi; Ruffner, Heinz; Bouwmeester, Tewis; Lohmann, Felix; Terracciano, Luigi M.; Roma, Guglielmo; Cong, Feng; Tchorz, Jan S. Share Save
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma Ross, Nathan T.; Lohmann, Felix; Carbonneau, Seth; Fazal, Aleem; Weihofen, Wilhelm A.; Gleim, Scott; Salcius, Michael; Sigoillot, Frederic; Henault, Martin; Carl, Sarah H.; Rodriguez-Molina, Juan B.; Miller, Howard R.; Brittain, Scott M.; Murphy, Jason; Zambrowski, Mark; Boynton, Geoffrey; Wang, Yuan; Chen, Aye; Molind, Gregory J.; Wilbertz, Johannes H.; Artus-Revel, Caroline G.; Jia, Min; Akinjiyan, Favour A.; Turner, Jonathan; Knehr, Judith; Carbone, Walter; Schuierer, Sven; Reece-Hoyes, John S.; Xie, Kevin; Saran, Chitra; Williams, Eric T.; Roma, Guglielmo; Spencer, Matt; Jenkins, Jeremy; George, Elizabeth L.; Thomas, Jason R.; Michaud, Gregory; Schirle, Markus; Tallarico, John; Passmore, Lori A.; Chao, Jeffrey A.; Beckwith, Rohan E. J. Share Save
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