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E

Ernest Fraenkel

biological engineering

60H-index
295Paper Count
2.1WCitation Count
Published Papers 79
Publication Date
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Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues
errGenome Biology
IF9.4
err2026-03-13
err0
errOAAI
errMario Acera-Mateos; Xian Adiconis; Jessica-Kanglin Li; Domenica Marchese; Ginevra Caratù; Chung-Chau Hon; Prabha Tiwari; Miki Kojima; Beate Vieth; Michael A. Murphy; Sean K. Simmons; Thomas Lefevre; Irene Claes; Christopher L. O’Connor; Rajasree Menon; Edgar A. Otto; Yoshinari Ando; Katy Vandereyken; Matthias Kretzler; Markus Bitzer; Ernest Fraenkel; Thierry Voet; Wolfgang Enard; Piero Carninci; Holger Heyn; Joshua Z. Levin; Elisabetta Mereu
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Integration of multiomic and multi-phenotypic data identifies biological pathways associated with physical fitness
errCommunications Biology
IF5.1
err2026-02-17
err0
errOAAI
errAzar Alizadeh; John Graf; Matthew J. Misner; Andrew A. Burns; Fiona Ginty; Kevin J. O’Donovan; J. Kenneth Wickiser; Nicholas Barringer; Gregory Freisinger; Neil Herm Hermansen; J. Elizabeth McDonough; Brian Davis; Evelina R. Loghin; Christine Surrette; Peter Tu; Justin Welch; Oliver Boomhower; Ralf Lenigk; Rachel Sorrell; Tyler Hammond; Sara Peterson; Alison Caron; Leila Safazadeh; Chrystal Chadwick; Stephanie Stacey; James Jobin; Scott C. Evans; Rui Xu; Gurvinder S. Khinda; Eric D. Williams; Swapnil Chhabra; Nhan Huynh; Taisha Joseh; Ernest Fraenkel; Luca Marinelli
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Corrigendum to “Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data”
errMolecular & Cellular Proteomics
IF5.5
err2025-08-07
err0
PREAI
errDušica Vidović; Behrouz Shamsaei; Stephan C. Schürer; Phillip Kogan; Szymon Chojnacki; Michal Kouril; Mario Medvedovic; Wen Niu; Evren U. Azeloglu; Marc R. Birtwistle; Yibang Chen; Tong Chen; Jens Hansen; Bin Hu; Ravi Iyengar; Gomathi Jayaraman; Hong Li; Tong Liu; Eric A. Sobie; Yuguang Xiong; Matthew J. Berberich; Gary Bradshaw; Mirra Chung; Robert A. Everley; Ben Gaudio; Marc Hafner; Marian Kalocsay; Caitlin E. Mills; Maulik K. Nariya; Peter K. Sorger; Kartik Subramanian; Chiara Victor; Maria Banuelos; Victoria Dardov; Ronald Holewinski; Danica-Mae Manalo; Berhan Mandefro; Andrea D. Matlock; Loren Ornelas; Dhruv Sareen; Clive N. Svendsen; Vineet Vaibhav; Jennifer E. Van Eyk; Vidya Venkatraman; Steve Finkbiener; Ernest Fraenkel; Jeffrey Rothstein; Leslie Thompson; Jacob Asiedu; Steven A. Carr; Karen E. Christianson; Desiree Davison; Deborah O. Dele-Oni; Katherine C. DeRuff; Shawn B. Egri; Alvaro Sebastian Vaca Jacome; Jacob D. Jaffe; Daniel Lam; Lev Litichevskiy; Xiaodong Lu; James Mullahoo; Adam Officer; Malvina Papanastasiou; Ryan Peckner; Caidin Toder; Joel Blanchard; Michael Bula; Tak Ko; Li-Huei Tsai; Jennie Z. Young; Vagisha Sharma; Jarek Meller; Michael J. MacCoss
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Listener effort measures clinically meaningful change of dysarthria in amyotrophic lateral sclerosis
errBrain Communications
IF4.5
err2025-06-12
err0
errOAAI
