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Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma Marasco, Michelangelo; Kumar, Dinesh; Seale, Tessa; Borrego, Santiago Garcia; Kaplun, Esther; Aricescu, Ilinca; Cole, Soren; Qeriqi, Besnik; Qiu, Juan; Chen, Xiaoping; Bahr, Amber; Fidele, Deborah; Hofmann, Marco H.; Gerlach, Daniel; Savarese, Fabio; Merghoub, Taha; Wolchok, Jedd D.; Yao, Zhan; de Stanchina, Elisa; Solit, David; Misale, Sandra; Rosen, Neal Share Save
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harboring KRASG12V mutations and KRAS wild-type amplifications Tedeschi, A.; Peng, D. H.; Schischlik-Siegl, F.; Schaaf, O.; Gerlach, D.; Rocchetti, F.; Popow, J.; Broeker, J.; Wunberg, T.; Boghossian, A. S.; Rees, M. G.; Ronan, M. M.; Roth, J. A.; Williams, M.; Vellano, C.; Marszalek, J. R.; Heffernan, T. P.; Pearson, M.; Kraut, N.; Dorothea, R. Share Save
Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules Gollner, Andreas; Rudolph, Dorothea; Weyer-Czernilofsky, Ulrike; Baumgartinger, Rosa; Jung, Peter; Weinstabl, Harald; Ramharter, Jurgen; Grempler, Rolf; Quant, Jens; Rinnenthal, Jorg; Pitarch, Alejandro Perez; Golubovic, Bojana; Gerlach, Daniel; Bader, Gerd; Wetzel, Kristiane; Otto, Sebastian; Mandl, Christian; Boehmelt, Guido; Mcconnell, Darryl B.; Kraut, Norbert; Sini, Patrizia Share Save
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance Thatikonda, Venu; Lyu, Hengyu; Jurado, Sabine; Kostyrko, Kaja; Bristow, Christopher A.; Albrecht, Christoph; Alpar, Donat; Arnhof, Heribert; Bergner, Oliver; Bosch, Karin; Feng, Ningping; Gao, Sisi; Gerlach, Daniel; Gmachl, Michael; Hinkel, Melanie; Lieb, Simone; Jeschko, Astrid; Machado, Annette A.; Madensky, Thomas; Marszalek, Ethan D.; Mahendra, Mikhila; Melo-Zainzinger, Gabriella; Molkentine, Jessica M.; Jaeger, Philipp A.; Peng, David H.; Schenk, Robyn L.; Sorokin, Alexey; Strauss, Sandra; Trapani, Francesca; Kopetz, Scott; Vellano, Christopher P.; Petronczki, Mark; Kraut, Norbert; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; Waizenegger, Irene C.; Hofmann, Marco H. Share Save
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications Tedeschi, Antonio; Peng, David H.; Schischlik, Fiorella; Herdeis, Lorenz; Schaaf, Otmar; Santoro, Valeria; Gerlach, Daniel; Savarese, Fabio; Lipp, Jesse; Haslinger, Christian; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunber, Tobias; Gmachl, Michael; Rumpel, Klaus; Rees, Matthew; Ron, Melissa; Roth, Jennifer; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer Sale, Matthew J.; Mukherjee, Neal; Koch, Martin; Ruzicka, Regina; Jacob, Robin; Albrecht, Christoph; Zanin, Teresa; Madensky, Thomas; Schenk, Robyn L.; Baum, Anke; Kostyrko, Kaja; Gerlach, Daniel; Hofmann, Marco H.; McCormick, Frank Share Save
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Development and characterisation of KRASmulti inhibitors for the treatment of KRAS mutant pancreatic ductal adenocarcinoma Tedeschi, Antonio; Schaaf, Otmar; Gmachl, Michael; Herdeis, Lorenz; Rocchetti, Francesca; Popow, Johannes; Schischlik, Fiorella; Gerlach, Daniel; Lipp, Jesse; Broker, Joachim; Mantoulidis, Andreas; Smethurst, Chris; Kessler, Dirk; Boettcher, Jark; Wunberg, Tobias; Santoro, Valeria; Waterson, Alex; Phan, Jason; Little, Andrew; Abbott, Jason; Sun, Qi; Fesik, Stephen; Mcconnell, Darryl; Pearson, Mark A.; Kraut, Norbert; Rudolph, Dorothea Share Save
