Not logged inSingle Cell Atlas of Follicular Lymphoma across Clinical Stages Defines Tumor B Cell Archetypes, Immune Microenvironment Heterogeneity and Novel Cell States Associated with High-Risk FL
Sarrabay, Alexandre; Baaklini, Sabrina; Barthelemy, Camille; Gil, Laurine; Beyou, Alicia; Dahbi, Laila; Mossadegh-Keller, Noushin; Huber, Caroline; Navarro, Jean-Marc; Salles, Gilles; Brisou, Gabriel; Estevez, Maria Ortiz; Stokes, Matthew E.; Seth, Sahil; Huang, C. Chris; Kaplan, Mark; Spinelli, Lionel; Gandhi, Anita K.; Nadel, Bertrand; Milpied, Pierre; Roulland, Sandrine .png)
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SavePhase 2 study of neoadjuvant enzalutamide and paclitaxel for luminal androgen receptor-enriched TNBC: Trial results and insights into ARness ''Lim, Bora; Seth, Sahil; Yam, Clinton; Huo, Lei; Fujii, Takeo; Lee, Jangsoon; Bassett, Roland; Nasser, Sara; Ravenberg, Lisa; White, Jason; Clayborn, Alyson; Guerra, Gil; Litton, Jennifer K.; Damodaran, Senthil; Layman, Rachel; Valero, Vicente; Tripathy, Debasish; Lewis, Michael; Dobrolecki, Lacey E.; Lei, Jonathan; Candelaria, Rosalind; Arun, Banu; Rauch, Gaiane; Zhao, Li; Zhang, Jianhua; Ding, Qingqing; Symmans, W. Fraser; Chang, Jeffrey T.; Thompson, Alastair M.; Moulder, Stacy L.; Ueno, Naoto T. Share Save PTEN in triple-negative breast carcinoma: protein expression and genomic alteration in pretreatment and posttreatment specimensChen, Hui; Ding, Qingqing; Khazai, Laila; Zhao, Li; Damodaran, Senthil; Litton, Jennifer K.; Rauch, Gaiane M.; Yam, Clinton; Chang, Jeffrey T.; Seth, Sahil; Lim, Bora; Thompson, Alastair M.; Mittendorf, Elizabeth A.; Adrada, Beatriz; Virani, Kiran; White, Jason B.; Ravenberg, Elizabeth; Song, Xingzhi; Candelaria, Rosalind; Arun, Banu; Ueno, Naoto T.; Santiago, Lumarie; Saleem, Sadia; Abouharb, Sausan; Murthy, Rashmi K.; Ibrahim, Nuhad; Routbort, Mark J.; Sahin, Aysegul; Valero, Vicente; Symmans, William Fraser; Tripathy, Debu; Wang, Wei-Lien; Moulder, Stacy; Huo, Lei Share Save A functional genomic approach to actionable gene fusions for precision oncologyLi, Jun; Lu, Hengyu; Ng, Patrick Kwok-Shing; Pantazi, Angeliki; Ip, Carman Ka Man; Jeong, Kang Jin; Amador, Bianca; Tran, Richard; Tsang, Yiu Huen; Yang, Lixing; Song, Xingzhi; Dogruluk, Turgut; Ren, Xiaojia; Hadjipanayis, Angela; Bristow, Christopher A.; Lee, Semin; Kucherlapati, Melanie; Parfenov, Michael; Tang, Jiabin; Seth, Sahil; Mahadeshwar, Harshad S.; Mojumdar, Kamalika; Zeng, Dong; Zhang, Jianhua; Protopopov, Alexei; Seidman, Jonathan G.; Creighton, Chad J.; Lu, Yiling; Sahni, Nidhi; Shaw, Kenna R.; Meric-Bernstam, Funda; Futreal, Andrew; Chin, Lynda; Scott, Kenneth L.; Kucherlapati, Raju; Mills, Gordon B.; Liang, Han Share Save Share Save Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of functionKumar, Manish; Molkentine, David; Molkentine, Jessica; Bridges, Kathleen; Xie, Tongxin; Yang, Liangpeng; Hefner, Andrew; Gao, Meng; Bahri, Reshub; Dhawan, Annika; Frederick, Mitchell J.; Seth, Sahil; Abdelhakiem, Mohamed; Beadle, Beth M.; Johnson, Faye; Wang, Jing; Shen, Li; Heffernan, Timothy; Sheth, Aakash; Ferris, Robert L.; Myers, Jeffrey N.; Pickering, Curtis R.; Skinner, Heath D. Share Save Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal CancerInoue, Akira; Robinson, Frederick S.; Minelli, Rosalba; Tomihara, Hideo; Rizi, Bahar Salimian; Rose, Johnathon L.; Kodama, Takahiro; Srinivasan, Sanjana; Harris, Angela L.; Zuniga, Andy M.; Mullinax, Robert A.; Ma, Xiaoyan; Seth, Sahil; Daniele, Joseph R.; Peoples, Michael D.; Loponte, Sara; Akdemir, Kadir C.; Khor, Tin