Not logged in A landscape of response to drug combinations in non-small cell lung cancer Nair, Nishanth Ulhas; Greninger, Patricia; Zhang, Xiaohu; Friedman, Adam A.; Amzallag, Arnaud; Cortez, Eliane; Sahu, Avinash Das; Lee, Joo Sang; Dastur, Anahita; Egan, Regina K.; Murchie, Ellen; Ceribelli, Michele; Crowther, Giovanna S.; Beck, Erin; McClanaghan, Joseph; Klump-Thomas, Carleen; Boisvert, Jessica L.; Damon, Leah J.; Wilson, Kelli M.; Ho, Jeffrey; Tam, Angela; McKnight, Crystal; Michael, Sam; Itkin, Zina; Garnett, Mathew J.; Engelman, Jeffrey A.; Haber, Daniel A.; Thomas, Craig J.; Ruppin, Eytan; Benes, Cyril H. Share Save
Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension Tam, Angela Y. Y.; Horwell, Amy L.; Trinder, Sarah L.; Khan, Korsa; Xu, Shiwen; Ong, Voon; Denton, Christopher P.; Norman, Jill T.; Holmes, Alan M.; Bou-Gharios, George; Abraham, David J. Share Save
PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies Sheng, Qing; D'Alessio, Joseph A.; Menezes, Daniel L.; Karim, Christopher; Tang, Yan; Tam, Angela; Clark, Suzanna; Ying, Chi; Connor, Anu; Mansfield, Keith G.; Rondeau, Jean-Michel; Ghoddusi, Majid; Geyer, Felipe C.; Gu, Jane; McLaughlin, Margaret E.; Newcombe, Rick; Elliot, GiNell; Tschantz, William R.; Lehmann, Sylvie; Fanton, Christie P.; Miller, Kathy; Huber, Thomas; Rendahl, Katherine G.; Jeffry, Ursula; Pryer, Nancy K.; Lees, Emma; Kwon, Paul; Abraham, Judith A.; Damiano, Jason S.; Abrams, Tinya J. Share Save
Using genome-wide CRISPR screen to understand resistance mechanisms to PCA062, a P-cadherin targeting antibody-drug conjugate Tam, Angela; Zambrowski, Mark; Seiss, Katherine; Liu, Si-Qi; Abrams, Tinya; Caponigro, Giordano; Tschantz, William; Campbell, Jennifer; DAlessio, Tony; Sheng, Qing Share Save
Differential responses of MET activations to MET kinase inhibitor and neutralizing antibody Kou, Jianqun; Musich, Phillip R.; Staal, Ben; Kang, Liang; Qin, Yuan; Yao, Zhi Q.; Zhang, Boheng; Wu, Weizhong; Tam, Angela; Huang, Alan; Hao, Huai-Xiang; Vande Woude, George F.; Xie, Qian Share Save
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation Ferraro, Gino B.; Kodack, David P.; Askoxylakis, Vasileios; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Alexander Z.; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Youngchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, Ryan C.; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Valeria M.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation Kodack, David P.; Askoxylakis, Vasileios; Ferraro, Gino B.; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Z. Alexander; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Yongchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina S. F.; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, C. Ryan; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Monica V.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save