errIndu Navar Bingham; Raquel Norel; Esteban G Roitberg; Julián Peller; Marcos A Trevisan; Carla Agurto; Michele Merler; Diego E Shalom; Felipe Aguirre; Iair Embon; Alan Taitz; Donna Harris; Amy Wright; Katie Seaver; Stacey Sullivan; Jordan R Green; Lyle W Ostrow; Ernest Fraenkel; James D Berry
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Integration of transcriptomics, proteomics and loss-of-function screening reveals WEE1 as a target for combination with dasatinib against proneural glioblastoma
errCANCER LETTERS
IF10.1
err2024-11-01
err0
errOAAI
errAlhalabi, Obada T.; Goettmann, Mona; Gold, Maxwell P.; Schlue, Silja; Hielscher, Thomas; Iskar, Murat; Kessler, Tobias; Hai, Ling; Lokumcu, Tolga; Cousins, Clara C.; Herold-Mende, Christel; Hessling, Bernd; Horschitz, Sandra; Jabali, Ammar; Koch, Philipp; Baumgartner, Ulrich; Day, Bryan W.; Wick, Wolfgang; Sahm, Felix; Krieg, Sandro M.; Fraenkel, Ernest; Phillips, Emma; Goidts, Violaine
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Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson's disease
errMOLECULAR BRAIN
IF2.9
err2024-08-13
err4
errOAAI
errDehestani, Mohammad; Kozareva, Velina; Blauwendraat, Cornelis; Fraenkel, Ernest; Gasser, Thomas; Bansal, Vikas
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Targeting low levels of MIF expression as a potential therapeutic strategy for ALS
errCELL REPORTS MEDICINE
IF10.6
err2024-05-01
err2
errOAAI
errAlfahel, Leenor; Gschwendtberger, Thomas; Kozareva, Velina; Dumas, Laura; Gibbs, Rachel; Kertser, Alexander; Baruch, Kuti; Zaccai, Shir; Kahn, Joy; Thau-Habermann, Nadine; Eggenschwiler, Reto; Sterneckert, Jared; Hermann, Andreas; Sundararaman, Niveda; Vaibhav, Vineet; Van Eyk, Jennifer E.; Rafuse, Victor F.; Fraenkel, Ernest; Cantz, Tobias; Petri, Susanne; Israelson, Adrian
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Developmental basis of SHH medulloblastoma heterogeneity
errNATURE COMMUNICATIONS
IF15.7
err2024-01-08
err3
errOAAI
errGold, Maxwell P.; Ong, Winnie; Masteller, Andrew M.; Ghasemi, David R.; Galindo, Julie Anne; Park, Noel R.; Huynh, Nhan C.; Donde, Aneesh; Pister, Veronika; Saurez, Raul A.; Vladoiu, Maria C.; Hwang, Grace H.; Eisemann, Tanja; Donovan, Laura K.; Walker, Adam D.; Benetatos, Joseph; Dufour, Christelle; Garzia, Livia; Segal, Rosalind A.; Wechsler-Reya, Robert J.; Mesirov, Jill P.; Korshunov, Andrey; Pajtler, Kristian W.; Pomeroy, Scott L.; Ayrault, Olivier; Davidson, Shawn M.; Cotter, Jennifer A.; Taylor, Michael D.; Fraenkel, Ernest
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Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage
errNATURE COMMUNICATIONS
IF15.7
err2024-01-08
err0
errOAAI
errGhasemi, David R.; Okonechnikov, Konstantin; Rademacher, Anne; Tirier, Stephan; Maass, Kendra K.; Schumacher, Hanna; Joshi, Piyush; Gold, Maxwell P.; Sundheimer, Julia; Statz, Britta; Rifaioglu, Ahmet S.; Bauer, Katharina; Schumacher, Sabrina; Bortolomeazzi, Michele; Giangaspero, Felice; Ernst, Kati J.; Clifford, Steven C.; Saez-Rodriguez, Julio; Jones, David T. W.; Kawauchi, Daisuke; Fraenkel, Ernest; Mallm, Jan-Philipp; Rippe, Karsten; Korshunov, Andrey; Pfister, Stefan M.; Pajtler, Kristian W.