Determinants of sensitivity to BI KRASmulti inhibitor using high-throughput in-vitro drug screens Schischlik, Fiorella; Tedeschi, Antonio; Rudolph, Dorothea; Gerlach, Daniel; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Herdeis, Lorenz; Broeker, Joachim; Wunberg, Tobias; Boghossian, Andrew S.; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Haslinger, Christian; Lipp, Jesse Share Save
Molecular basis of GDF15 induction and suppression by drugs in cardiomyocytes and cancer cells toward precision medicine Winter, Lisa-Maria; Reinhardt, Diana; Schatter, Ariane; Tissen, Vivien; Wiora, Heike; Gerlach, Daniel; Tontsch-Grunt, Ulrike; Colbatzky, Florian; Stierstorfer, Birgit; Yun, Seong-Wook Share Save
SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer Sale, Matthew J.; Mukherjee, Neal; Ruzicka, Regina; Jacob, Robin; Albrecht, Christoph; Zanin, Teresa; Madensky, Tom; Kostyrko, Kaja; Schenk, Robyn L.; Baum, Anke; Gerlach, Daniel; Hofmann, Marco H.; McCormick, Frank Share Save
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling Wilding, Birgit; Scharn, Dirk; Boese, Dietrich; Baum, Anke; Santoro, Valeria; Chetta, Paolo; Schnitzer, Renate; Botesteanu, Dana A.; Reiser, Christoph; Kornigg, Stefan; Knesl, Petr; Hoermann, Alexandra; Koeferle, Anna; Corcokovic, Maja; Lieb, Simone; Scholz, Guido; Bruchhaus, Jens; Spina, Markus; Balla, Josef; Peric-Simov, Biljana; Zimmer, Jasmin; Mitzner, Sophie; Fett, Thomas N.; Beran, Alexandra; Lamarre, Lyne; Gerstberger, Thomas; Gerlach, Daniel; Bauer, Markus; Bergner, Andreas; Schlattl, Andreas; Bader, Gerd; Treu, Matthias; Engelhardt, Harald; Zahn, Stephan; Fuchs, Julian E.; Zuber, Johannes; Ettmayer, Peter; Pearson, Mark; Petronczki, Mark; Kraut, Norbert; McConnell, Darryl B.; Solca, Flavio; Neumuller, Ralph A. Share Save
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BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition Hofmann, Marco H.; Gmachl, Michael; Ramharter, Juergen; Savarese, Fabio; Gerlach, Daniel; Marszalek, Joseph R.; Sanderson, Michael P.; Kessler, Dirk; Trapani, Francesca; Arnhof, Heribert; Rumpel, Klaus; Botesteanu, Dana-Adriana; Ettmayer, Peter; Gerstberger, Thomas; Kofink, Christiane; Wunberg, Tobias; Zoephel, Andreas; Fu, Szu-Chin; Teh, Jessica L.; Boettcher, Jark; Pototschnig, Nikolai; Schachinger, Franziska; Schipany, Katharina; Lieb, Simone; Vellano, Christopher P.; O'Connell, Jonathan C.; Mendes, Rachel L.; Moll, Jurgen; Petronczki, Mark; Heffernan, Timothy P.; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert Share Save
CLIFF, a bioinformatics software tool to explore molecular differences between two sets of cancer cell lines Wernitznig, Andreas; Lipp, Jesse J.; Zichner, Thomas; Gerlach, Daniel; Bauer, Markus J.; Voss, Tilman; Schlattl, Andreas; Haslinger, Christian; Montgomery, Philip G.; Zamanighomi, Mahdi; Sellers, William R.; Kraut, Norbert Share Save
BI-3406 and BI 1701963: Potent and selective SOS1::KRAS inhibitors induce regressions in combination with MEK inhibitors or irinotecan Gerlach, Daniel; Gmachl, Michael; Ramharter, Juergen; Teh, Jessica; Fu, Szu-Chin; Trapani, Francesca; Kessler, Dirk; Rumpel, Klaus; Botesteanu, Dana-Adriana; Ettmayer, Peter; Arnhof, Heribert; Gerstberger, Thomas; Kofink, Christiane; Wunberg, Tobias; Vellano, Christopher P.; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert; Hofmann, Marco H. Share Save
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