Oo; Feng, Ningping; Roszik, Jason; Sobieski, Mary M.; Brunell, David; Stephan, Clifford; Giuliani, Virginia; Deem, Angela K.; Shingu, Takashi; Deribe, Yonathan Lissanu; Menter, David G.; Heffernan, Timothy P.; Viale, Andrea; Bristow, Christopher A.; Kopetz, Scott; Draetta, Giulio F.; Genovese, Giannicola; Carugo, Alessandro Share Save Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in GlioblastomaPuca, Francesca; Yu, Fei; Bartolacci, Caterina; Pettazzoni, Piergiorgio; Carugo, Alessandro; Huang-Hobbs, Emmet; Liu, Jintan; Zanca, Ciro; Carbone, Federica; Del Poggetto, Edoardo; Gumin, Joy; Dasgupta, Pushan; Seth, Sahil; Srinivasan, Sanjana; Lang, Frederick F.; Sulman, Erik P.; Lorenzi, Philip L.; Tan, Lin; Shan, Mengrou; Tolstyka, Zachary P.; Kachman, Maureen; Zhang, Li; Gao, Sisi; Deem, Angela K.; Genovese, Giannicola; Scaglioni, Pier Paolo; Lyssiotis, Costas A.; Viale, Andrea; Draetta, Giulio F. Share Save Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward OsimertinibSun, Yuting; Meyers, Brooke A.; Czako, Barbara; Leonard, Paul; Mseeh, Faika; Harris, Angela L.; Wu, Qi; Johnson, Sarah; Parker, Connor A.; Cross, Jason B.; Di Francesco, Maria Emilia; Bivona, Benjamin J.; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gao, Guang; Gera, Sonal; Giuliani, Virginia; Huang, Justin K.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Liu, Chiu-Yi; Lopez, Anastasia M.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Miller, Meredith A.; Mullinax, Robert A.; Peoples, Michael; Ramamoorthy, Vandhana; Seth, Sahil; Spencer, Nakia D.; Suzuki, Erika; Williams, Christopher C.; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structureAkdemir, Kadir C.; Le, Victoria T.; Kim, Justin M.; Killcoyne, Sarah; King, Devin A.; Lin, Ya-Ping; Tian, Yanyan; Inoue, Akira; Amin, Samirkumar B.; Robinson, Frederick S.; Nimmakayalu, Manjunath; Herrera, Rafael E.; Lynn, Erica J.; Chan, Kin; Seth, Sahil; Klimczak, Leszek J.; Gerstung, Moritz; Gordenin, Dmitry A.; O'Brien, John; Li, Lei; Deribe, Yonathan Lissanu; Verhaak, Roel G.; Campbell, Peter J.; Fitzgerald, Rebecca; Morrison, Ashby J.; Dixon, Jesse R.; Andrew Futreal, P. Share Save Longitudinal response and selection under neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized, TNBC enrolling trial to confirm molecular profiling improves survival (ARTEMIS; NCT02276443)Seth, Sahil; Huo, Lei; Vasaikar, Suhas; Rauch, Gaiane; Lim, Bora; White, Jason; Adrada, Beatriz; Piwnica-Worms, Helen; Ueno, Naoto T.; Thompson, Alastair Mark; Mittendorf, Elizabeth; Tripathy, Debashish; Litton, Jennifer Keating; Symmans, William Fraser; Draetta, Giulio; Futreal, Andrew; Chang, Jeffrey; Moulder, Stacy Share Save Discovery of IACS-13909, an allosteric SHP2 inhibitor that overcomes multiple mechanisms underlying osimertinib resistanceSun, Yuting; Meyers, Brooke A.; Johnson, Sarah B.; Harris, Angela L.; Czako, Barbara; Cross, Jason B.; Leonard, Paul G.; Mseeh, Faika; Di Francesco, Maria E.; Parker, Connor A.; Wu, Qi; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gera, Sonal; Guang, Gao; Huang, Justin Kwang-Lay; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Mullinax, Robert A.; Peoples, Michael D.; Ramamoorthy, Vandhana; Seth, Sahil; Suzuki, Erika; Williams, Christopher Conrad; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save Global impact of somatic structural variation on the DNA methylome of human cancersZhang, Yiqun; Yang, Lixing; Kucherlapati, Melanie; Hadjipanayis, Angela; Pantazi, Angeliki; Bristow, Christopher A.; Lee, Eunjung Alice; Mahadeshwar, Harshad