Spatial heterogeneity in medulloblastoma Morrissy, A. Sorana; Cavalli, Florence M. G.; Remke, Marc; Ramaswamy, Vijay; Shih, David J. H.; Holgado, Borja L.; Farooq, Hamza; Donovan, Laura K.; Garzia, Livia; Agnihotri, Sameer; Kiehna, Erin N.; Mercier, Eloi; Mayoh, Chelsea; Papillon-Cavanagh, Simon; Nikbakht, Hamid; Gayden, Tenzin; Torchia, Jonathon; Picard, Daniel; Merino, Diana M.; Vladoiu, Maria; Luu, Betty; Wu, Xiaochong; Daniels, Craig; Horswell, Stuart; Thompson, Yuan Yao; Hovestadt, Volker; Northcott, Paul A.; Jones, David T. W.; Peacock, John; Wang, Xin; Mack, Stephen C.; Reimand, Juri; Albrecht, Steffen; Fontebasso, Adam M.; Thiessen, Nina; Li, Yisu; Schein, Jacqueline E.; Lee, Darlene; Carlsen, Rebecca; Mayo, Michael; Tse, Kane; Tam, Angela; Dhalla, Noreen; Ally, Adrian; Chuah, Eric; Cheng, Young; Plettner, Patrick; Li, Haiyan I.; Corbett, Richard D.; Wong, Tina; Long, William; Loukides, James; Buczkowicz, Pawel; Hawkins, Cynthia E.; Tabori, Uri; Rood, Brian R.; Myseros, John S.; Packer, Roger J.; Korshunov, Andrey; Lichter, Peter; Kool, Marcel; Pfister, Stefan M.; Schueller, Ulrich; Dirks, Peter; Huang, Annie; Bouffet, Eric; Rutka, James T.; Bader, Gary D.; Swanton, Charles; Ma, Yusanne; Moore, Richard A.; Mungall, Andrew J.; Majewski, Jacek; Jones, Steven J. M.; Das, Sunit; Malkin, David; Jabado, Nada; Marra, Marco A.; Taylor, Michael D. Share Save
High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells Horn, Thomas; Ferretti, Stephane; Ebel, Nicolas; Tam, Angela; Ho, Samuel; Harbinski, Fred; Farsidjani, Ali; Zubrowski, Matthew; Sellers, William R.; Schlegel, Robert; Porter, Dale; Morris, Erick; Wuerthner, Jens; Jeay, Sebastien; Greshock, Joel; Halilovic, Ensar; Garraway, Levi A.; Caponigro, Giordano; Lehar, Joseph Share Save
High order drug combinations are required to effectively kill colorectal cancer cells Horn, Thomas; Ferretti, Stephane; Ebel, Nicolas; Tam, Angela; Ho, Samuel; Harbinski, Fred; Farsidjani, Ali; Zubrowski, Matt; Sellers, William R.; Schlegel, Robert; Porter, Dale; Morris, Erick; Wuerthner, Jens; Jeay, Sebastien; Greshock, Joel; Halilovic, Ensar; Garraway, Levi A.; Caponigro, Giordano; Lehar, Joseph Share Save
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas Brat, Daniel J.; Verhaak, Roel G. W.; Al-dape, Kenneth D.; Yung, W. K. Alfred; Salama, Sofie R.; Cooper, Lee A. D.; Rheinbay, Esther; Miller, C. Ryan; Vitucci, Mark; Morozova, Olena; Robertson, A. Gordon; Noushmehr, Houtan; Laird, Peter W.; Cherniack, Andrew D.; Akbani, Rehan; Huse, Jason T.; Ciriello, Giovanni; Poisson, Laila M.; Barnholtz-Sloan, Jill S.; Berger, Mitchel S.; Brennan, Cameron; Colen, Rivka R.; Colman, Howard; Flanders, Adam E.; Giannini, Caterina; Grifford, Mia; Iavarone, Antonio; Jain, Rajan; Joseph, Isaac; Kim, Jaegil; Kasaian, Katayoon; Mikkelsen, Tom; Murray, Bradley A.; O'Neill, Brian