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Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma
errNATURE GENETICS
IF31.8
err2023-11-09
err8
errOAAI
errChapman, Owen S.; Luebeck, Jens; Sridhar, Sunita; Wong, Ivy Tsz-Lo; Dixit, Deobrat; Wang, Shanqing; Prasad, Gino; Rajkumar, Utkrisht; Pagadala, Meghana S.; Larson, Jon D.; He, Britney Jiayu; Hung, King L.; Lange, Joshua T.; Dehkordi, Siavash R.; Chandran, Sahaana; Adam, Miriam; Morgan, Ling; Wani, Sameena; Tiwari, Ashutosh; Guccione, Caitlin; Lin, Yingxi; Dutta, Aditi; Lo, Yan Yuen; Juarez, Edwin; Robinson, James T.; Korshunov, Andrey; Michaels, John-Edward A.; Cho, Yoon-Jae; Malicki, Denise M.; Coufal, Nicole G.; Levy, Michael L.; Hobbs, Charlotte; Scheuermann, Richard H.; Crawford, John R.; Pomeroy, Scott L.; Rich, Jeremy N.; Zhang, Xinlian; Chang, Howard Y.; Dixon, Jesse R.; Bagchi, Anindya; Deshpande, Aniruddha J.; Carter, Hannah; Fraenkel, Ernest; Mischel, Paul S.; Wechsler-Reya, Robert J.; Bafna, Vineet; Mesirov, Jill P.; Chavez, Lukas
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Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
errNATURE COMMUNICATIONS
IF15.7
err2023-11-03
err2
errOAAI
errNithianandam, Vanitha; Bukhari, Hassan; Leventhal, Matthew J.; Battaglia, Rachel A.; Dong, Xianjun; Fraenkel, Ernest; Feany, Mel B.
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Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2023-09-06
err9
errOAAI
errPeruzzi, Pierpaolo; Dominas, Christine; Fell, Geoffrey; Bernstock, Joshua D.; Blitz, Sarah; Mazzetti, Debora; Zdioruk, Mykola; Dawood, Hassan Y.; Triggs, Daniel V.; Ahn, Sebastian W.; Bhagavatula, Sharath K.; Davidson, Shawn M.; Tatarova, Zuzana; Pannell, Michael; Truman, Kyla; Ball, Anna; Gold, Maxwell P.; Pister, Veronika; Fraenkel, Ernest; Chiocca, E. Antonio; Ligon, Keith L.; Wen, Patrick Y.; Jonas, Oliver
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Adaptive bias correction for improved subseasonal forecasting
errNATURE COMMUNICATIONS
IF15.7
err2023-06-15
err11
errOAAI
errMouatadid, Soukayna; Orenstein, Paulo; Flaspohler, Genevieve; Cohen, Judah; Oprescu, Miruna; Fraenkel, Ernest; Mackey, Lester
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Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects
errNEURON
IF15
err2023-04-01
err28
errOAAI
errWorkman, Michael J.; Lim, Ryan G.; Wu, Jie; Frank, Aaron; Ornelas, Loren; Panther, Lindsay; Galvez, Erick; Perez, Daniel; Meepe, Imara; Lei, Susan; Valencia, Viviana; Gomez, Emilda; Liu, Chunyan; Moran, Ruby; Pinedo, Louis; Tsitkov, Stanislav; Ho, Ritchie; Kaye, Julia A.; Thompson, Terri; Rothstein, Jeffrey D.; Finkbeiner, Steven; Fraenkel, Ernest; Sareen, Dhruv; Thompson, Leslie M.; Svendsen, Clive N.