S.; Tang, Jiabin; Zhang, Jianhua; Seth, Sahil; Lee, Semin; Ren, Xiaojia; Song, Xingzhi; Sun, Huandong; Seidman, Jonathan; Luquette, Lovelace J.; Xi, Ruibin; Chin, Lynda; Protopopov, Alexei; Park, Peter J.; Kucherlapati, Raju; Creighton, Chad J. Share Save Targeting histone acetyltransferase (HAT) function for synthetic cytotoxicity in CREBBP/EP300 mutant tumorsPickering, Curtis; Kumar, Manish; Bridges, Kathleen; Xie, Tongxin; Molkentine, David; Sheth, Aakash; Yang, Liang; Frederick, Mitchell; Heffernan, Tim; Seth, Sahil; Myers, Jeffrey; Skinner, Heath D. Share Save Dissection of clonal heterogeneity unmasks pre-existing chemoresistance and new metabolic vulnerabilities in pancreatic cancerSeth, Sahil; Li, Chieh-Yuan; Loponte, Sara; Ho, I-Lin; Corti, Denise; Sapio, Luigi; Del Poggetto, Edoardo; Peoples, Michael; Karpinets, Tatiana; Robinson, Frederick S.; Jiang, Shan; Dutta, Prasanta; Marszalek, Joseph; Di Francesco, Maria E.; Heffernan, Timothy P.; Giuliani, Virginia; Bhattacharya, Pratip K.; Genovese, Giannicola; Futreal, Andrew; Draetta, Giulio; Viale, Andrea; Carugo, Alessandro Share Save Clonal dynamics and phenotypic evolution during chemoresistance and metastasis revealed by patient-derived xenograft models of triple negative breast cancerEcheverria, Gloria V.; Ge, Zhongqi; Seth, Sahil; Powell, Emily; Zhang, Xiaomei; Jeter-Jones, Sabrina; Zhou, Xinhui; Jiang, Yan; McCoy, Aaron; Cai, Shirong; Tu, Yizheng; Peoples, Michael; Sun, Yuting; Qiu, Huan; Bristow, Christopher; Carugo, Alessandro; Shao, Jiansu; Moulder, Stacy L.; Symmans, William F.; Heffernan, Timothy P.; Chang, Jeffrey T.; Piwnica-Worms, Helen M. Share Save Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant stateEcheverria, Gloria V.; Ge, Zhongqi; Seth, Sahil; Zhang, Xiaomei; Jeter-Jones, Sabrina; Zhou, Xinhui; Cai, Shirong; Tu, Yizheng; McCoy, Aaron; Peoples, Michael; Sun, Yuting; Qiu, Huan; Chang, Qing; Bristow, Christopher; Carugo, Alessandro; Shao, Jiansu; Ma, Xiaoyan; Harris, Angela; Mundi, Prabhjot; Lau, Rosanna; Ramamoorthy, Vandhana; Wu, Yun; Alvarez, Mariano J.; Califano, Andrea; Moulder, Stacy L.; Symmans, William F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Chang, Jeffrey T.; Piwnica-Worms, Helen Share Save Resistance to neoadjuvant chemotherapy in triple negative breast cancer mediated by a reversible drug-tolerant stateEcheverria, G. V.; Ge, Z.; Seth, S.; Jeter-Jones, S. L.; Zhang, X.; Zhou, X.; Cai, S.; Tu, Y.; Mccoy, A.; Peoples, M.; Lau, R.; Shao, J.; Sun, Y.; Bristow, C.; Carugo, A.; Ma, X.; Harris, A.; Wu, Y.; Moulder, S.; Symmans, W. F.; Marszalek, J. R.; Heffernan, T. P.; Chang, J. T.; Piwnica-Worms, H. Share Save Towards a therapeutically relevant subtyping scheme for triple-negative breast cancer (TNBC), profiling results from A Randomized, TNBC Enrolling trial to confirm Molecular profiling Improves Survival (ARTEMIS)Seth, S.; Huo, L.; Rauch, G.; Lau, R.; Gilcrease, M.; Adrada, B.; Piwnica-Worms, H.; Symmans, W. F.; Draetta, G.; Futreal, A. P.; Moulder, S.; Chang, J. T. Share Save Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic TumorsSeth, Sahil; Li, Chieh-Yuan; Ho, I-Lin; Corti, Denise; Loponte, Sara; Sapio, Luigi; Del Poggetto, Edoardo; Yen, Er-Yen; Robinson, Frederick Scott; Peoples, Michael; Karpinets, Tatiana; Deem, Angela Kay; Kumar, Tapsi; Song, Xingzhi; Jiang, Shan; Kang, Ya'an; Fleming, Jason; Kim, Michael; Zhang, Jianhua; Maitra, Anirban; Heffernan, Timothy Paul; Giuliani, Virginia; Genovese, Giannicola; Futreal, Andrew; Draetta, Giulio Francesco; Carugo, Alessandro; Viale, Andrea Share Save 
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