Patrick; Pachter, Lior; Parsons, Donald W.; Sougnez, Carrie; Sulman, Erik P.; Vandenberg, Scott R.; Van Meir, Erwin G.; von Deimling, Andreas; Zhang, Hailei; Crain, Daniel; Lau, Kevin; Mallery, David; Morris, Scott; Paulauskis, Joseph; Penny, Robert; Shelton, Troy; Sherman, Mark; Yena, Peggy; Black, Aaron; Bowen, Jay; Dicostanzo, Katie; Gastier-Foster, Julie; Leraas, Kristen M.; Lichtenberg, Tara M.; Pierson, Christopher R.; Ramirez, Nilsa C.; Taylor, Cynthia; Weaver, Stephanie; Wise, Lisa; Zmuda, Erik; Davidsen, Tanja; Demchok, John A.; Eley, Greg; Ferguson, Martin L.; Hutter, Carolyn M.; Shaw, Kenna R. Mills; Ozenberger, Bradley A.; Sheth, Margi; Sofia, Heidi J.; Tarnuzzer, Roy; Wang, Zhining; Yang, Liming; Zenklusen, Jean Claude; Ayala, Brenda; Baboud, Julien; Chudamani, Sudha; Jensen, Mark A.; Liu, Jia; Pihl, Todd; Raman, Rohini; Wan, Yunhu; Wu, Ye; Ally, Adrian; Auman, J. Todd; Balasundaram, Miruna; Balu, Saianand; Baylin, Stephen B.; Beroukhim, Rameen; Bootwalla, Moiz S.; Bowlby, Reanne; Bristow, Christopher A.; Brooks, Denise; Butterfield, Yaron; Carlsen, Rebecca; Carter, Scott; Chin, Lynda; Chu, Andy; Chuah, Eric; Cibulskis, Kristian; Clarke, Amanda; Coetzee, Simon G.; Dhalla, Noreen; Fennell, Tim; Fisher, Sheila; Gabriel, Stacey; Getz, Gad; Gibbs, Richard; Guin, Ranabir; Hadjipanayis, Angela; Hayes, Neil; Hinoue, Toshinori; Hoadley, Katherine; Holt, Robert A.; Hoyle, Alan P.; Jefferys, Stuart R.; Jones, Steven; Jones, Corbin D.; Kucherlapati, Raju; Lai, Phillip H.; Lander, Eric; Lee, Semin; Lichtenstein, Lee; Ma, Yussanne; Maglinte, Dennis T.; Mahadeshwar, Harshad S.; Marra, Marco A.; Mayo, Michael; Meng, Shaowu; Meyerson, Matthew L.; Mieczkowski, Piotr A.; Moore, Richard A.; Mose, Lisle E.; Mungall, Andrew J.; Pantazi, Angeliki; Parfenov, Michael; Park, Peter J.; Parker, Joel S.; Perou, Charles M.; Proto-Popov, Alexei; Ren, Xiaojia; Roach, Jeffrey; Sabedot, Thas S.; Schein, Jacqueline; Schumacher, Steven E.; Seidman, Jonathan G.; Seth, Sahil; Shen, Hui; Simons, Janae V.; Sipahimalani, Payal; Soloway, Matthew G.; Song, Xingzhi; Sun, Huandong; Tabak, Barbara; Tam, Angela; Tan, Donghui; Tang, Jiabin; Thiessen, Nina; Triche, Timothy, Jr.; Van Den Berg, David J.; Veluvolu, Umadevi; Waring, Scot; Weisenberger, Daniel J.; Wilkerson, Matthew D.; Wong, Tina; Wu, Junyuan; Xi, Liu; Xu, Andrew W.; Yang, Lixing; Zack, Travis I.; Zhang, Jianhua; Aksoy, B. Arman; Arachchi, Harindra; Benz, Chris; Bernard, Brady; Carlin, Daniel; Cho, Juok; DiCara, Daniel; Frazer, Scott; Fuller, Gregory N.; Gao, JianJiong; Gehlenborg, Nils; Haussler, David; Heiman, David I.; Iype, Lisa; Jacobsen, Anders; Ju, Zhenlin; Katzman, Sol; Kim, Hoon; Knijnenburg, Theo; Kreisberg, Richard Bailey; Lawrence, Michael S.; Lee, William; Leinonen, Kalle; Lin, Pei; Ling, Shiyun; Liu, Wenbin; Liu, Yingchun; Liu, Yuexin; Lu, Yiling; Mills, Gordon; Ng, Sam; Noble, Michael