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B

Brian Hie

stanford university

25H-index
82Paper Count
9.3KCitation Count
Published Papers 21
Publication Date
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Aligning protein-generative models to experimental fitness with ProteinDPO
errNature Methods
IF32.1
err2026-08-14
err0
errOAAI
errTalal Widatalla; Ashir A. Borah; Samuel H. King; Claudia L. Driscoll; Rafael Rafailov; Brian L. Hie
errShare
errSave
Generative design of bacteriophages with genome language models
errScience
IF45.8
err2026-08-06
err0
PREAI
errSamuel H. King; Claudia L. Driscoll; David B. Li; Daniel Guo; Aditi T. Merchant; Garyk Brixi; Max E. Wilkinson; Brian L. Hie
errShare
errSave
Efficient generation of epitope-targeted antibodies with Germinal
errNature Biotechnology
IF41.7
err2026-06-23
err0
PREAI
errLuis S. Mille-Fragoso; Claudia L. Driscoll; John N. Wang; Haoyu Dai; Talal Widatalla; Jim L. Zhang; Xiaowei Zhang; Bing Rao; Liang Feng; Brian L. Hie; Xiaojing J. Gao
errShare
errSave
Genome modelling and design across all domains of life with Evo 2
errNature
IF48.5
err2026-03-04
err0
errOAAI
errGaryk Brixi; Matthew G. Durrant; Jerome Ku; Mohsen Naghipourfar; Michael Poli; Gwanggyu Sun; Greg Brockman; Daniel Chang; Alison Fanton; Gabriel A. Gonzalez; Samuel H. King; David B. Li; Aditi T. Merchant; Eric Nguyen; Chiara Ricci-Tam; David W. Romero; Jonathan C. Schmok; Ali Taghibakhshi; Anton Vorontsov; Brandon Yang; Myra Deng; Liv Gorton; Nam Nguyen; Nicholas K. Wang; Michael T. Pearce; Elana Simon; Etowah Adams; Zachary J. Amador; Euan A. Ashley; Stephen A. Baccus; Haoyu Dai; Steven Dillmann; Stefano Ermon; Daniel Guo; Michael H. Herschl; Rajesh Ilango; Ken Janik; Amy X. Lu; Reshma Mehta; Mohammad R. K. Mofrad; Madelena Y. Ng; Jaspreet Pannu; Christopher Ré; John St. John; Jeremy Sullivan; Joseph Tey; Ben Viggiano; Kevin Zhu; Greg Zynda; Daniel Balsam; Patrick Collison; Anthony B. Costa; Tina Hernandez-Boussard; Eric Ho; Ming-Yu Liu; Thomas McGrath; Kimberly Powell; Sudarshan Pinglay; Dave P. Burke; Hani Goodarzi; Patrick D. Hsu; Brian L. Hie
errShare
errSave
Rapid directed evolution guided by protein language models and epistatic interactions
errScience
IF45.8
err2026-02-19
err0
PREAI
errVincent Q. Tran; Matthew Nemeth; Liam J. Bartie; Sita S. Chandrasekaran; Alison Fanton; Hyungseok C. Moon; Brian L. Hie; Silvana Konermann; Patrick D. Hsu
errShare
errSave
Semantic design of functional de novo genes from a genomic language model
errNature
IF48.5
err2025-11-19
err0
errOAAI
errAditi T. Merchant; Samuel H. King; Eric Nguyen; Brian L. Hie
errShare
errSave
Scanorama: integrating large and diverse single-cell transcriptomic datasets
errNATURE PROTOCOLS
IF16
err2024-06-06
err0
errOAAI
errHie, Brian L.; Kim, Soochi; Rando, Thomas A.; Bryson, Bryan; Berger, Bonnie
errShare
errSave
Generative artificial intelligence for de novo protein design
errCURRENT OPINION IN STRUCTURAL BIOLOGY
IF7
err2024-06-01
err10
errOAAI
errWinnifrith, Adam; Outeiral, Carlos; Hie, Brian L.
errShare
errSave
BHLHE40 Regulates Myeloid Cell Polarization through IL-10-Dependent and -Independent Mechanisms
errJOURNAL OF IMMUNOLOGY
IF3.4
err2024-04-29
err0
PREAI