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Assembly of a functional beta interferon enhanceosome is dependent on ATF-2-c-jun heterodimer orientation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err137
errOAAI
errFalvo, JV; Parekh, BS; Lin, CH; Fraenkel, E; Maniatis, T
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Unbiased, Genome-Wide In Vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-Specific Liver Gene Expression
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err86
errOAAI
errLing, Guoyu; Sugathan, Aarathi; Mazor, Tali; Fraenkel, Ernest; Waxman, David J.
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Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation
errNATURE COMMUNICATIONS
IF15.7
err2022-12-21
err22
errOAAI
errLim, Ryan G.; Al-Dalahmah, Osama; Wu, Jie; Gold, Maxwell P.; Reidling, Jack C.; Tang, Guomei; Adam, Miriam; Dansu, David K.; Park, Hye-Jin; Casaccia, Patrizia; Miramontes, Ricardo; Reyes-Ortiz, Andrea M.; Lau, Alice; Hickman, Richard A.; Khan, Fatima; Paryani, Fahad; Tang, Alice; Ofori, Kenneth; Miyoshi, Emily; Michael, Neethu; McClure, Nicolette; Flowers, Xena E.; Vonsattel, Jean Paul; Davidson, Shawn; Menon, Vilas; Swarup, Vivek; Fraenkel, Ernest; Goldman, James E.; Thompson, Leslie M.
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A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses
errCOMMUNICATIONS BIOLOGY
IF5.1
err2022-10-07
err14
errOAAI
errGross, Sean M.; Dane, Mark A.; Smith, Rebecca L.; Devlin, Kaylyn L.; McLean, Ian C.; Derrick, Daniel S.; Mills, Caitlin E.; Subramanian, Kartik; London, Alexandra B.; Torre, Denis; Evangelista, John Erol; Clarke, Daniel J. B.; Xie, Zhuorui; Erdem, Cemal; Lyons, Nicholas; Natoli, Ted; Pessa, Sarah; Lu, Xiaodong; Mullahoo, James; Li, Jonathan; Adam, Miriam; Wassie, Brook; Liu, Moqing; Kilburn, David F.; Liby, Tiera A.; Bucher, Elmar; Sanchez-Aguila, Crystal; Daily, Kenneth; Omberg, Larsson; Wang, Yunguan; Jacobson, Connor; Yapp, Clarence; Chung, Mirra; Vidovic, Dusica; Lu, Yiling; Schurer, Stephan; Lee, Albert; Pillai, Ajay; Subramanian, Aravind; Papanastasiou, Malvina; Fraenkel, Ernest; Feiler, Heidi S.; Mills, Gordon B.; Jaffe, Jake D.; Ma'ayan, Avi; Birtwistle, Marc R.; Sorger, Peter K.; Korkola, James E.; Gray, Joe W.; Heiser, Laura M.
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Single cell metabolism: current and future trends
errMETABOLOMICS
IF3.3
err2022-10-01
err27
errOAAI
errAli, Ahmed; Davidson, Shawn; Fraenkel, Ernest; Gilmore, Ian; Hankemeier, Thomas; Kirwan, Jennifer A.; Lane, Andrew N.; Lanekoff, Ingela; Larion, Mioara; McCall, Laura-Isobel; Murphy, Michael; Sweedler, Jonathan V.; Zhu, Caigang
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Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data
errNATURE COMPUTATIONAL SCIENCE
IF18.3
err2022-09-08
err19
errOAAI
errRamamoorthy, Divya; Severson, Kristen; Ghosh, Soumya; Sachs, Karen; Glass, Jonathan D.; Fournier, Christina N.; Herrington, Todd M.; Berry, James D.; Ng, Kenney; Fraenkel, Ernest
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Research Directions

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Co-authors
Cooperation Journals
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H-index: 207 · Papers: 1.9K
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Paul Greengard
H-index: 206 · Papers: 1.1K
D
David A. Weitz
H-index: 181 · Papers: 1.3K
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