S.; Paull, Evan; Rao, Arvind; Reynolds, Sheila; Saksena, Gordon; Sanborn, Zack; Sander, Chris; Schultz, Nikolaus; Senbabaoglu, Yasin; Shen, Ronglai; Shmulevich, Ilya; Sinha, Rileen; Stuart, Josh; Sumer, Onur; Sun, Yichao; Tasman, Natalie; Taylor, Barry S.; Voet, Doug; Weinhold, Nils; Weinstein, John N.; Yang, Da; Yoshihara, Kosuke; Zheng, Siyuan; Zhang, Wei; Zou, Lihua; Abel, Ty; Sadeghi, Sara; Cohen, Mark L.; Eschbacher, Jenny; Hattab, Eyas M.; Raghunathan, Aditya; Schniederjan, Matthew J.; Aziz, Dina; Barnett, Gene; Barrett, Wendi; Bigner, Darell D.; Boice, Lori; Brewer, Cathy; Calatozzolo, Chiara; Campos, Benito; Carlotti, Carlos Gilberto, Jr.; Chan, Timothy A.; Cuppini, Lucia; Curley, Erin; Cuzzubbo, Stefania; Devine, Karen; DiMeco, Francesco; Duell, Rebecca; Elder, J. Bradley; Fehrenbach, Ashley; Finocchiaro, Gaetano; Friedman, William; Fulop, Jordonna; Gardner, Johanna; Hermes, Beth; Herold-Mende, Christel; Jungk, Christine; Kendler, Ady; Lehman, Norman L.; Lipp, Eric; Liu, Ouida; Mandt, Randy; McGraw, Mary; Mclendon, Roger; McPherson, Christopher; Neder, Luciano; Nguyen, Phuong; Noss, Ardene; Nunziata, Raffaele; Ostrom, Quinn T.; Palmer, Cheryl; Perin, Alessandro; Pollo, Bianca; Potapov, Alexander; Potapova, Olga; Rathmell, W. Kimryn; Rotin, Daniil; Scarpace, Lisa; Schilero, Cathy; Senecal, Kelly; Shimmel, Kristen; Shurkhay, Vsevolod; Sifri, Suzanne; Singh, Rosy; Sloan, Andrew E.; Smolenski, Kathy; Staugaitis, Susan M.; Steele, Ruth; Thorne, Leigh; Tirapelli, Daniela P. C.; Unterberg, Andreas; Vallurupalli, Mahitha; Wang, Yun; Warnick, Ronald; Williams, Felicia; Wolinsky, Yingli; Bell, Sue; Rosenberg, Mara; Stewart, Chip; Huang, Franklin; Grimsby, Jonna L.; Radenbaugh, Amie J.; Zhang, Jianan Share Save
FGFR-Mediated Reactivation of MAPK Signaling Attenuates Antitumor Effects of Imatinib in Gastrointestinal Stromal Tumors Li, Fang; Huynh, Hung; Li, Xiaoyan; Ruddy, David A.; Wang, Youzhen; Ong, Richard; Chow, Pierce; Qiu, Shumei; Tam, Angela; Rakiec, Daniel P.; Schlegel, Robert; Monahan, John E.; Huang, Alan Share Save
Complete genomic landscape of a recurring sporadic parathyroid carcinoma Kasaian, Katayoon; Wiseman, Sam M.; Thiessen, Nina; Mungall, Karen L.; Corbett, Richard D.; Qian, Jenny Q.; Nip, Ka Ming; He, Ann; Tse, Kane; Chuah, Eric; Varhol, Richard J.; Pandoh, Pawan; McDonald, Helen; Zeng, Thomas; Tam, Angela; Schein, Jacquie; Birol, Inanc; Mungall, Andrew J.; Moore, Richard A.; Zhao, Yongjun; Hirst, Martin; Marra, Marco A.; Walker, Blair A.; Jones, Steven J. M. Share Save
Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver Hoffman, Brad G.; Robertson, Gordon; Zavaglia, Bogard; Beach, Mike; Cullum, Rebecca; Lee, Sam; Soukhatcheva, Galina; Li, Leping; Wederell, Elizabeth D.; Thiessen, Nina; Bilenky, Mikhail; Cezard, Timothee; Tam, Angela; Kamoh, Baljit; Birol, Inanc; Dai, Derek; Zhao, Yongjun; Hirst, Martin; Verchere, C. Bruce; Helgason, Cheryl D.; Marra, Marco A.; Jones, Steven J. M.; Hoodless, Pamela A. Share Save