errHendrix, Skyler, V; Mreyoud, Yassin; McNehlan, Michael E.; Smirnov, Asya; Chavez, Sthefany M.; Hie, Brian; Chamberland, Megan M.; Bradstreet, Tara R.; Webber, Ashlee M.; Kreamalmeyer, Darren; Taneja, Reshma; Bryson, Bryan D.; Edelson, Brian T.; Stallings, Christina L.
errShare
errSave
Large language models for science and medicine
errEUROPEAN JOURNAL OF CLINICAL INVESTIGATION
IF3.6
err2024-02-21
err8
PREAI
errTelenti, Amalio; Auli, Michael; Hie, Brian L.; Maher, Cyrus; Saria, Suchi; Ioannidis, John P. A.
errShare
errSave
Efficient evolution of human antibodies from general protein language models
errNATURE BIOTECHNOLOGY
IF41.7
err2023-04-24
err116
errOAAI
errHie, Brian L. L.; Shanker, Varun R. R.; Xu, Duo; Bruun, Theodora U. J.; Weidenbacher, Payton A. A.; Tang, Shaogeng; Wu, Wesley; Pak, John E. E.; Kim, Peter S. S.
errShare
errSave
Evolutionary velocity with protein language models predicts evolutionary dynamics of diverse proteins
errCELL SYSTEMS
IF7.7
err2022-04-01
err48
errOAAI
errHie, Brian L.; Yang, Kevin K.; Kim, Peter S.
errShare
errSave
Predicting the mutational drivers of future SARS-CoV-2 variants of concern
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2022-02-23
err92
errOAAI
errMaher, M. Cyrus; Bartha, Istvan; Weaver, Steven; di Iulio, Julia; Ferri, Elena; Soriaga, Leah; Lempp, Florian A.; Hie, Brian L.; Bryson, Bryan; Berger, Bonnie; Robertson, David L.; Snell, Gyorgy; Corti, Davide; Virgin, Herbert W.; Pond, Sergei L. Kosakovsky; Telenti, Amalio
errShare
errSave
Adaptive machine learning for protein engineering
errCURRENT OPINION IN STRUCTURAL BIOLOGY
IF7
err2022-02-01
err67
errOAAI
errHie, Brian L.; Yang, Kevin K.
errShare
errSave
Schema: metric learning enables interpretable synthesis of heterogeneous single-cell modalities
errGENOME BIOLOGY
IF9.4
err2021-05-03
err24
errOAAI
errSingh, Rohit; Hie, Brian L.; Narayan, Ashwin; Berger, Bonnie
errShare
errSave
Leveraging Uncertainty in Machine Learning Accelerates Biological Discovery and Design
errCELL SYSTEMS
IF7.7
err2020-11-01
err89
errOAAI
errHie, Brian; Bryson, Bryan D.; Berger, Bonnie
errShare
errSave
Computational Methods for Single-Cell RNA Sequencing
errANNUAL REVIEW OF BIOMEDICAL DATA SCIENCE, VOL 3, 2020
IF0
err2020-07-20
err60
errOAAI
errHie, Brian; Peters, Joshua; Nyquist, Sarah K.; Shalek, Alex K.; Berger, Bonnie; Bryson, Bryan D.
errShare
errSave
Geometric Sketching Compactly Summarizes the Single-Cell Transcriptomic Landscape
errCELL SYSTEMS
IF7.7
err2019-06-01
err79
errOAAI
errHie, Brian; Cho, Hyunghoon; DeMeo, Benjamin; Bryson, Bryan; Berger, Bonnie
errShare
errSave
Efficient integration of heterogeneous single-cell transcriptomes using Scanorama
errNATURE BIOTECHNOLOGY
IF41.7
err2019-05-06
err481
errOAAI
errHie, Brian; Bryson, Bryan; Berger, Bonnie
errShare
errSave
Fine-mapping cis-regulatory variants in diverse human populations
errELIFE
IF0
err2019-01-16
err53
errOAAI
errTehranchi, Ashley; Hie, Brian; Dacre, Michael; Kaplow, Irene; Pettie, Kade; Combs, Peter; Fraser, Hunter B.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
J
John P. A. Ioannidis
H-index: 226 · Papers: 1.9K
H
Herbert W. Virgin
H-index: 132 · Papers: 391
A
Amalio Telenti
H-index: 117 · Papers: 640
E
Euan A. Ashley
H-index: 105 · Papers: 781
T
Thomas A. Rando
H-index: 98 · Papers: 297
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