A Genome-Wide Screen for Microdeletions Reveals Disruption of Polarity Complex Genes in Diverse Human Cancers Rothenberg, S. Michael; Mohapatra, Gayatry; Rivera, Miguel N.; Winokur, Daniel; Greninger, Patricia; Nitta, Mai; Sadow, Peter M.; Sooriyakumar, Gaya; Brannigan, Brian W.; Ulman, Matthew J.; Perera, Rushika M.; Wang, Rui; Tam, Angela; Ma, Xiao-Jun; Erlander, Mark; Sgroi, Dennis C.; Rocco, James W.; Lingen, Mark W.; Cohen, Ezra E. W.; Louis, David N.; Settleman, Jeffrey; Haber, Daniel A. Share Save
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin Morin, Ryan D.; Johnson, Nathalie A.; Severson, Tesa M.; Mungall, Andrew J.; An, Jianghong; Goya, Rodrigo; Paul, Jessica E.; Boyle, Merrill; Woolcock, Bruce W.; Kuchenbauer, Florian; Yap, Damian; Humphries, R. Keith; Griffith, Obi L.; Shah, Sohrab; Zhu, Henry; Kimbara, Michelle; Shashkin, Pavel; Charlot, Jean F.; Tcherpakov, Marianna; Corbett, Richard; Tam, Angela; Varhol, Richard; Smailus, Duane; Moksa, Michelle; Zhao, Yongjun; Delaney, Allen; Qian, Hong; Birol, Inanc; Schein, Jacqueline; Moore, Richard; Holt, Robert; Horsman, Doug E.; Connors, Joseph M.; Jones, Steven; Aparicio, Samuel; Hirst, Martin; Gascoyne, Randy D.; Marra, Marco A. Share Save
Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors McDermott, Ultan; Ames, Rachel Y.; Iafrate, A. John; Maheswaran, Shyamala; Stubbs, Hannah; Greninger, Patricia; McCutcheon, Kaitlin; Milano, Randy; Tam, Angela; Lee, Diana Y.; Lucien, Laury; Brannigan, Brian W.; Ulkus, Lindsey E.; Ma, Xiao-Jun; Erlander, Mark G.; Haber, Daniel A.; Sharma, Sreenath V.; Settleman, Jeffrey Share Save
Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells Wong, Lee H.; Ren, Hua; Williams, Evan; McGhie, James; Ahn, Soyeon; Sim, Marcus; Tam, Angela; Earle, Elizabeth; Anderson, Melissa A.; Mann, Jeffrey; Choo, K. H. Andy Share Save
Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding Robertson, A. Gordon; Bilenky, Mikhail; Tam, Angela; Zhao, Yongjun; Zeng, Thomas; Thiessen, Nina; Cezard, Timothee; Fejes, Anthony P.; Wederell, Elizabeth D.; Cullum, Rebecca; Euskirchen, Ghia; Krzywinski, Martin; Birol, Inanc; Snyder, Michael; Hoodless, Pamela A.; Hirst, Martin; Marra, Marco A.; Jones, Steven J. M. Share Save
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling McDermott, Ultan; Sharma, Sreenath V.; Dowell, Lori; Greninger, Patricia; Montagut, Clara; Lamb, Jennifer; Archibald, Heidi; Raudales, Raul; Tam, Angela; Lee, Diana; Rothenberg, S. Michael; Supko, Jeffrey G.; Sordella, Raffaella; Ulkus, Lindsey E.; Iafrate, A. John; Maheswaran, Shyamala; Njauw, Ching Ni; Tsao, Hensin; Drew, Lisa; Hanke, Jeff H.; Ma, Xiao-Jun; Erlander, Mark G.; Gray, Nathanael S.; Haber, Daniel A.; Settleman, Jeffrey Share Save
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